Increased levels of CSF heart-type fatty acid-binding protein and tau protein after aneurysmal subarachnoid hemorrhage

E. R. Zanier, L. Longhi, M. Fiorini, L. Cracco, A. Bersano, T. Zoerle, V. Branca, S. Monaco, N. Stocchetti

Research output: Chapter in Book/Report/Conference proceedingChapter


Background Heart-type Fatty Acid-Binding Protein (H-FABP) and tau protein (τ) have been shown to be novel biomarkers associated with brain injury and, therefore, they could represent a useful diagnostic tool in patients with subarachnoid hemorrhage (SAH). The goal of this study was to measure H-FABP and τ in cerebrospinal fluid (CSF) following SAH to test the hypothesis that a relationship exists between SAH severity and H-FABP/τ values. Methods Twenty-seven consecutive SAH patients admitted to our ICU were studied. Serial CSF samples were obtained in every patient starting on the day of SAH and daily for up to 2 weeks post-SAH. H-FABP/τ levels were measured by enzyme-linked immunosorbent assay. Results Patients with severe SAH showed significantly higher peak levels of H-FABP and τ compared to mild-SAH patients (FABP: p=0.02; τ: p=0.002). In addition the peak concentrations of H-FABP and τ in CSF from SAH patients correlated significantly with Glasgow Coma Scale motor score (H-FABP: Spearman r=-0.52, p=0.006; τ: Spearman r=-0.63, p=0.0004). Based on outcome at discharge from the hospital, patients were categorized into survivors and non-survivors. Peak concentrations of both proteins in the non-survivors group were significantly higher than in the survivors. Conclusions H-FABP and τ CSF levels are proportional to SAH severity and may be novel biomarkers that can be used to predict the severity of outcome following clinical SAH.

Original languageEnglish
Title of host publicationActa Neurochirurgica, Supplementum
Number of pages5
Publication statusPublished - 2008

Publication series

NameActa Neurochirurgica, Supplementum
ISSN (Print)00651419


  • Aneurysmal subarachnoid hemorrhage
  • Biomarkers
  • Heart-type fatty acid-binding protein
  • Tau protein

ASJC Scopus subject areas

  • Clinical Neurology
  • Surgery


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