Abstract
Objectives: Previous imaging reports showed over-activation of fronto-limbic structures in bipolar patients, particularly in response to emotional stimuli. In this study, for the first time, we used perfusion weighted imaging (PWI) to analyze lobar cerebral blood volume (CBV) in bipolar disorder to further explore the vascular component to its pathophysiology. Methods: Fourteen patients with DSM-IV bipolar disorder (mean age ± SD = 49.00 ± 12.30 years; 6 males, 8 females) and 29 normal controls (mean age ± SD = 45.07 ± 10.30 years; 13 males, 16 females) were studied. PWI images were obtained following intravenous injection of paramagnetic contrast agent (Gadolinium-DTPA), with a 1.5 T Siemens magnet using an echo-planar sequence. The contrast of enhancement (CE), was calculated pixel by pixel as the ratio of the maximum signal intensity drop during the passage of contrast agent (Sm) by the baseline pre-bolus signal intensity (So) (CE = Sm/So*100) for frontal, temporal, parietal, and occipital lobes, bilaterally, on two axial images. Higher CE values correspond to lower CBV and viceversa. Results: Bipolar patients had significantly lower CE values in left frontal and temporal lobes (p = 0.01 and p = 0.03, respectively) and significantly inverse laterality index for frontal lobe (p = 0.017) compared to normal controls. No significant correlations between CE measure and age or clinical variables were found (p > 0.05). Conclusion: This study found increased left frontal and temporal CBV in bipolar disorder. Fronto-temporal hyper-perfusion may sustain over-activation of these structures during emotion modulation, which have been observed in patients with bipolar illness.
| Original language | English |
|---|---|
| Pages (from-to) | 106-114 |
| Number of pages | 9 |
| Journal | Journal of Affective Disorders |
| Volume | 110 |
| Issue number | 1-2 |
| DOIs | |
| Publication status | Published - Sep 2008 |
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Keywords
- Depression
- Gadolinium
- Neuroimaging
- NMR
- Perfusion
- Vascular organization
ASJC Scopus subject areas
- Psychiatry and Mental health
- Behavioral Neuroscience
- Biological Psychiatry
- Neurology
- Psychology(all)
Cite this
Increased fronto-temporal perfusion in bipolar disorder. / Agarwal, N.; Bellani, M.; Perlini, C.; Rambaldelli, G.; Atzori, M.; Cerini, R.; Vecchiato, F.; Pozzi Mucelli, R.; Andreone, Nicola; Balestrieri, M.; Tansella, M.; Brambilla, P.
In: Journal of Affective Disorders, Vol. 110, No. 1-2, 09.2008, p. 106-114.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased fronto-temporal perfusion in bipolar disorder
AU - Agarwal, N.
AU - Bellani, M.
AU - Perlini, C.
AU - Rambaldelli, G.
AU - Atzori, M.
AU - Cerini, R.
AU - Vecchiato, F.
AU - Pozzi Mucelli, R.
AU - Andreone, Nicola
AU - Balestrieri, M.
AU - Tansella, M.
AU - Brambilla, P.
PY - 2008/9
Y1 - 2008/9
N2 - Objectives: Previous imaging reports showed over-activation of fronto-limbic structures in bipolar patients, particularly in response to emotional stimuli. In this study, for the first time, we used perfusion weighted imaging (PWI) to analyze lobar cerebral blood volume (CBV) in bipolar disorder to further explore the vascular component to its pathophysiology. Methods: Fourteen patients with DSM-IV bipolar disorder (mean age ± SD = 49.00 ± 12.30 years; 6 males, 8 females) and 29 normal controls (mean age ± SD = 45.07 ± 10.30 years; 13 males, 16 females) were studied. PWI images were obtained following intravenous injection of paramagnetic contrast agent (Gadolinium-DTPA), with a 1.5 T Siemens magnet using an echo-planar sequence. The contrast of enhancement (CE), was calculated pixel by pixel as the ratio of the maximum signal intensity drop during the passage of contrast agent (Sm) by the baseline pre-bolus signal intensity (So) (CE = Sm/So*100) for frontal, temporal, parietal, and occipital lobes, bilaterally, on two axial images. Higher CE values correspond to lower CBV and viceversa. Results: Bipolar patients had significantly lower CE values in left frontal and temporal lobes (p = 0.01 and p = 0.03, respectively) and significantly inverse laterality index for frontal lobe (p = 0.017) compared to normal controls. No significant correlations between CE measure and age or clinical variables were found (p > 0.05). Conclusion: This study found increased left frontal and temporal CBV in bipolar disorder. Fronto-temporal hyper-perfusion may sustain over-activation of these structures during emotion modulation, which have been observed in patients with bipolar illness.
AB - Objectives: Previous imaging reports showed over-activation of fronto-limbic structures in bipolar patients, particularly in response to emotional stimuli. In this study, for the first time, we used perfusion weighted imaging (PWI) to analyze lobar cerebral blood volume (CBV) in bipolar disorder to further explore the vascular component to its pathophysiology. Methods: Fourteen patients with DSM-IV bipolar disorder (mean age ± SD = 49.00 ± 12.30 years; 6 males, 8 females) and 29 normal controls (mean age ± SD = 45.07 ± 10.30 years; 13 males, 16 females) were studied. PWI images were obtained following intravenous injection of paramagnetic contrast agent (Gadolinium-DTPA), with a 1.5 T Siemens magnet using an echo-planar sequence. The contrast of enhancement (CE), was calculated pixel by pixel as the ratio of the maximum signal intensity drop during the passage of contrast agent (Sm) by the baseline pre-bolus signal intensity (So) (CE = Sm/So*100) for frontal, temporal, parietal, and occipital lobes, bilaterally, on two axial images. Higher CE values correspond to lower CBV and viceversa. Results: Bipolar patients had significantly lower CE values in left frontal and temporal lobes (p = 0.01 and p = 0.03, respectively) and significantly inverse laterality index for frontal lobe (p = 0.017) compared to normal controls. No significant correlations between CE measure and age or clinical variables were found (p > 0.05). Conclusion: This study found increased left frontal and temporal CBV in bipolar disorder. Fronto-temporal hyper-perfusion may sustain over-activation of these structures during emotion modulation, which have been observed in patients with bipolar illness.
KW - Depression
KW - Gadolinium
KW - Neuroimaging
KW - NMR
KW - Perfusion
KW - Vascular organization
UR - http://www.scopus.com/inward/record.url?scp=47849092034&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=47849092034&partnerID=8YFLogxK
U2 - 10.1016/j.jad.2008.01.013
DO - 10.1016/j.jad.2008.01.013
M3 - Article
C2 - 18291534
AN - SCOPUS:47849092034
VL - 110
SP - 106
EP - 114
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
SN - 0165-0327
IS - 1-2
ER -