Increased levels of serum MAP-2 at 6-months correlate with improved outcome in survivors of severe traumatic brain injury

Stefania Mondello, Andrea Gabrielli, Sheila Catani, Mariagrazia D'Ippolito, Andreas Jeromin, Antonio Ciaramella, Paola Bossù, Kara Schmid, Frank Tortella, Kevin K W Wang, Ronald L. Hayes, Rita Formisano

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate microtubule-associated proteins (MAP-2), a dendritic marker of both acute damage and chronic neuronal regeneration after injury, in serum of survivors after severe TBI and examine the association with long-term outcome. Methods: Serum concentrations of MAP-2 were evaluated in 16 patients with severe TBI (Glasgow Coma Scale score [GCS]≤8) 6 months post-injury and in 16 controls. Physical and cognitive outcomes were assessed, using the Glasgow Outcome Scale Extended (GOSE) and Levels of Cognitive Functioning Scale (LCFS), respectively. Results: Severe TBI patients had significantly higher serum MAP-2 concentrations than normal controls with no history of TBI (p=0.008) at 6 months post-injury. MAP-2 levels correlated with the GOSE (r=0.58, p=0.02) and LCFS (r=0.65, p=0.007) at month 6. Significantly lower serum levels of MAP-2 were observed in patients in a vegetative state (VS) compared to non-VS patients (p

Original languageEnglish
Pages (from-to)1629-1635
Number of pages7
JournalBrain Injury
Volume26
Issue number13-14
DOIs
Publication statusPublished - Dec 2012

Keywords

  • Biomarkers
  • Cognitive functioning
  • MAP2
  • Outcome
  • Traumatic brain injury

ASJC Scopus subject areas

  • Clinical Neurology
  • Arts and Humanities (miscellaneous)
  • Developmental and Educational Psychology

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    Mondello, S., Gabrielli, A., Catani, S., D'Ippolito, M., Jeromin, A., Ciaramella, A., Bossù, P., Schmid, K., Tortella, F., Wang, K. K. W., Hayes, R. L., & Formisano, R. (2012). Increased levels of serum MAP-2 at 6-months correlate with improved outcome in survivors of severe traumatic brain injury. Brain Injury, 26(13-14), 1629-1635. https://doi.org/10.3109/02699052.2012.700083