Increased interleukin-10 serum levels in patients with solid tumours

Claudio Fortis, Marco Foppoli, Luca Gianotti, Laura Galli, Giovanni Citterio, Giuseppe Consogno, Oreste Gentilini, Marco Braga

Research output: Contribution to journalArticle

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Abstract

In 40 out of 99 patients (40.4%) with solid tumours of different tissue, but the same stage (IV), elevated serum levels of interleukin-10 were observed. The mean levels of the cytokine in patients with malignant melanoma (24.3 ng/ml), pancreatic (6.8 ng/ml) or gastric (6.3 ng/ml) adenocarcinoma were significantly higher than in healthy subjects (3.4 ng/ml) or in patients with uterine fibroma (1.7 ng/ml). Patients with colon (6.8 ng/ml) and renal (5.7 ng/ml) carcinoma had similar values of interleukin-10 but did not significantly differ from controls. Interleukin-10 is known to suppress the functions of both T lymphocytes and macrophages, working as a general dampener of the immune and inflammatory responses. The observation of increased circulating levels of interleukin-10 in cancer patients may have important implications for future investigations, immunological monitoring and therapeutic intervention on neoplastic patients, and suggests a mechanism for tumour cells escaping from immune surveillance.

Original languageEnglish
Pages (from-to)1-5
Number of pages5
JournalCancer Letters
Volume104
Issue number1
DOIs
Publication statusPublished - Jun 24 1996

Fingerprint

Interleukin-10
Serum
Neoplasms
Immunologic Monitoring
Leiomyoma
Melanoma
Stomach
Healthy Volunteers
Colon
Adenocarcinoma
Macrophages
Observation
Cytokines
Carcinoma
T-Lymphocytes
Kidney

Keywords

  • Immune surveillance
  • Immunological escape
  • Interleukin-10
  • Macrophages
  • Solid tumour
  • T lymphocytes

ASJC Scopus subject areas

  • Cancer Research
  • Molecular Biology
  • Oncology

Cite this

Increased interleukin-10 serum levels in patients with solid tumours. / Fortis, Claudio; Foppoli, Marco; Gianotti, Luca; Galli, Laura; Citterio, Giovanni; Consogno, Giuseppe; Gentilini, Oreste; Braga, Marco.

In: Cancer Letters, Vol. 104, No. 1, 24.06.1996, p. 1-5.

Research output: Contribution to journalArticle

Fortis C, Foppoli M, Gianotti L, Galli L, Citterio G, Consogno G et al. Increased interleukin-10 serum levels in patients with solid tumours. Cancer Letters. 1996 Jun 24;104(1):1-5. https://doi.org/10.1016/0304-3835(96)04213-9
Fortis, Claudio ; Foppoli, Marco ; Gianotti, Luca ; Galli, Laura ; Citterio, Giovanni ; Consogno, Giuseppe ; Gentilini, Oreste ; Braga, Marco. / Increased interleukin-10 serum levels in patients with solid tumours. In: Cancer Letters. 1996 ; Vol. 104, No. 1. pp. 1-5.
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AU - Gentilini, Oreste

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AB - In 40 out of 99 patients (40.4%) with solid tumours of different tissue, but the same stage (IV), elevated serum levels of interleukin-10 were observed. The mean levels of the cytokine in patients with malignant melanoma (24.3 ng/ml), pancreatic (6.8 ng/ml) or gastric (6.3 ng/ml) adenocarcinoma were significantly higher than in healthy subjects (3.4 ng/ml) or in patients with uterine fibroma (1.7 ng/ml). Patients with colon (6.8 ng/ml) and renal (5.7 ng/ml) carcinoma had similar values of interleukin-10 but did not significantly differ from controls. Interleukin-10 is known to suppress the functions of both T lymphocytes and macrophages, working as a general dampener of the immune and inflammatory responses. The observation of increased circulating levels of interleukin-10 in cancer patients may have important implications for future investigations, immunological monitoring and therapeutic intervention on neoplastic patients, and suggests a mechanism for tumour cells escaping from immune surveillance.

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