Increased formation of distinct F2 isoprostanes in hypercholesterolemia

Muredach P. Reilly, Domenico Praticó, Norman Delanty, Giovanni DiMinno, Elena Tremoli, Daniel Rader, Shiv Kapoor, Joshua Rokach, John Lawson, Garret A. FitzGerald

Research output: Contribution to journalArticlepeer-review

Abstract

Background - F2 isoprostanes are stable, free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Methods and Results - Specific assays were developed by use of mass spectrometry for the F2 isoprostanes iPF(2α)-III and iPF(2α)-VI and arachidonic acid (AA). Urinary excretion of the 2 F2 isoprostanes was significantly increased in hypercholesterolemic patients, whereas substrate AA in urine did not differ between the groups. iPF(2α)-III (pmol/mmol creatinine) was elevated (P2-III in LDL and urine were significantly correlated (r=0.42; P

Original languageEnglish
Pages (from-to)2822-2828
Number of pages7
JournalCirculation
Volume98
Issue number25
Publication statusPublished - Dec 22 1998

Keywords

  • Atherosclerosis
  • Cholesterol
  • Eicosanoids

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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