Increased mortality and aggravation of heart failure in estrogen receptor-β knockout mice after myocardial infarction

Theo Pelzer, Paula Anahi Arias Loza, Kai Hu, Barbara Bayer, Charlotte Dienesch, Laura Calvillo, John F. Couse, Kenneth S. Korach, Ludwig Neyses, Georg Ertl

Research output: Contribution to journalArticle

Abstract

Background - Lower mortality rates among women with chronic heart failure than among men may depend in part on the action of female sex hormones, especially estrogens. The biological effects of estrogens are mediated by 2 distinct estrogen receptor (ER) subtypes (ERα and ERβ). The present study was undertaken to determine the role of ERβ in the development of chronic heart failure after experimental myocardial infarction (MI). Methods and Results - Female ERβ null mice (BERKOchapel Hill) and wild-type littermates (WT) were ovariectomized, given 17β-estradiol, and subjected to chronic anterior MI (MI; BERKO n=31, WT n=30) or sham operation (sham; BERKO n=14, WT n=14). At 8 weeks after MI, both genotypes revealed left ventricular remodeling and impaired contractile function at similar average infarct size (BERKO-MI 32.9±5% versus WT-MI 33.0±4%); however, BERKO mice showed increased mortality (BERKO-MI 42% versus WT-MI 23%), increased body weight and fluid retention (P2+-handling proteins in chronic heart failure after MI. Further studies are required to delineate the relative importance of cardiac and vascular effects of ERβ and the role of ERα in the development of heart failure.

Original languageEnglish
Pages (from-to)1492-1498
Number of pages7
JournalCirculation
Volume111
Issue number12
DOIs
Publication statusPublished - Mar 29 2005

Keywords

  • Heart failure
  • Hormones
  • Myocardial infarction
  • Receptors

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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    Pelzer, T., Loza, P. A. A., Hu, K., Bayer, B., Dienesch, C., Calvillo, L., Couse, J. F., Korach, K. S., Neyses, L., & Ertl, G. (2005). Increased mortality and aggravation of heart failure in estrogen receptor-β knockout mice after myocardial infarction. Circulation, 111(12), 1492-1498. https://doi.org/10.1161/01.CIR.0000159262.18512.46