Increased IL-6 and IL-4 in exhaled breath condensate of patients with nasal polyposis

Giovana Elisiana Carpaganano, P. Carratú, M. Gelardi, A. Spanevello, G. Di Gioia, T. Condreva, O. Resta, M. P Foschino Barbaro

Research output: Contribution to journalArticlepeer-review

Abstract

Background and Aim. Nasal polyposis (NP) occurs in about 14% of the worldwide population. Increased plasma concentrations of different pro-inflammatory cytokines have been observed in NP, and might be related to the pathogenesis of this syndrome. The present study was designed to investigate IL-6 and IL-4 concentrations in nasal and oral exhaled breath condensate of patients with early and advanced NP, and following polypectomy. Methods. Ten individuals with polyposis in early status, twenty-three patients affected by advanced status of NP and ten healthy controls were enrolled into the study. Exhaled breath condensate was collected by all individuals, according to a previous standardised method. An immunoassay kit was used to measure IL-6 and IL-4 levels. Results. Concentrations of oral and nasal exhaled IL-6 and IL-4 were significantly higher in patients with early nasal polyposis and advanced nasal polyposis, compared to healthy controls. A statistically significant decrease of nasally but not of orally exhaled IL-6 (p

Original languageEnglish
Pages (from-to)3-7
Number of pages5
JournalMonaldi Archives for Chest Disease - Cardiac Series
Volume71
Issue number1
Publication statusPublished - Mar 2009

Keywords

  • Exhaled breath condensate
  • IL-4
  • IL-6
  • Nasal polyposis
  • Polypectomy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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