Increased formation of distinct F2 isoprostanes in hypercholesterolemia

Muredach P. Reilly; Domenico Praticó; Norman Delanty; Giovanni DiMinno; Elena Tremoli; Daniel Rader; Shiv Kapoor; Joshua Rokach; John Lawson; Garret A. FitzGerald

Increased formation of distinct F2 isoprostanes in hypercholesterolemia

Muredach P. Reilly, Domenico Praticó, Norman Delanty, Giovanni DiMinno, Elena Tremoli, Daniel Rader, Shiv Kapoor, Joshua Rokach, John Lawson, Garret A. FitzGerald

Centro Cardiologico Monzino

Research output: Contribution to journal › Article › peer-review

Abstract

Background - F₂ isoprostanes are stable, free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Methods and Results - Specific assays were developed by use of mass spectrometry for the F₂ isoprostanes iPF(2α)-III and iPF(2α)-VI and arachidonic acid (AA). Urinary excretion of the 2 F₂ isoprostanes was significantly increased in hypercholesterolemic patients, whereas substrate AA in urine did not differ between the groups. iPF(2α)-III (pmol/mmol creatinine) was elevated (P2-III in LDL and urine were significantly correlated (r=0.42; P

Original language	English
Pages (from-to)	2822-2828
Number of pages	7
Journal	Circulation
Volume	98
Issue number	25
Publication status	Published - Dec 22 1998

Keywords

Atherosclerosis
Cholesterol
Eicosanoids

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

Cite this

Increased formation of distinct F2 isoprostanes in hypercholesterolemia. / Reilly, Muredach P.; Praticó, Domenico; Delanty, Norman; DiMinno, Giovanni; Tremoli, Elena; Rader, Daniel; Kapoor, Shiv; Rokach, Joshua; Lawson, John; FitzGerald, Garret A.

In: Circulation, Vol. 98, No. 25, 22.12.1998, p. 2822-2828.

Research output: Contribution to journal › Article › peer-review

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abstract = "Background - F2 isoprostanes are stable, free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Methods and Results - Specific assays were developed by use of mass spectrometry for the F2 isoprostanes iPF(2α)-III and iPF(2α)-VI and arachidonic acid (AA). Urinary excretion of the 2 F2 isoprostanes was significantly increased in hypercholesterolemic patients, whereas substrate AA in urine did not differ between the groups. iPF(2α)-III (pmol/mmol creatinine) was elevated (P2-III in LDL and urine were significantly correlated (r=0.42; P",

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AU - Reilly, Muredach P.

AU - Praticó, Domenico

AU - Delanty, Norman

AU - DiMinno, Giovanni

AU - Tremoli, Elena

AU - Rader, Daniel

AU - Kapoor, Shiv

AU - Rokach, Joshua

AU - Lawson, John

AU - FitzGerald, Garret A.

PY - 1998/12/22

Y1 - 1998/12/22

N2 - Background - F2 isoprostanes are stable, free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Methods and Results - Specific assays were developed by use of mass spectrometry for the F2 isoprostanes iPF(2α)-III and iPF(2α)-VI and arachidonic acid (AA). Urinary excretion of the 2 F2 isoprostanes was significantly increased in hypercholesterolemic patients, whereas substrate AA in urine did not differ between the groups. iPF(2α)-III (pmol/mmol creatinine) was elevated (P2-III in LDL and urine were significantly correlated (r=0.42; P

AB - Background - F2 isoprostanes are stable, free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Methods and Results - Specific assays were developed by use of mass spectrometry for the F2 isoprostanes iPF(2α)-III and iPF(2α)-VI and arachidonic acid (AA). Urinary excretion of the 2 F2 isoprostanes was significantly increased in hypercholesterolemic patients, whereas substrate AA in urine did not differ between the groups. iPF(2α)-III (pmol/mmol creatinine) was elevated (P2-III in LDL and urine were significantly correlated (r=0.42; P

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KW - Cholesterol

KW - Eicosanoids

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Increased formation of distinct F2 isoprostanes in hypercholesterolemia

Abstract

Keywords

ASJC Scopus subject areas

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