Increased mortality in young candidemia patients associated with presence of a Candida albicans general-purpose genotype

J. Schmid, A. M. Tortorano, G. Jones, C. Lazzarini, N. Zhang, M. J. Bendall, M. Cogliati, S. Wattimena, L. Klingspor, Claire Bouges-Michel, Isabelle Poilane, Marie Elisabeth Bougnoux, Jean Dunand, Guy Galeazzi, Stéphane Bretagne, Nathalie Fauchet, Elisabeth Forget, Françoise Botterel, Christine Bonnal, Odile EloyChristine Lawrence, Marie Françoise David, Liliana Mihaila, Elisabeth Chachaty, Olivier Adam, Christian Chochillon, André Paugam, Marie Thérèse Baixench, Muriel Cornet, Marie Christine Escande, Svetlana Challier, Eric Dannaoui, Annick Datry, Houria Laklache, Bader Lminmouni, Sophie Brun, Jean Louis Poirot, Claire Lacroix, Didier Moissenet, Michel Develoux, Stéphane Bonacorsi, Anna Maria Tortorano, Giovanna Dho, Anna Prigitano, Anna Grancini, Cristina Ossi, Giuseppe Giuliani, Milvana Tejada, Chiara Vismara, Giovanna Viola, Caterina Cavanna, Marco Passera, Claudio Farina, Antonio Grossi, Gabriele Pinsi, Antonio Ceraminiello, Pietro Casella, Carlo Agrappi, Carla Sturla, Gianluigi Lombardi, Giuliana LoCascio, Maria Luisa Deiana, Maria Graziella Garau, Lean Klingspor, Andrea Weigel, Barbara Graf, Markus Ruhnke, Javier Peman, Juha H. Salonen, Olli Meurman, Hannu Sarkkinen, Raquel Sabino, Zélia Videira, Harald Kirschner, Cornelia Lass-Flörl, Matthias Maass, Regina Watschinger, Birgit Willinger, Eva Maria Zeitlberger, Aristea Velegraki, Stavroula Antonopoulou, George Dimopoulos, Evangelia Kouskouni, Efthimia Petinaki, Eleftheria Trikka-Graphakos, A. Timoleon Vyzantiadis, Loukia Zerva

Research output: Contribution to journalArticlepeer-review

Abstract

The yeast Candida albicans causes life-threatening candidemia. A general-purpose genotype (GPG; corresponds to clade 1) causes more infections than other C. albicans genotypes. To investigate if GPG strains also cause higher mortality, we developed a duplex PCR assay which was 98% accurate in identifying GPG strains in an international collection of strains typed with probe Ca3. We applied the assay to 635 European C. albicans candidemia isolates. Of these, 18% conformed to the GPG genotype, 4% were of a borderline genotype, and 78% were of a non-GPG genotype, broadly consistent with genotype distributions in earlier studies. The prevalence of GPG strains was increased in females and in younger patients, exceeding 40% in infants aged

Original languageEnglish
Pages (from-to)3250-3256
Number of pages7
JournalJournal of Clinical Microbiology
Volume49
Issue number9
DOIs
Publication statusPublished - Sep 2011

ASJC Scopus subject areas

  • Microbiology (medical)

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