Increased levels of C-reactive protein after oral hormone replacement therapy may not be related to an increased inflammatory response

Antonello Silvestri, Otavio Gebara, Cristiana Vitale, Mauricio Wajngarten, Filippo Leonardo, Josè A F Ramires, Massimo Fini, Giuseppe Mercuro, Giuseppe M C Rosano

Research output: Contribution to journalArticle

Abstract

Background - It has been suggested that hormone replacement therapy (HRT) in postmenopausal women is associated with an increased inflammatory response that may trigger acute cardiovascular events. This suggestion is mainly based on the finding of elevated C-reactive protein (CRP) levels after HRT. The aim of the present study was to evaluate a broad spectrum of vascular inflammation markers in 389 postmenopausal women with increased cardiovascular risk at baseline and after either 6 months of HRT (126 women) or no HRT (263 women). Methods and Results - Compared with baseline, CRP levels significantly increased after HRT (0.9±0.2 versus 1.6±0.4 mg/L, P

Original languageEnglish
Pages (from-to)3165-3169
Number of pages5
JournalCirculation
Volume107
Issue number25
DOIs
Publication statusPublished - Jul 1 2003

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Keywords

  • Cardiovascular diseases
  • Inflammation
  • Interleukins

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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