Increased incidence of axonal Guillain-Barré syndrome in La Spezia area of Italy

A 13-year follow-up study

Luana Benedetti, Chiara Briani, Alessandro Beronio, Federico Massa, Elisa Giorli, Cinzia Sani, Paola Delia, Stefania Artioli, Maria P. Sormani, Antonio Mannironi, Antonio Tartaglione, Giovanni L. Mancardi

Research output: Contribution to journalArticle

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Abstract

Guillain-Barré syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy with a worldwide incidence of 0.81-1.89 per 100 000 person-years. In Europe and North America only 5% of patients with GBS have axonal subtypes, which in South America and Asia account for 30%-47% of cases. The aim of our study is to assess the annual incidence and clinical features of GBS in La Spezia area in Italy. A retrospective (from 1 January 2003 to 31 December 2011) followed by a prospective (from 1 January 2012 to 31 December 2015) analysis was carried out on patients admitted to La Spezia hospital who fulfilled the GBS diagnostic criteria. A total of 86 patients (58 men), mean age of 62.7 years (range 21-90), were included. The mean annual incidence rate was 3/100 000 (range: 0.9/100 000-5.37/100 000) significantly higher than the European incidence (P < 0.001). Forty-seven percent were classified as acute inflammatory demyelinating polyradiculoneuropathy (AIDP), 35% as acute motor and motor-sensory axonal neuropathy (AMAN-AMSAN), 13% as variant forms, and 5% were not defined. AIDP was most common in “Golfo dei Poeti” (50%) and “Val di Magra” (63.2%), whereas AMAN/AMSAN prevailed in “Val di Vara” (63.6%) and “Riviera Spezzina” (62.5%) (P = 0.024). In La Spezia area GBS incidence (especially the AMAN subtype) is significantly higher than the incidence reported in Europe. AIDP predominates in the eastern area whereas AMAN/AMSAN in the western, with a significantly different incidence rate (P = 0.003). Prospective studies to assess possible predisposing environmental factors are needed.

Original languageEnglish
JournalJournal of the Peripheral Nervous System
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Italy
Incidence
Guillain-Barre Syndrome
Polyradiculoneuropathy
South America
North America
Causality
Prospective Studies

Keywords

  • AIDP
  • AMAN
  • annual incidence
  • Guillain-Barré syndrome

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Increased incidence of axonal Guillain-Barré syndrome in La Spezia area of Italy : A 13-year follow-up study. / Benedetti, Luana; Briani, Chiara; Beronio, Alessandro; Massa, Federico; Giorli, Elisa; Sani, Cinzia; Delia, Paola; Artioli, Stefania; Sormani, Maria P.; Mannironi, Antonio; Tartaglione, Antonio; Mancardi, Giovanni L.

In: Journal of the Peripheral Nervous System, 01.01.2018.

Research output: Contribution to journalArticle

Benedetti, Luana ; Briani, Chiara ; Beronio, Alessandro ; Massa, Federico ; Giorli, Elisa ; Sani, Cinzia ; Delia, Paola ; Artioli, Stefania ; Sormani, Maria P. ; Mannironi, Antonio ; Tartaglione, Antonio ; Mancardi, Giovanni L. / Increased incidence of axonal Guillain-Barré syndrome in La Spezia area of Italy : A 13-year follow-up study. In: Journal of the Peripheral Nervous System. 2018.
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abstract = "Guillain-Barr{\'e} syndrome (GBS) is an acute immune-mediated polyradiculoneuropathy with a worldwide incidence of 0.81-1.89 per 100 000 person-years. In Europe and North America only 5{\%} of patients with GBS have axonal subtypes, which in South America and Asia account for 30{\%}-47{\%} of cases. The aim of our study is to assess the annual incidence and clinical features of GBS in La Spezia area in Italy. A retrospective (from 1 January 2003 to 31 December 2011) followed by a prospective (from 1 January 2012 to 31 December 2015) analysis was carried out on patients admitted to La Spezia hospital who fulfilled the GBS diagnostic criteria. A total of 86 patients (58 men), mean age of 62.7 years (range 21-90), were included. The mean annual incidence rate was 3/100 000 (range: 0.9/100 000-5.37/100 000) significantly higher than the European incidence (P < 0.001). Forty-seven percent were classified as acute inflammatory demyelinating polyradiculoneuropathy (AIDP), 35{\%} as acute motor and motor-sensory axonal neuropathy (AMAN-AMSAN), 13{\%} as variant forms, and 5{\%} were not defined. AIDP was most common in “Golfo dei Poeti” (50{\%}) and “Val di Magra” (63.2{\%}), whereas AMAN/AMSAN prevailed in “Val di Vara” (63.6{\%}) and “Riviera Spezzina” (62.5{\%}) (P = 0.024). In La Spezia area GBS incidence (especially the AMAN subtype) is significantly higher than the incidence reported in Europe. AIDP predominates in the eastern area whereas AMAN/AMSAN in the western, with a significantly different incidence rate (P = 0.003). Prospective studies to assess possible predisposing environmental factors are needed.",
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AU - Beronio, Alessandro

AU - Massa, Federico

AU - Giorli, Elisa

AU - Sani, Cinzia

AU - Delia, Paola

AU - Artioli, Stefania

AU - Sormani, Maria P.

AU - Mannironi, Antonio

AU - Tartaglione, Antonio

AU - Mancardi, Giovanni L.

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