Increased lipid peroxidation in adult GH-deficient patients: Effects of short-term GH administration

M. Scacchi, E. Valassi, A. I. Pincelli, L. M. Fatti, F. Pecori Giraldi, P. Ascoli, R. Viarengo, B. Cestaro, F. Cavagnini, R. Cazzola

Research output: Contribution to journalArticle

Abstract

Objective: Adult GH deficiency (GHD) syndrome characterized by increased risk of atherosclerosis and hence of cardio- and cerebrovascular mortality. Oxidative stress appears to play an important role in early atherogenesis. Oxidized LDL represents an important predictor of cardiovascular risk and is mainly responsible for oxidative damage of the endothelium. Its concentrations are increased in GHD, but the association between this abnormality and oxidative stress is still unclear, due to the discordant results yielded by the few available studies. Design and methods: In 13 GHD patients, plasma lipid peroxide concentrations were measured before and after a 4-month treatment with recombinant human GH (rhGH) and compared with those of 13 age- and sex-matched controls. In the same subjects, the so-called "lag-time", an index of anti-oxidant activity and thus of plasma oxidative balance, was also measured using a fluorescence kinetics method. Results: Before treatment, peroxide levels were significantly higher in patients than in controls (374.0±31.52 vs 268.0±8.51 U.C., p2= 0.62, p2=0.41, p

Original languageEnglish
Pages (from-to)899-904
Number of pages6
JournalJournal of Endocrinological Investigation
Volume29
Issue number10
Publication statusPublished - Nov 2006

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Keywords

  • Adult GH deficiency
  • GH therapy
  • Lipid peroxides

ASJC Scopus subject areas

  • Endocrinology

Cite this

Scacchi, M., Valassi, E., Pincelli, A. I., Fatti, L. M., Giraldi, F. P., Ascoli, P., Viarengo, R., Cestaro, B., Cavagnini, F., & Cazzola, R. (2006). Increased lipid peroxidation in adult GH-deficient patients: Effects of short-term GH administration. Journal of Endocrinological Investigation, 29(10), 899-904.