Increased lipodystrophy is associated with increased exposure to highly active antiretroviral therapy in HIV-infected children

Alessandra Viganò, Stefano Mora, Corrado Testolin, Sabrina Beccio, Laura Schneider, Dorella Bricalli, Angelo Vanzulli, Paola Manzoni, Paolo Brambilla

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To assess body composition changes in HIV-infected children receiving highly active antiretroviral therapy (HAART). Methods: Thirty-seven HIV-positive children were enrolled. Dual-energy X-ray absorptiometry (DXA) scans were performed in all HIV-infected children at baseline and after an additional 12 months of HAART and in 54 matched (for sex, age, body mass index [BMI], and pubertal stage) healthy controls. Abdominal MRI was performed in 14 of 37 HIV-positive children at baseline and in 28 of 37 HIV-positive children after additional 12 months of HAART. Results: During the study period, mean HAART exposure increased from 39.3 to 50.9 months and the number of HIV-infected children with clinical lipodystrophy (LD) increased from 6 to 8, whereas mean BMI, CD4 percentage, and percentage of HIV-infected children with HIV RNA

Original languageEnglish
Pages (from-to)482-489
Number of pages8
JournalJournal of Acquired Immune Deficiency Syndromes
Volume32
Issue number5
DOIs
Publication statusPublished - Apr 15 2003

Keywords

  • HAART
  • HIV
  • Lipodystrophy
  • Ntra-abdominal adipose tissue

ASJC Scopus subject areas

  • Virology
  • Immunology

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