Abstract
Introduction: Cancer heterogeneity and degree of intra-tumoral immune cells represent variables affecting overall survival (OS). The present study investigated the impact of natural killer (NK) and T cells infiltrating colorectal liver metastases (CLM) in patients undergoing hepatectomy after neoadjuvant chemotherapy. Methods: The frequencies of intra-tumoral, marginal, and peritumoral CD3+ T and NKp46+ NK cells were determined for 121 patients. OS was assessed in relation to prognostic factors. Results: At univariate analysis, several variables, including T and N of the primary tumor, metachronous CLM, radiological response, and higher density of intra-tumoral CD3+ T cell (>1%/mm2) and of NKp46+ NK cells (>1 cell/mm2), were associated with OS. Only increased frequencies of intra-tumoral CD3+ T cells (p = 0.005) and NKp46+ NK cells (p = 0.004) correlated with OS at multivariate analysis. The logistic regression revealed that metachronous CLM (OR = 2.781; p = 0.002), the use of an epidermal growth factor receptor inhibitor (OR = 3.891; p = 0.001), and radiological response (OR = 3.219; p = 0.001) were associated with higher infiltration of these cells. Conclusions: High frequencies of NK and T cells in response to chemotherapy predict OS in CLM patients. These findings provide important insights that can help physicians to choose the best treatment option and adopt more predictive follow-up strategies for patients with CLM.
| Original language | English |
|---|---|
| Pages (from-to) | 1226-1236 |
| Number of pages | 11 |
| Journal | Journal of Gastrointestinal Surgery |
| Volume | 21 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 1 2017 |
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Keywords
- Chemotherapy
- Colorectal liver metastases
- Immune response to colorectal liver metastases
- Natural killer cells
- T cells
ASJC Scopus subject areas
- Surgery
- Gastroenterology
Cite this
Increased Infiltration of Natural Killer and T Cells in Colorectal Liver Metastases Improves Patient Overall Survival. / Donadon, Matteo; Hudspeth, Kelly; Cimino, Matteo; Di Tommaso, Luca; Preti, Max; Tentorio, Paolo; Roncalli, Massimo; Mavilio, Domenico; Torzilli, Guido.
In: Journal of Gastrointestinal Surgery, Vol. 21, No. 8, 01.08.2017, p. 1226-1236.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased Infiltration of Natural Killer and T Cells in Colorectal Liver Metastases Improves Patient Overall Survival
AU - Donadon, Matteo
AU - Hudspeth, Kelly
AU - Cimino, Matteo
AU - Di Tommaso, Luca
AU - Preti, Max
AU - Tentorio, Paolo
AU - Roncalli, Massimo
AU - Mavilio, Domenico
AU - Torzilli, Guido
PY - 2017/8/1
Y1 - 2017/8/1
N2 - Introduction: Cancer heterogeneity and degree of intra-tumoral immune cells represent variables affecting overall survival (OS). The present study investigated the impact of natural killer (NK) and T cells infiltrating colorectal liver metastases (CLM) in patients undergoing hepatectomy after neoadjuvant chemotherapy. Methods: The frequencies of intra-tumoral, marginal, and peritumoral CD3+ T and NKp46+ NK cells were determined for 121 patients. OS was assessed in relation to prognostic factors. Results: At univariate analysis, several variables, including T and N of the primary tumor, metachronous CLM, radiological response, and higher density of intra-tumoral CD3+ T cell (>1%/mm2) and of NKp46+ NK cells (>1 cell/mm2), were associated with OS. Only increased frequencies of intra-tumoral CD3+ T cells (p = 0.005) and NKp46+ NK cells (p = 0.004) correlated with OS at multivariate analysis. The logistic regression revealed that metachronous CLM (OR = 2.781; p = 0.002), the use of an epidermal growth factor receptor inhibitor (OR = 3.891; p = 0.001), and radiological response (OR = 3.219; p = 0.001) were associated with higher infiltration of these cells. Conclusions: High frequencies of NK and T cells in response to chemotherapy predict OS in CLM patients. These findings provide important insights that can help physicians to choose the best treatment option and adopt more predictive follow-up strategies for patients with CLM.
AB - Introduction: Cancer heterogeneity and degree of intra-tumoral immune cells represent variables affecting overall survival (OS). The present study investigated the impact of natural killer (NK) and T cells infiltrating colorectal liver metastases (CLM) in patients undergoing hepatectomy after neoadjuvant chemotherapy. Methods: The frequencies of intra-tumoral, marginal, and peritumoral CD3+ T and NKp46+ NK cells were determined for 121 patients. OS was assessed in relation to prognostic factors. Results: At univariate analysis, several variables, including T and N of the primary tumor, metachronous CLM, radiological response, and higher density of intra-tumoral CD3+ T cell (>1%/mm2) and of NKp46+ NK cells (>1 cell/mm2), were associated with OS. Only increased frequencies of intra-tumoral CD3+ T cells (p = 0.005) and NKp46+ NK cells (p = 0.004) correlated with OS at multivariate analysis. The logistic regression revealed that metachronous CLM (OR = 2.781; p = 0.002), the use of an epidermal growth factor receptor inhibitor (OR = 3.891; p = 0.001), and radiological response (OR = 3.219; p = 0.001) were associated with higher infiltration of these cells. Conclusions: High frequencies of NK and T cells in response to chemotherapy predict OS in CLM patients. These findings provide important insights that can help physicians to choose the best treatment option and adopt more predictive follow-up strategies for patients with CLM.
KW - Chemotherapy
KW - Colorectal liver metastases
KW - Immune response to colorectal liver metastases
KW - Natural killer cells
KW - T cells
UR - http://www.scopus.com/inward/record.url?scp=85019897668&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019897668&partnerID=8YFLogxK
U2 - 10.1007/s11605-017-3446-6
DO - 10.1007/s11605-017-3446-6
M3 - Article
AN - SCOPUS:85019897668
VL - 21
SP - 1226
EP - 1236
JO - Journal of Gastrointestinal Surgery
JF - Journal of Gastrointestinal Surgery
SN - 1091-255X
IS - 8
ER -