Increased levels of the CD40: CD40 ligand dyad in the cerebrospinal fluid of rats with vitamin B12(cobalamin)-deficient central neuropathy

Daniela Veber, Elena Mutti, Enrico Galmozzi, Sabrina Cedrola, Stefania Galbiati, Alberto Morabito, Giovanni Tredici, Caterina A. La Porta, Giuseppe Scalabrino

Research output: Contribution to journalArticlepeer-review

Abstract

The levels of the soluble (s) CD40:sCD40 ligand (L) dyad, which belongs to the tumor necrosis factor (TNF)-α:TNF-α-receptor superfamily, are significantly increased in the cerebrospinal fluid (CSF), but not the serum of cobalamin (Cbl)-deficient (Cbl-D) rats. They were normalized or significantly reduced after treatment with Cbl, transforming growth factor-β1 or S-adenosyl-l-methionine, and the normal myelin ultrastructure of the spinal cord was concomitantly restored. The concomitance of the two beneficial effects of these treatments strongly suggests that the increases in CSF sCD40:sCD40L levels may participate in the pathogenesis of purely myelinolytic Cbl-D central neuropathy in the rat. In keeping with this, an anti-CD40 treatment prevented myelin lesions.

Original languageEnglish
Pages (from-to)24-33
Number of pages10
JournalJournal of Neuroimmunology
Volume176
Issue number1-2
DOIs
Publication statusPublished - Jul 2006

Keywords

  • Cerebrospinal fluid
  • Cobalamin
  • Cobalamin-deficient neuropathy
  • Soluble CD40
  • Soluble CD40L
  • Vitamin B

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

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