Increased monocyte phagocytosis in cancer patients

L. P. Ruco, A. Procopio, S. Uccini, C. D. Baroni

Research output: Contribution to journalArticle

Abstract

Phagocytosis of IgG opsonized sheep erythrocytes (EA) by peripheral blood monocytes was evaluated in 73 individuals: 29 patients with malignant neoplastic diseases, 24 patients with non-malignant diseases and 20 normal donors. In a 30-min assay, phagocytosis values observed in 16 of 29 cancer patients and in 3 of 24 control patients were above the upper limit of the 2 S.D. interval for the normal donor population. The enhanced EA phagocytosis was dependent on a higher percentage of phagocytic cells as well as on an increased phagocytic rate. Mean values of phagocytosis obtained for cancer patients were statistically different (P <0.01) from those obtained for normal donors and control patients. According to a still limited number of observations, no association could be demonstrated between increased monocyte phagocytosis and histological type, anatomical site and clinical stage of the tumors.

Original languageEnglish
Pages (from-to)1315-1320
Number of pages6
JournalEuropean Journal of Cancer and Clinical Oncology
Volume16
Issue number10
Publication statusPublished - 1980

ASJC Scopus subject areas

  • Oncology

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