Increased IL-8 levels in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis

Tiziana Mennini, L. Giordano, M. Mengozzi, P. Ghezzi, R. Tonelli, R. Mantegazza, V. Silani, M. Corbo, C. Lunetta, E. Beghi

Research output: Contribution to journalArticle

Abstract

Inflammation has been implicated in the pathogenesis of many neurodegenerative diseases. The chemokine IL-8 is thought to have a pathophysiological role in neurodegenerative diseases. IL-8 has recently been shown to induce death of primary cultured motor neurons in vitro. We determined IL-8 levels in the cerebrospinal fluid (CSF) from 38 patients with sporadic amyotrophic lateral sclerosis (ALS) compared to patients with other non-inflammatory neurological diseases (cerebrovascular disease, degenerative dementia, Parkinson's disease, compressive radiculo-myelopathy). Multiple sclerosis (MS) patients were used as positive controls. The levels of IL-8 in the CSF of ALS patients were significantly higher than those of patients with other, non-inflammatory neurological conditions and similar to those of MS patients. The only variable influencing IL-8 in ALS patients was sex, with higher levels in men than in women. The presence of the inflammatory cytokine IL-8 in the CSF of patients with ALS at the time of diagnosis strengthens the hypothesis of a role for this chemokine in neurodegenerative disorders.

Original languageEnglish
Pages (from-to)39-44
Number of pages6
JournalEuropean Journal of Inflammation
Volume7
Issue number1
Publication statusPublished - Jan 2009

Fingerprint

Amyotrophic Lateral Sclerosis
Interleukin-8
Cerebrospinal Fluid
Neurodegenerative Diseases
Chemokines
Multiple Sclerosis
Cerebrovascular Disorders
Spinal Cord Compression
Motor Neurons
Parkinson Disease
Dementia
Cytokines
Inflammation

Keywords

  • Amyotrophic lateral sclerosis
  • Cerebro spinal fluid
  • Chemokines
  • CXCR2
  • IL-8

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Increased IL-8 levels in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis. / Mennini, Tiziana; Giordano, L.; Mengozzi, M.; Ghezzi, P.; Tonelli, R.; Mantegazza, R.; Silani, V.; Corbo, M.; Lunetta, C.; Beghi, E.

In: European Journal of Inflammation, Vol. 7, No. 1, 01.2009, p. 39-44.

Research output: Contribution to journalArticle

Mennini, Tiziana ; Giordano, L. ; Mengozzi, M. ; Ghezzi, P. ; Tonelli, R. ; Mantegazza, R. ; Silani, V. ; Corbo, M. ; Lunetta, C. ; Beghi, E. / Increased IL-8 levels in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis. In: European Journal of Inflammation. 2009 ; Vol. 7, No. 1. pp. 39-44.
@article{0bce6fe970b240e8b24e2444295ce044,
title = "Increased IL-8 levels in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis",
abstract = "Inflammation has been implicated in the pathogenesis of many neurodegenerative diseases. The chemokine IL-8 is thought to have a pathophysiological role in neurodegenerative diseases. IL-8 has recently been shown to induce death of primary cultured motor neurons in vitro. We determined IL-8 levels in the cerebrospinal fluid (CSF) from 38 patients with sporadic amyotrophic lateral sclerosis (ALS) compared to patients with other non-inflammatory neurological diseases (cerebrovascular disease, degenerative dementia, Parkinson's disease, compressive radiculo-myelopathy). Multiple sclerosis (MS) patients were used as positive controls. The levels of IL-8 in the CSF of ALS patients were significantly higher than those of patients with other, non-inflammatory neurological conditions and similar to those of MS patients. The only variable influencing IL-8 in ALS patients was sex, with higher levels in men than in women. The presence of the inflammatory cytokine IL-8 in the CSF of patients with ALS at the time of diagnosis strengthens the hypothesis of a role for this chemokine in neurodegenerative disorders.",
keywords = "Amyotrophic lateral sclerosis, Cerebro spinal fluid, Chemokines, CXCR2, IL-8",
author = "Tiziana Mennini and L. Giordano and M. Mengozzi and P. Ghezzi and R. Tonelli and R. Mantegazza and V. Silani and M. Corbo and C. Lunetta and E. Beghi",
year = "2009",
month = "1",
language = "English",
volume = "7",
pages = "39--44",
journal = "European Journal of Inflammation",
issn = "1721-727X",
publisher = "Biolife",
number = "1",

}

TY - JOUR

T1 - Increased IL-8 levels in the cerebrospinal fluid of patients with amyotrophic lateral sclerosis

AU - Mennini, Tiziana

AU - Giordano, L.

AU - Mengozzi, M.

AU - Ghezzi, P.

AU - Tonelli, R.

AU - Mantegazza, R.

AU - Silani, V.

AU - Corbo, M.

AU - Lunetta, C.

AU - Beghi, E.

PY - 2009/1

Y1 - 2009/1

N2 - Inflammation has been implicated in the pathogenesis of many neurodegenerative diseases. The chemokine IL-8 is thought to have a pathophysiological role in neurodegenerative diseases. IL-8 has recently been shown to induce death of primary cultured motor neurons in vitro. We determined IL-8 levels in the cerebrospinal fluid (CSF) from 38 patients with sporadic amyotrophic lateral sclerosis (ALS) compared to patients with other non-inflammatory neurological diseases (cerebrovascular disease, degenerative dementia, Parkinson's disease, compressive radiculo-myelopathy). Multiple sclerosis (MS) patients were used as positive controls. The levels of IL-8 in the CSF of ALS patients were significantly higher than those of patients with other, non-inflammatory neurological conditions and similar to those of MS patients. The only variable influencing IL-8 in ALS patients was sex, with higher levels in men than in women. The presence of the inflammatory cytokine IL-8 in the CSF of patients with ALS at the time of diagnosis strengthens the hypothesis of a role for this chemokine in neurodegenerative disorders.

AB - Inflammation has been implicated in the pathogenesis of many neurodegenerative diseases. The chemokine IL-8 is thought to have a pathophysiological role in neurodegenerative diseases. IL-8 has recently been shown to induce death of primary cultured motor neurons in vitro. We determined IL-8 levels in the cerebrospinal fluid (CSF) from 38 patients with sporadic amyotrophic lateral sclerosis (ALS) compared to patients with other non-inflammatory neurological diseases (cerebrovascular disease, degenerative dementia, Parkinson's disease, compressive radiculo-myelopathy). Multiple sclerosis (MS) patients were used as positive controls. The levels of IL-8 in the CSF of ALS patients were significantly higher than those of patients with other, non-inflammatory neurological conditions and similar to those of MS patients. The only variable influencing IL-8 in ALS patients was sex, with higher levels in men than in women. The presence of the inflammatory cytokine IL-8 in the CSF of patients with ALS at the time of diagnosis strengthens the hypothesis of a role for this chemokine in neurodegenerative disorders.

KW - Amyotrophic lateral sclerosis

KW - Cerebro spinal fluid

KW - Chemokines

KW - CXCR2

KW - IL-8

UR - http://www.scopus.com/inward/record.url?scp=65549167449&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=65549167449&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:65549167449

VL - 7

SP - 39

EP - 44

JO - European Journal of Inflammation

JF - European Journal of Inflammation

SN - 1721-727X

IS - 1

ER -