Increased incidence of FMO1 gene single nucleotide polymorphisms in sporadic amyotrophic lateral sclerosis

Cristina Cereda, Elisa Gabanti, Manuel Corato, Annalisa De Silvestri, Dario Alimonti, Emanuela Cova, Andrea Malaspina, Mauro Ceroni

Research output: Contribution to journalArticlepeer-review

Abstract

Flavin-containing monooxygenases (FMO) represent a gene family involved in the oxidative metabolism of a variety of xenobiotics, pesticides and drugs. A new function for FMO proteins has been recently uncovered: yeast FMO has been demonstrated to take part in maintaining the redox balance, catalysing the oxidation of reduced glutathione (GSH) to glutathione disulfide (GSSG). The GSSG/GSH balance is an important buffering system for reactive oxygen species and its involvement has been documented in ALS and other neurodegenerative disorders. Human FMO genes present different mutations, which may be related to ethnicity, altered metabolic activity and, in some cases, specific diseases. The human FMO1 gene presents 20 single nucleotide polymorphisms (SNPs) located in coding regions, intronic sequences and untranslated regions. The FMO1 gene has also recently been found underexpressed in spinal cord of ALS patients. Using SSCP and direct sequencing, we studied the allelic and genotypic frequency of two 3′UTR SNPs of the FMO1 gene in sporadic ALS patients compared to a healthy control population. We found a significantly higher frequency of these two polymorphisms, exclusive of the female population, in SALS patients compared to controls (p

Original languageEnglish
Pages (from-to)233-240
Number of pages8
JournalAmyotrophic Lateral Sclerosis
Volume7
Issue number4
DOIs
Publication statusPublished - Dec 1 2006

Keywords

  • Flavin-containing monooxygenases (FMO)
  • Single-nucleotide polymorphisms (SNPs)
  • Sporadic amyotrophic lateral sclerosis (sporadic ALS)

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Fingerprint Dive into the research topics of 'Increased incidence of FMO1 gene single nucleotide polymorphisms in sporadic amyotrophic lateral sclerosis'. Together they form a unique fingerprint.

Cite this