Increased jejunal intraepithelial lymphocytes bearing γ δ T-cell receptor in dermatitis herpetiformis

Maurizio Vecchi, Lucia Crosti, Emilio Berti, Daniela Agape, Amilcare Cerri, Roberto De Franchis

Research output: Contribution to journalArticlepeer-review

Abstract

T-cell receptor 1 ( γ δ) expression was studied in 19 jejunal or duodenal specimens from patients with dermatitis herpetiformis and in 16 jejunal or duodenal specimens showing normal histology. In normal specimens, γ δ + cells represented 10.8% of intraepithelial CD3+ lymphocytes. Around 50% of these cells were recognized by the A13 monoclonal antibody, which detects products of the Vγ1 Vδ1 gene rearrangement and the non-disulfide-linked form of T-cell receptor 1. The remaining 50% reacted with the BB3 monoclonal antibody, which recognizes products of the Vγ9 Vδ2 rearrangement and the disulfide-linked form of receptor. Very few γ δ + cells were observed in the lamina propria. In jejunal specimens from patients with dermatitis herpetiformis, a significant increase in the prevance of γ δ + intraepithelial lymphocytes was observed (P <0.001). This finding was largely accounted for by an increase in those cells recognized by the A13 monoclonal antibody, thus possibly expressing the Vγ1 Vδ1 rearrangement and the nondisulfide-linked form of receptor. These data suggest that similar pathogenetic mechanisms may be active in determining the jejunal damage in celiac disease and dermatitis herpetiformis.

Original languageEnglish
Pages (from-to)1499-1505
Number of pages7
JournalGastroenterology
Volume102
Issue number5
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Gastroenterology

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