TY - JOUR
T1 - Increased lipid peroxidation in adult GH-deficient patients
T2 - Effects of short-term GH administration
AU - Scacchi, M.
AU - Valassi, E.
AU - Pincelli, A. I.
AU - Fatti, L. M.
AU - Giraldi, F. Pecori
AU - Ascoli, P.
AU - Viarengo, R.
AU - Cestaro, B.
AU - Cavagnini, F.
AU - Cazzola, R.
PY - 2006/11
Y1 - 2006/11
N2 - Objective: Adult GH deficiency (GHD) syndrome characterized by increased risk of atherosclerosis and hence of cardio- and cerebrovascular mortality. Oxidative stress appears to play an important role in early atherogenesis. Oxidized LDL represents an important predictor of cardiovascular risk and is mainly responsible for oxidative damage of the endothelium. Its concentrations are increased in GHD, but the association between this abnormality and oxidative stress is still unclear, due to the discordant results yielded by the few available studies. Design and methods: In 13 GHD patients, plasma lipid peroxide concentrations were measured before and after a 4-month treatment with recombinant human GH (rhGH) and compared with those of 13 age- and sex-matched controls. In the same subjects, the so-called "lag-time", an index of anti-oxidant activity and thus of plasma oxidative balance, was also measured using a fluorescence kinetics method. Results: Before treatment, peroxide levels were significantly higher in patients than in controls (374.0±31.52 vs 268.0±8.51 U.C., p2= 0.62, p2=0.41, p
AB - Objective: Adult GH deficiency (GHD) syndrome characterized by increased risk of atherosclerosis and hence of cardio- and cerebrovascular mortality. Oxidative stress appears to play an important role in early atherogenesis. Oxidized LDL represents an important predictor of cardiovascular risk and is mainly responsible for oxidative damage of the endothelium. Its concentrations are increased in GHD, but the association between this abnormality and oxidative stress is still unclear, due to the discordant results yielded by the few available studies. Design and methods: In 13 GHD patients, plasma lipid peroxide concentrations were measured before and after a 4-month treatment with recombinant human GH (rhGH) and compared with those of 13 age- and sex-matched controls. In the same subjects, the so-called "lag-time", an index of anti-oxidant activity and thus of plasma oxidative balance, was also measured using a fluorescence kinetics method. Results: Before treatment, peroxide levels were significantly higher in patients than in controls (374.0±31.52 vs 268.0±8.51 U.C., p2= 0.62, p2=0.41, p
KW - Adult GH deficiency
KW - GH therapy
KW - Lipid peroxides
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M3 - Article
C2 - 17185899
AN - SCOPUS:33846514275
VL - 29
SP - 899
EP - 904
JO - Journal of Endocrinological Investigation
JF - Journal of Endocrinological Investigation
SN - 0391-4097
IS - 10
ER -