Increased level of thyroglobulin mRNA in a human familial goiter

A. Monticelli, V. E. Avvedimento, A. Mariano, C. Marcocci, L. Chiovato, G. F. Fenzi, A. Pinchera, S. Varrone

Research output: Contribution to journalArticle

Abstract

Thyroglobulin (Tg) and its specific mRNA were analyzed in the thyroid gland of two cases of familial goiter. A three-fold increase in the level of stable protein and functional Tg mRNA was found in the goiter of one of the two patients in whom a desiodase defect was demonstrated. Normal concentrations of both Tg and its mRNA were found in the other goiter in which no enzymatic defect could be shown. Our results suggest that the increase of Tg mRNA levels found in the goiter with a desiodase defect was due to a chronic stimulation of the gland by TSH.

Original languageEnglish
Pages (from-to)59-63
Number of pages5
JournalJournal of Endocrinological Investigation
Volume10
Issue number1
DOIs
Publication statusPublished - 1987

Fingerprint

Thyroglobulin
Goiter
Messenger RNA
Thyroid Gland
Proteins

Keywords

  • desiodase defect
  • goiter
  • mRNA
  • Thyroglobulin

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Monticelli, A., Avvedimento, V. E., Mariano, A., Marcocci, C., Chiovato, L., Fenzi, G. F., ... Varrone, S. (1987). Increased level of thyroglobulin mRNA in a human familial goiter. Journal of Endocrinological Investigation, 10(1), 59-63. https://doi.org/10.1007/BF03347155

Increased level of thyroglobulin mRNA in a human familial goiter. / Monticelli, A.; Avvedimento, V. E.; Mariano, A.; Marcocci, C.; Chiovato, L.; Fenzi, G. F.; Pinchera, A.; Varrone, S.

In: Journal of Endocrinological Investigation, Vol. 10, No. 1, 1987, p. 59-63.

Research output: Contribution to journalArticle

Monticelli, A, Avvedimento, VE, Mariano, A, Marcocci, C, Chiovato, L, Fenzi, GF, Pinchera, A & Varrone, S 1987, 'Increased level of thyroglobulin mRNA in a human familial goiter', Journal of Endocrinological Investigation, vol. 10, no. 1, pp. 59-63. https://doi.org/10.1007/BF03347155
Monticelli, A. ; Avvedimento, V. E. ; Mariano, A. ; Marcocci, C. ; Chiovato, L. ; Fenzi, G. F. ; Pinchera, A. ; Varrone, S. / Increased level of thyroglobulin mRNA in a human familial goiter. In: Journal of Endocrinological Investigation. 1987 ; Vol. 10, No. 1. pp. 59-63.
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AU - Monticelli, A.

AU - Avvedimento, V. E.

AU - Mariano, A.

AU - Marcocci, C.

AU - Chiovato, L.

AU - Fenzi, G. F.

AU - Pinchera, A.

AU - Varrone, S.

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