Increased gray matter volume in lithium-treated bipolar disorder patients

Roberto B. Sassi, Mark Nicoletti, Paolo Brambilla, Alan G. Mallinger, Ellen Frank, David J. Kupfer, Matcheri S. Keshavan, Jair C. Soares

Research output: Contribution to journalArticlepeer-review


Lithium's neurotrophic effects have been reported in several in vitro and ex vivo studies. Preliminary human studies with magnetic resonance imaging (MRI) and spectroscopy have recently provided evidence of lithium-induced increases in gray matter volumes and N-acetyl-aspartate levels. In order to further examine the hypothesis that lithium treatment would relate to detectable increases in gray matter brain content, we blindly measured gray and white matter volumes in MRI images of 12 untreated and 17 lithium-treated bipolar patients and 46 healthy controls. Using multivariate analysis of covariance with age and gender as covariates, we found that total gray matter volumes were significantly increased in lithium-treated (747.9±69.8 cm3) compared with untreated patients (639.2±91.2 cm3; F=10.6; d.f.=1, 25; P=0.003) and healthy individuals (675.8±61.8 cm3; F=17.4; d.f.=1, 59; P

Original languageEnglish
Pages (from-to)243-245
Number of pages3
JournalNeuroscience Letters
Issue number2
Publication statusPublished - Aug 30 2002


  • Bipolar disorder
  • Gray matter
  • Lithium
  • Magnetic resonance imaging
  • Mood disorders
  • Neuroimaging

ASJC Scopus subject areas

  • Neuroscience(all)


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