Increased frequency of complete hydatidiform mole in women with repeated abortion

Barbara Acaia, Fabio Parazzini, Carlo La Vecchia, Orietta Ricciardiello, Luigi Fedele, G. Battista Candiani

Research output: Contribution to journalArticle

Abstract

The association between spontaneous abortion and gestational trophoblastic disease (GTD) has been investigated in a study based on 93 women with 2 consecutive (repeated) spontaneous abortions and 82 control subjects who delivered normal babies. Nine molar pregnancies were observed among 7 of the 93 cases of repeated abortion while no control reported previous GTD. This difference was statistically significant and was not explained by allowance for age and number of pregnancies between cases and controls (x21 = 4.20; P = 0.04). When the observed number (9) of hydatidiform mole in the 385 pregnancies of the women with repeated abortion was compared with the expected one (0.28) based on the regional frequency data, the estimated relative risk was 32.1 with a 95% confidence interval from 13.9 to 63.3. The present findings confirm the association between GTD and spontaneous abortion and indicate that the risk is larger in women with repeated abortions.

Original languageEnglish
Pages (from-to)310-314
Number of pages5
JournalGynecologic Oncology
Volume31
Issue number2
DOIs
Publication statusPublished - 1988

Fingerprint

Gestational Trophoblastic Disease
Hydatidiform Mole
Spontaneous Abortion
Pregnancy
Confidence Intervals

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Oncology

Cite this

Acaia, B., Parazzini, F., La Vecchia, C., Ricciardiello, O., Fedele, L., & Battista Candiani, G. (1988). Increased frequency of complete hydatidiform mole in women with repeated abortion. Gynecologic Oncology, 31(2), 310-314. https://doi.org/10.1016/S0090-8258(88)80009-X

Increased frequency of complete hydatidiform mole in women with repeated abortion. / Acaia, Barbara; Parazzini, Fabio; La Vecchia, Carlo; Ricciardiello, Orietta; Fedele, Luigi; Battista Candiani, G.

In: Gynecologic Oncology, Vol. 31, No. 2, 1988, p. 310-314.

Research output: Contribution to journalArticle

Acaia, B, Parazzini, F, La Vecchia, C, Ricciardiello, O, Fedele, L & Battista Candiani, G 1988, 'Increased frequency of complete hydatidiform mole in women with repeated abortion', Gynecologic Oncology, vol. 31, no. 2, pp. 310-314. https://doi.org/10.1016/S0090-8258(88)80009-X
Acaia, Barbara ; Parazzini, Fabio ; La Vecchia, Carlo ; Ricciardiello, Orietta ; Fedele, Luigi ; Battista Candiani, G. / Increased frequency of complete hydatidiform mole in women with repeated abortion. In: Gynecologic Oncology. 1988 ; Vol. 31, No. 2. pp. 310-314.
@article{d72f75fe9dc3415787abe6a0105cfc9e,
title = "Increased frequency of complete hydatidiform mole in women with repeated abortion",
abstract = "The association between spontaneous abortion and gestational trophoblastic disease (GTD) has been investigated in a study based on 93 women with 2 consecutive (repeated) spontaneous abortions and 82 control subjects who delivered normal babies. Nine molar pregnancies were observed among 7 of the 93 cases of repeated abortion while no control reported previous GTD. This difference was statistically significant and was not explained by allowance for age and number of pregnancies between cases and controls (x21 = 4.20; P = 0.04). When the observed number (9) of hydatidiform mole in the 385 pregnancies of the women with repeated abortion was compared with the expected one (0.28) based on the regional frequency data, the estimated relative risk was 32.1 with a 95{\%} confidence interval from 13.9 to 63.3. The present findings confirm the association between GTD and spontaneous abortion and indicate that the risk is larger in women with repeated abortions.",
author = "Barbara Acaia and Fabio Parazzini and {La Vecchia}, Carlo and Orietta Ricciardiello and Luigi Fedele and {Battista Candiani}, G.",
year = "1988",
doi = "10.1016/S0090-8258(88)80009-X",
language = "English",
volume = "31",
pages = "310--314",
journal = "Gynecologic Oncology",
issn = "0090-8258",
publisher = "Academic Press Inc.",
number = "2",

}

TY - JOUR

T1 - Increased frequency of complete hydatidiform mole in women with repeated abortion

AU - Acaia, Barbara

AU - Parazzini, Fabio

AU - La Vecchia, Carlo

AU - Ricciardiello, Orietta

AU - Fedele, Luigi

AU - Battista Candiani, G.

PY - 1988

Y1 - 1988

N2 - The association between spontaneous abortion and gestational trophoblastic disease (GTD) has been investigated in a study based on 93 women with 2 consecutive (repeated) spontaneous abortions and 82 control subjects who delivered normal babies. Nine molar pregnancies were observed among 7 of the 93 cases of repeated abortion while no control reported previous GTD. This difference was statistically significant and was not explained by allowance for age and number of pregnancies between cases and controls (x21 = 4.20; P = 0.04). When the observed number (9) of hydatidiform mole in the 385 pregnancies of the women with repeated abortion was compared with the expected one (0.28) based on the regional frequency data, the estimated relative risk was 32.1 with a 95% confidence interval from 13.9 to 63.3. The present findings confirm the association between GTD and spontaneous abortion and indicate that the risk is larger in women with repeated abortions.

AB - The association between spontaneous abortion and gestational trophoblastic disease (GTD) has been investigated in a study based on 93 women with 2 consecutive (repeated) spontaneous abortions and 82 control subjects who delivered normal babies. Nine molar pregnancies were observed among 7 of the 93 cases of repeated abortion while no control reported previous GTD. This difference was statistically significant and was not explained by allowance for age and number of pregnancies between cases and controls (x21 = 4.20; P = 0.04). When the observed number (9) of hydatidiform mole in the 385 pregnancies of the women with repeated abortion was compared with the expected one (0.28) based on the regional frequency data, the estimated relative risk was 32.1 with a 95% confidence interval from 13.9 to 63.3. The present findings confirm the association between GTD and spontaneous abortion and indicate that the risk is larger in women with repeated abortions.

UR - http://www.scopus.com/inward/record.url?scp=0023765173&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023765173&partnerID=8YFLogxK

U2 - 10.1016/S0090-8258(88)80009-X

DO - 10.1016/S0090-8258(88)80009-X

M3 - Article

C2 - 3169620

AN - SCOPUS:0023765173

VL - 31

SP - 310

EP - 314

JO - Gynecologic Oncology

JF - Gynecologic Oncology

SN - 0090-8258

IS - 2

ER -