Increased IL-8 levels in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis

Tiziana Mennini, L. Giordano, M. Mengozzi, P. Ghezzi, R. Tonelli, R. Mantegazza, V. Silani, M. Corbo, C. Lunetta, E. Beghi

Research output: Contribution to journalArticlepeer-review


Inflammation has been implicated in the pathogenesis of many neurodegenerative diseases. The chemokine IL-8 is thought to have a pathophysiological role in neurodegenerative diseases. IL-8 has recently been shown to induce death of primary cultured motor neurons in vitro. We determined IL-8 levels in the cerebrospinal fluid (CSF) from 38 patients with sporadic amyotrophic lateral sclerosis (ALS) compared to patients with other non-inflammatory neurological diseases (cerebrovascular disease, degenerative dementia, Parkinson's disease, compressive radiculo-myelopathy). Multiple sclerosis (MS) patients were used as positive controls. The levels of IL-8 in the CSF of ALS patients were significantly higher than those of patients with other, non-inflammatory neurological conditions and similar to those of MS patients. The only variable influencing IL-8 in ALS patients was sex, with higher levels in men than in women. The presence of the inflammatory cytokine IL-8 in the CSF of patients with ALS at the time of diagnosis strengthens the hypothesis of a role for this chemokine in neurodegenerative disorders.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalEuropean Journal of Inflammation
Issue number1
Publication statusPublished - Jan 2009


  • Amyotrophic lateral sclerosis
  • Cerebro spinal fluid
  • Chemokines
  • CXCR2
  • IL-8

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy


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