Increased lymphocyte dopamine β-hydroxylase immunoreactivity in Alzheimer's disease: Compensatory response to cholinergic deficit?

Franco Giubilei; Caterina Calderaro; Giovanni Antonini; Micaela Sepe-Monti; Paolo Tisei; Ercole Brunetti; Francesca Marchione; Brunella Caronti; Francesco E. Pontieri

doi:10.1159/000080128

Increased lymphocyte dopamine β-hydroxylase immunoreactivity in Alzheimer's disease: Compensatory response to cholinergic deficit?

Franco Giubilei, Caterina Calderaro, Giovanni Antonini, Micaela Sepe-Monti, Paolo Tisei, Ercole Brunetti, Francesca Marchione, Brunella Caronti, Francesco E. Pontieri

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

There is growing interest in the characterization of peripheral blood lymphocytes (PBL) as a biological tool with which to investigate changes in the neurotransmitter-receptor system in neurodegenerative disorders. Here we show a slight decrease in acetylcholinesterase (AChE) and a significant increase in dopamine β-hydroxylase (DBH) immunoreactivity in the PBL of patients with probable Alzheimer's disease (AD). Therapy with AChE inhibitors completely reversed the increase in DBH immunoreactivity. We hypothesize that the increase in DBH immunoreactivity may represent a compensatory response to cholinergic impairment. Our findings suggest that neurochemical interactions between the noradrenergic and cholinergic systems may be measured at a peripheral level in AD.

Original language	English
Pages (from-to)	338-341
Number of pages	4
Journal	Dementia and Geriatric Cognitive Disorders
Volume	18
Issue number	3-4
DOIs	https://doi.org/10.1159/000080128
Publication status	Published - 2004

Keywords

Alzheimer's disease
Dopamine β-hydroxylase
Immunocytochemistry
Peripheral blood lymphocytes

ASJC Scopus subject areas

Neuropsychology and Physiological Psychology
Geriatrics and Gerontology

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Increased lymphocyte dopamine β-hydroxylase immunoreactivity in Alzheimer's disease : Compensatory response to cholinergic deficit? / Giubilei, Franco; Calderaro, Caterina; Antonini, Giovanni; Sepe-Monti, Micaela; Tisei, Paolo; Brunetti, Ercole; Marchione, Francesca; Caronti, Brunella; Pontieri, Francesco E.

In: Dementia and Geriatric Cognitive Disorders, Vol. 18, No. 3-4, 2004, p. 338-341.

Research output: Contribution to journal › Article › peer-review

Giubilei, Franco ; Calderaro, Caterina ; Antonini, Giovanni ; Sepe-Monti, Micaela ; Tisei, Paolo ; Brunetti, Ercole ; Marchione, Francesca ; Caronti, Brunella ; Pontieri, Francesco E. / Increased lymphocyte dopamine β-hydroxylase immunoreactivity in Alzheimer's disease : Compensatory response to cholinergic deficit?. In: Dementia and Geriatric Cognitive Disorders. 2004 ; Vol. 18, No. 3-4. pp. 338-341.

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Increased lymphocyte dopamine β-hydroxylase immunoreactivity in Alzheimer's disease: Compensatory response to cholinergic deficit?

Abstract

Keywords

ASJC Scopus subject areas

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