Abstract
Background - F2 isoprostanes are stable, free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Methods and Results - Specific assays were developed by use of mass spectrometry for the F2 isoprostanes iPF(2α)-III and iPF(2α)-VI and arachidonic acid (AA). Urinary excretion of the 2 F2 isoprostanes was significantly increased in hypercholesterolemic patients, whereas substrate AA in urine did not differ between the groups. iPF(2α)-III (pmol/mmol creatinine) was elevated (P2-III in LDL and urine were significantly correlated (r=0.42; P
Original language | English |
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Pages (from-to) | 2822-2828 |
Number of pages | 7 |
Journal | Circulation |
Volume | 98 |
Issue number | 25 |
Publication status | Published - Dec 22 1998 |
Keywords
- Atherosclerosis
- Cholesterol
- Eicosanoids
ASJC Scopus subject areas
- Physiology
- Cardiology and Cardiovascular Medicine