Abstract
Background - F2 isoprostanes are stable, free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Methods and Results - Specific assays were developed by use of mass spectrometry for the F2 isoprostanes iPF(2α)-III and iPF(2α)-VI and arachidonic acid (AA). Urinary excretion of the 2 F2 isoprostanes was significantly increased in hypercholesterolemic patients, whereas substrate AA in urine did not differ between the groups. iPF(2α)-III (pmol/mmol creatinine) was elevated (P2-III in LDL and urine were significantly correlated (r=0.42; P
| Original language | English |
|---|---|
| Pages (from-to) | 2822-2828 |
| Number of pages | 7 |
| Journal | Circulation |
| Volume | 98 |
| Issue number | 25 |
| Publication status | Published - Dec 22 1998 |
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Keywords
- Atherosclerosis
- Cholesterol
- Eicosanoids
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine
Cite this
Increased formation of distinct F2 isoprostanes in hypercholesterolemia. / Reilly, Muredach P.; Praticó, Domenico; Delanty, Norman; DiMinno, Giovanni; Tremoli, Elena; Rader, Daniel; Kapoor, Shiv; Rokach, Joshua; Lawson, John; FitzGerald, Garret A.
In: Circulation, Vol. 98, No. 25, 22.12.1998, p. 2822-2828.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased formation of distinct F2 isoprostanes in hypercholesterolemia
AU - Reilly, Muredach P.
AU - Praticó, Domenico
AU - Delanty, Norman
AU - DiMinno, Giovanni
AU - Tremoli, Elena
AU - Rader, Daniel
AU - Kapoor, Shiv
AU - Rokach, Joshua
AU - Lawson, John
AU - FitzGerald, Garret A.
PY - 1998/12/22
Y1 - 1998/12/22
N2 - Background - F2 isoprostanes are stable, free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Methods and Results - Specific assays were developed by use of mass spectrometry for the F2 isoprostanes iPF(2α)-III and iPF(2α)-VI and arachidonic acid (AA). Urinary excretion of the 2 F2 isoprostanes was significantly increased in hypercholesterolemic patients, whereas substrate AA in urine did not differ between the groups. iPF(2α)-III (pmol/mmol creatinine) was elevated (P2-III in LDL and urine were significantly correlated (r=0.42; P
AB - Background - F2 isoprostanes are stable, free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Methods and Results - Specific assays were developed by use of mass spectrometry for the F2 isoprostanes iPF(2α)-III and iPF(2α)-VI and arachidonic acid (AA). Urinary excretion of the 2 F2 isoprostanes was significantly increased in hypercholesterolemic patients, whereas substrate AA in urine did not differ between the groups. iPF(2α)-III (pmol/mmol creatinine) was elevated (P2-III in LDL and urine were significantly correlated (r=0.42; P
KW - Atherosclerosis
KW - Cholesterol
KW - Eicosanoids
UR - http://www.scopus.com/inward/record.url?scp=0032578979&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032578979&partnerID=8YFLogxK
M3 - Article
C2 - 9860782
AN - SCOPUS:0032578979
VL - 98
SP - 2822
EP - 2828
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 25
ER -