Increased formation of distinct F2 isoprostanes in hypercholesterolemia

Muredach P. Reilly, Domenico Praticó, Norman Delanty, Giovanni DiMinno, Elena Tremoli, Daniel Rader, Shiv Kapoor, Joshua Rokach, John Lawson, Garret A. FitzGerald

Research output: Contribution to journalArticle

Abstract

Background - F2 isoprostanes are stable, free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Methods and Results - Specific assays were developed by use of mass spectrometry for the F2 isoprostanes iPF(2α)-III and iPF(2α)-VI and arachidonic acid (AA). Urinary excretion of the 2 F2 isoprostanes was significantly increased in hypercholesterolemic patients, whereas substrate AA in urine did not differ between the groups. iPF(2α)-III (pmol/mmol creatinine) was elevated (P2-III in LDL and urine were significantly correlated (r=0.42; P

Original languageEnglish
Pages (from-to)2822-2828
Number of pages7
JournalCirculation
Volume98
Issue number25
Publication statusPublished - Dec 22 1998

Fingerprint

F2-Isoprostanes
Hypercholesterolemia
Arachidonic Acid
Urine
Lipid Peroxidation
Free Radicals
Mass Spectrometry
Creatinine

Keywords

  • Atherosclerosis
  • Cholesterol
  • Eicosanoids

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Reilly, M. P., Praticó, D., Delanty, N., DiMinno, G., Tremoli, E., Rader, D., ... FitzGerald, G. A. (1998). Increased formation of distinct F2 isoprostanes in hypercholesterolemia. Circulation, 98(25), 2822-2828.

Increased formation of distinct F2 isoprostanes in hypercholesterolemia. / Reilly, Muredach P.; Praticó, Domenico; Delanty, Norman; DiMinno, Giovanni; Tremoli, Elena; Rader, Daniel; Kapoor, Shiv; Rokach, Joshua; Lawson, John; FitzGerald, Garret A.

In: Circulation, Vol. 98, No. 25, 22.12.1998, p. 2822-2828.

Research output: Contribution to journalArticle

Reilly, MP, Praticó, D, Delanty, N, DiMinno, G, Tremoli, E, Rader, D, Kapoor, S, Rokach, J, Lawson, J & FitzGerald, GA 1998, 'Increased formation of distinct F2 isoprostanes in hypercholesterolemia', Circulation, vol. 98, no. 25, pp. 2822-2828.
Reilly MP, Praticó D, Delanty N, DiMinno G, Tremoli E, Rader D et al. Increased formation of distinct F2 isoprostanes in hypercholesterolemia. Circulation. 1998 Dec 22;98(25):2822-2828.
Reilly, Muredach P. ; Praticó, Domenico ; Delanty, Norman ; DiMinno, Giovanni ; Tremoli, Elena ; Rader, Daniel ; Kapoor, Shiv ; Rokach, Joshua ; Lawson, John ; FitzGerald, Garret A. / Increased formation of distinct F2 isoprostanes in hypercholesterolemia. In: Circulation. 1998 ; Vol. 98, No. 25. pp. 2822-2828.
@article{1b6a502d382d410592fa0a50ea92b38c,
title = "Increased formation of distinct F2 isoprostanes in hypercholesterolemia",
abstract = "Background - F2 isoprostanes are stable, free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Methods and Results - Specific assays were developed by use of mass spectrometry for the F2 isoprostanes iPF(2α)-III and iPF(2α)-VI and arachidonic acid (AA). Urinary excretion of the 2 F2 isoprostanes was significantly increased in hypercholesterolemic patients, whereas substrate AA in urine did not differ between the groups. iPF(2α)-III (pmol/mmol creatinine) was elevated (P2-III in LDL and urine were significantly correlated (r=0.42; P",
keywords = "Atherosclerosis, Cholesterol, Eicosanoids",
author = "Reilly, {Muredach P.} and Domenico Pratic{\'o} and Norman Delanty and Giovanni DiMinno and Elena Tremoli and Daniel Rader and Shiv Kapoor and Joshua Rokach and John Lawson and FitzGerald, {Garret A.}",
year = "1998",
month = "12",
day = "22",
language = "English",
volume = "98",
pages = "2822--2828",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "25",

}

TY - JOUR

T1 - Increased formation of distinct F2 isoprostanes in hypercholesterolemia

AU - Reilly, Muredach P.

AU - Praticó, Domenico

AU - Delanty, Norman

AU - DiMinno, Giovanni

AU - Tremoli, Elena

AU - Rader, Daniel

AU - Kapoor, Shiv

AU - Rokach, Joshua

AU - Lawson, John

AU - FitzGerald, Garret A.

PY - 1998/12/22

Y1 - 1998/12/22

N2 - Background - F2 isoprostanes are stable, free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Methods and Results - Specific assays were developed by use of mass spectrometry for the F2 isoprostanes iPF(2α)-III and iPF(2α)-VI and arachidonic acid (AA). Urinary excretion of the 2 F2 isoprostanes was significantly increased in hypercholesterolemic patients, whereas substrate AA in urine did not differ between the groups. iPF(2α)-III (pmol/mmol creatinine) was elevated (P2-III in LDL and urine were significantly correlated (r=0.42; P

AB - Background - F2 isoprostanes are stable, free radical-catalyzed products of arachidonic acid that reflect lipid peroxidation in vivo. Methods and Results - Specific assays were developed by use of mass spectrometry for the F2 isoprostanes iPF(2α)-III and iPF(2α)-VI and arachidonic acid (AA). Urinary excretion of the 2 F2 isoprostanes was significantly increased in hypercholesterolemic patients, whereas substrate AA in urine did not differ between the groups. iPF(2α)-III (pmol/mmol creatinine) was elevated (P2-III in LDL and urine were significantly correlated (r=0.42; P

KW - Atherosclerosis

KW - Cholesterol

KW - Eicosanoids

UR - http://www.scopus.com/inward/record.url?scp=0032578979&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032578979&partnerID=8YFLogxK

M3 - Article

C2 - 9860782

AN - SCOPUS:0032578979

VL - 98

SP - 2822

EP - 2828

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 25

ER -