Increased levels of C-reactive protein after oral hormone replacement therapy may not be related to an increased inflammatory response

Antonello Silvestri; Otavio Gebara; Cristiana Vitale; Mauricio Wajngarten; Filippo Leonardo; Josè A F Ramires; Massimo Fini; Giuseppe Mercuro; Giuseppe M C Rosano

doi:10.1161/01.CIR.0000074208.02226.5E

Increased levels of C-reactive protein after oral hormone replacement therapy may not be related to an increased inflammatory response

Antonello Silvestri, Otavio Gebara, Cristiana Vitale, Mauricio Wajngarten, Filippo Leonardo, Josè A F Ramires, Massimo Fini, Giuseppe Mercuro, Giuseppe M C Rosano

Istituto San Raffaele Pisana

Research output: Contribution to journal › Article

Abstract

Background - It has been suggested that hormone replacement therapy (HRT) in postmenopausal women is associated with an increased inflammatory response that may trigger acute cardiovascular events. This suggestion is mainly based on the finding of elevated C-reactive protein (CRP) levels after HRT. The aim of the present study was to evaluate a broad spectrum of vascular inflammation markers in 389 postmenopausal women with increased cardiovascular risk at baseline and after either 6 months of HRT (126 women) or no HRT (263 women). Methods and Results - Compared with baseline, CRP levels significantly increased after HRT (0.9±0.2 versus 1.6±0.4 mg/L, P

Original language	English
Pages (from-to)	3165-3169
Number of pages	5
Journal	Circulation
Volume	107
Issue number	25
DOIs	https://doi.org/10.1161/01.CIR.0000074208.02226.5E
Publication status	Published - Jul 1 2003

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Keywords

Cardiovascular diseases
Inflammation
Interleukins

ASJC Scopus subject areas

Physiology
Cardiology and Cardiovascular Medicine

Cite this

Silvestri, A., Gebara, O., Vitale, C., Wajngarten, M., Leonardo, F., Ramires, J. A. F., Fini, M., Mercuro, G., & Rosano, G. M. C. (2003). Increased levels of C-reactive protein after oral hormone replacement therapy may not be related to an increased inflammatory response. Circulation, 107(25), 3165-3169. https://doi.org/10.1161/01.CIR.0000074208.02226.5E

Increased levels of C-reactive protein after oral hormone replacement therapy may not be related to an increased inflammatory response. / Silvestri, Antonello; Gebara, Otavio; Vitale, Cristiana; Wajngarten, Mauricio; Leonardo, Filippo; Ramires, Josè A F; Fini, Massimo; Mercuro, Giuseppe; Rosano, Giuseppe M C.

In: Circulation, Vol. 107, No. 25, 01.07.2003, p. 3165-3169.

Research output: Contribution to journal › Article

Silvestri, Antonello ; Gebara, Otavio ; Vitale, Cristiana ; Wajngarten, Mauricio ; Leonardo, Filippo ; Ramires, Josè A F ; Fini, Massimo ; Mercuro, Giuseppe ; Rosano, Giuseppe M C. / Increased levels of C-reactive protein after oral hormone replacement therapy may not be related to an increased inflammatory response. In: Circulation. 2003 ; Vol. 107, No. 25. pp. 3165-3169.

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AU - Leonardo, Filippo

AU - Ramires, Josè A F

AU - Fini, Massimo

AU - Mercuro, Giuseppe

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Access to Document

10.1161/01.CIR.0000074208.02226.5E