Increased interictal cerebral glucose metabolism in a cortical-subcortical network in drug naive patients with crytogenic temporal lobe epilepsy

Massimo Franceschi, Giovanni Lucignani, Angelo Del Sole, Chiara Grana, Sergio Bressi, Fabio Minicucci, Cristina Messa, Maria Paola Canevini, Ferruccio Fazio

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Positron emission tomography with [18F]- 2-fluoro-2-deoxy-D- glucose ([18F]FDG) has been used to assess the pattern of cerebral metabolism in different types of epilepsies. However, PET with [ 18F]FDG has never been used to evaluate drug naive patients with cryptogenic temporal lobe epilepsy, in whom the mechanism of origin and diffusion of the epileptic discharge may differ from that underlying other epilepsies. In a group of patients with cryptogenic temporal lobe epilepsy, never treated with antiepileptic drugs, evidence has been found of significant interictal glucose hypermetabolism in a bilateral neural network including the temporal lobes, thalami, basal ganglia, and cingular cortices. The metabolism in these areas and frontal lateral cortex enables the correct classification of all patients with temporal lobe epilepsy and controls by discriminant function analysis. Other cortical areas-namely, frontal basal and lateral, temporal mesial, and cerebellar cortices-had bilateral increases of glucose metabolism ranging from 10 to 15% of normal controls, although lacking stringent statistical significance. This metabolic pattern could represent a pathophysiological state of hyperactivity predisposing to epileptic discharge generation or diffusion, or else a network of inhibitory circuits activated to prevent the diffusion of the epileptic discharge.

Original languageEnglish
Pages (from-to)427-431
Number of pages5
JournalJournal of Neurology, Neurosurgery and Psychiatry
Volume59
Issue number4
DOIs
Publication statusPublished - 1995

Fingerprint

Temporal Lobe Epilepsy
Fluorodeoxyglucose F18
Temporal Lobe
Glucose
Epilepsy
Pharmaceutical Preparations
Cerebellar Cortex
Frontal Lobe
Discriminant Analysis
Basal Ganglia
Thalamus
Positron-Emission Tomography
Anticonvulsants

Keywords

  • Cryptogenic temporal lobe epilepsy
  • Epilepsy
  • Refractory epilepsy

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Psychiatry and Mental health
  • Neuroscience(all)
  • Neuropsychology and Physiological Psychology

Cite this

Increased interictal cerebral glucose metabolism in a cortical-subcortical network in drug naive patients with crytogenic temporal lobe epilepsy. / Franceschi, Massimo; Lucignani, Giovanni; Del Sole, Angelo; Grana, Chiara; Bressi, Sergio; Minicucci, Fabio; Messa, Cristina; Canevini, Maria Paola; Fazio, Ferruccio.

In: Journal of Neurology, Neurosurgery and Psychiatry, Vol. 59, No. 4, 1995, p. 427-431.

Research output: Contribution to journalArticle

Franceschi, Massimo ; Lucignani, Giovanni ; Del Sole, Angelo ; Grana, Chiara ; Bressi, Sergio ; Minicucci, Fabio ; Messa, Cristina ; Canevini, Maria Paola ; Fazio, Ferruccio. / Increased interictal cerebral glucose metabolism in a cortical-subcortical network in drug naive patients with crytogenic temporal lobe epilepsy. In: Journal of Neurology, Neurosurgery and Psychiatry. 1995 ; Vol. 59, No. 4. pp. 427-431.
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