TY - JOUR
T1 - Increased levels of C-reactive protein after oral hormone replacement therapy may not be related to an increased inflammatory response
AU - Silvestri, Antonello
AU - Gebara, Otavio
AU - Vitale, Cristiana
AU - Wajngarten, Mauricio
AU - Leonardo, Filippo
AU - Ramires, Josè A F
AU - Fini, Massimo
AU - Mercuro, Giuseppe
AU - Rosano, Giuseppe M C
PY - 2003/7/1
Y1 - 2003/7/1
N2 - Background - It has been suggested that hormone replacement therapy (HRT) in postmenopausal women is associated with an increased inflammatory response that may trigger acute cardiovascular events. This suggestion is mainly based on the finding of elevated C-reactive protein (CRP) levels after HRT. The aim of the present study was to evaluate a broad spectrum of vascular inflammation markers in 389 postmenopausal women with increased cardiovascular risk at baseline and after either 6 months of HRT (126 women) or no HRT (263 women). Methods and Results - Compared with baseline, CRP levels significantly increased after HRT (0.9±0.2 versus 1.6±0.4 mg/L, P
AB - Background - It has been suggested that hormone replacement therapy (HRT) in postmenopausal women is associated with an increased inflammatory response that may trigger acute cardiovascular events. This suggestion is mainly based on the finding of elevated C-reactive protein (CRP) levels after HRT. The aim of the present study was to evaluate a broad spectrum of vascular inflammation markers in 389 postmenopausal women with increased cardiovascular risk at baseline and after either 6 months of HRT (126 women) or no HRT (263 women). Methods and Results - Compared with baseline, CRP levels significantly increased after HRT (0.9±0.2 versus 1.6±0.4 mg/L, P
KW - Cardiovascular diseases
KW - Inflammation
KW - Interleukins
UR - http://www.scopus.com/inward/record.url?scp=0038417544&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0038417544&partnerID=8YFLogxK
U2 - 10.1161/01.CIR.0000074208.02226.5E
DO - 10.1161/01.CIR.0000074208.02226.5E
M3 - Article
C2 - 12796135
AN - SCOPUS:0038417544
VL - 107
SP - 3165
EP - 3169
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 25
ER -