Increased functional response to cocaine challenge following recovery from chronic corticosterone in the rat

Francesca R. Patacchioli, Francesco E. Pontieri, Renato Di Grezia, Vittorio Colangelo, Luciano Angelucci, Francesco Orzi

Research output: Contribution to journalArticlepeer-review

Abstract

Several lines of evidence suggest an interaction between glucocorticoids and the rat brain dopaminergic system. Here we demonstrate that a 14-day period of recovery from chronic corticosterone (10 mg/day for 21 consecutive days) potentiates the functional response to acute cocaine challenge in the rat by producing selective metabolic changes in limbic and motor areas, that are not measurable in vehicle-pretreated rats. These data indicate that chronic corticosterone has a long-term facilitatory role in the central effects of cocaine.

Original languageEnglish
Pages (from-to)159-162
Number of pages4
JournalEuropean Journal of Pharmacology
Volume336
Issue number2-3
DOIs
Publication statusPublished - Oct 8 1997

Keywords

  • Cocaine
  • Corticosterone
  • Deoxyglucose
  • Rat

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

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