Increased fronto-temporal perfusion in bipolar disorder

N. Agarwal, M. Bellani, C. Perlini, G. Rambaldelli, M. Atzori, R. Cerini, F. Vecchiato, R. Pozzi Mucelli, Nicola Andreone, M. Balestrieri, M. Tansella, P. Brambilla

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Objectives: Previous imaging reports showed over-activation of fronto-limbic structures in bipolar patients, particularly in response to emotional stimuli. In this study, for the first time, we used perfusion weighted imaging (PWI) to analyze lobar cerebral blood volume (CBV) in bipolar disorder to further explore the vascular component to its pathophysiology. Methods: Fourteen patients with DSM-IV bipolar disorder (mean age ± SD = 49.00 ± 12.30 years; 6 males, 8 females) and 29 normal controls (mean age ± SD = 45.07 ± 10.30 years; 13 males, 16 females) were studied. PWI images were obtained following intravenous injection of paramagnetic contrast agent (Gadolinium-DTPA), with a 1.5 T Siemens magnet using an echo-planar sequence. The contrast of enhancement (CE), was calculated pixel by pixel as the ratio of the maximum signal intensity drop during the passage of contrast agent (Sm) by the baseline pre-bolus signal intensity (So) (CE = Sm/So*100) for frontal, temporal, parietal, and occipital lobes, bilaterally, on two axial images. Higher CE values correspond to lower CBV and viceversa. Results: Bipolar patients had significantly lower CE values in left frontal and temporal lobes (p = 0.01 and p = 0.03, respectively) and significantly inverse laterality index for frontal lobe (p = 0.017) compared to normal controls. No significant correlations between CE measure and age or clinical variables were found (p > 0.05). Conclusion: This study found increased left frontal and temporal CBV in bipolar disorder. Fronto-temporal hyper-perfusion may sustain over-activation of these structures during emotion modulation, which have been observed in patients with bipolar illness.

Original languageEnglish
Pages (from-to)106-114
Number of pages9
JournalJournal of Affective Disorders
Volume110
Issue number1-2
DOIs
Publication statusPublished - Sep 2008

Fingerprint

Bipolar Disorder
Frontal Lobe
Perfusion
Perfusion Imaging
Temporal Lobe
Contrast Media
Occipital Lobe
Gadolinium DTPA
Parietal Lobe
Magnets
Intravenous Injections
Diagnostic and Statistical Manual of Mental Disorders
Blood Vessels
Emotions
Cerebral Blood Volume

Keywords

  • Depression
  • Gadolinium
  • Neuroimaging
  • NMR
  • Perfusion
  • Vascular organization

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

Agarwal, N., Bellani, M., Perlini, C., Rambaldelli, G., Atzori, M., Cerini, R., ... Brambilla, P. (2008). Increased fronto-temporal perfusion in bipolar disorder. Journal of Affective Disorders, 110(1-2), 106-114. https://doi.org/10.1016/j.jad.2008.01.013

Increased fronto-temporal perfusion in bipolar disorder. / Agarwal, N.; Bellani, M.; Perlini, C.; Rambaldelli, G.; Atzori, M.; Cerini, R.; Vecchiato, F.; Pozzi Mucelli, R.; Andreone, Nicola; Balestrieri, M.; Tansella, M.; Brambilla, P.

In: Journal of Affective Disorders, Vol. 110, No. 1-2, 09.2008, p. 106-114.

Research output: Contribution to journalArticle

Agarwal, N, Bellani, M, Perlini, C, Rambaldelli, G, Atzori, M, Cerini, R, Vecchiato, F, Pozzi Mucelli, R, Andreone, N, Balestrieri, M, Tansella, M & Brambilla, P 2008, 'Increased fronto-temporal perfusion in bipolar disorder', Journal of Affective Disorders, vol. 110, no. 1-2, pp. 106-114. https://doi.org/10.1016/j.jad.2008.01.013
Agarwal N, Bellani M, Perlini C, Rambaldelli G, Atzori M, Cerini R et al. Increased fronto-temporal perfusion in bipolar disorder. Journal of Affective Disorders. 2008 Sep;110(1-2):106-114. https://doi.org/10.1016/j.jad.2008.01.013
Agarwal, N. ; Bellani, M. ; Perlini, C. ; Rambaldelli, G. ; Atzori, M. ; Cerini, R. ; Vecchiato, F. ; Pozzi Mucelli, R. ; Andreone, Nicola ; Balestrieri, M. ; Tansella, M. ; Brambilla, P. / Increased fronto-temporal perfusion in bipolar disorder. In: Journal of Affective Disorders. 2008 ; Vol. 110, No. 1-2. pp. 106-114.
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