Increased mammographic breast density in acromegaly: Quantitative and qualitative assessment

Alberto Tagliafico, Massimo Calabrese, Giulio Tagliafico, Eugenia Resmini, Carlo Martinoli, Alberto Rebora, Annamaria Colao, Rosario Pivonello, Diego Ferone

Research output: Contribution to journalArticle

Abstract

Context: Mammographic density is a strong independent risk factor for breast cancer, whose prevalence in acromegaly is still controversial. Objective: To compare breast density in premenopausal acromegalic patients and controls and to determine whether density correlated with disease duration, GH, and IGF1 levels. Design, setting and participants: A prospective study involving 30 patients and 60 controls matched for age and body mass index. Interventions: A quantitative computer-aided mammographic density estimation (MDEST) and a qualitative blind evaluation by two experienced radiologists using the breast imaging reporting and data system (BI-RADS) was performed. Totally, 60 (acromegaly) and 120 (controls) craniocaudal and mediolateral oblique mammograms were evaluated in both patients and controls. Main outcome measures: Breast density. Results: Patients showed a significantly (P

Original languageEnglish
Pages (from-to)335-340
Number of pages6
JournalEuropean Journal of Endocrinology
Volume164
Issue number3
DOIs
Publication statusPublished - Mar 1 2011

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ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

Cite this

Tagliafico, A., Calabrese, M., Tagliafico, G., Resmini, E., Martinoli, C., Rebora, A., Colao, A., Pivonello, R., & Ferone, D. (2011). Increased mammographic breast density in acromegaly: Quantitative and qualitative assessment. European Journal of Endocrinology, 164(3), 335-340. https://doi.org/10.1530/EJE-10-0896