Increased mammographic breast density in acromegaly: Quantitative and qualitative assessment

Alberto Tagliafico, Massimo Calabrese, Giulio Tagliafico, Eugenia Resmini, Carlo Martinoli, Alberto Rebora, Annamaria Colao, Rosario Pivonello, Diego Ferone

Research output: Contribution to journalArticlepeer-review


Context: Mammographic density is a strong independent risk factor for breast cancer, whose prevalence in acromegaly is still controversial. Objective: To compare breast density in premenopausal acromegalic patients and controls and to determine whether density correlated with disease duration, GH, and IGF1 levels. Design, setting and participants: A prospective study involving 30 patients and 60 controls matched for age and body mass index. Interventions: A quantitative computer-aided mammographic density estimation (MDEST) and a qualitative blind evaluation by two experienced radiologists using the breast imaging reporting and data system (BI-RADS) was performed. Totally, 60 (acromegaly) and 120 (controls) craniocaudal and mediolateral oblique mammograms were evaluated in both patients and controls. Main outcome measures: Breast density. Results: Patients showed a significantly (P

Original languageEnglish
Pages (from-to)335-340
Number of pages6
JournalEuropean Journal of Endocrinology
Issue number3
Publication statusPublished - Mar 1 2011

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)


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