Increased mortality in young candidemia patients associated with presence of a Candida albicans general-purpose genotype

J. Schmid; A. M. Tortorano; G. Jones; C. Lazzarini; N. Zhang; M. J. Bendall; M. Cogliati; S. Wattimena; L. Klingspor; Claire Bouges-Michel; Isabelle Poilane; Marie Elisabeth Bougnoux; Jean Dunand; Guy Galeazzi; Stéphane Bretagne; Nathalie Fauchet; Elisabeth Forget; Françoise Botterel; Christine Bonnal; Odile Eloy; Christine Lawrence; Marie Françoise David; Liliana Mihaila; Elisabeth Chachaty; Olivier Adam; Christian Chochillon; André Paugam; Marie Thérèse Baixench; Muriel Cornet; Marie Christine Escande; Svetlana Challier; Eric Dannaoui; Annick Datry; Houria Laklache; Bader Lminmouni; Sophie Brun; Jean Louis Poirot; Claire Lacroix; Didier Moissenet; Michel Develoux; Stéphane Bonacorsi; Anna Maria Tortorano; Giovanna Dho; Anna Prigitano; Anna Grancini; Cristina Ossi; Giuseppe Giuliani; Milvana Tejada; Chiara Vismara; Giovanna Viola; Caterina Cavanna; Marco Passera; Claudio Farina; Antonio Grossi; Gabriele Pinsi; Antonio Ceraminiello; Pietro Casella; Carlo Agrappi; Carla Sturla; Gianluigi Lombardi; Giuliana LoCascio; Maria Luisa Deiana; Maria Graziella Garau; Lean Klingspor; Andrea Weigel; Barbara Graf; Markus Ruhnke; Javier Peman; Juha H. Salonen; Olli Meurman; Hannu Sarkkinen; Raquel Sabino; Zélia Videira; Harald Kirschner; Cornelia Lass-Flörl; Matthias Maass; Regina Watschinger; Birgit Willinger; Eva Maria Zeitlberger; Aristea Velegraki; Stavroula Antonopoulou; George Dimopoulos; Evangelia Kouskouni; Efthimia Petinaki; Eleftheria Trikka-Graphakos; A. Timoleon Vyzantiadis; Loukia Zerva

doi:10.1128/JCM.00941-11

Increased mortality in young candidemia patients associated with presence of a Candida albicans general-purpose genotype

J. Schmid, A. M. Tortorano, G. Jones, C. Lazzarini, N. Zhang, M. J. Bendall, M. Cogliati, S. Wattimena, L. Klingspor, Claire Bouges-Michel, Isabelle Poilane, Marie Elisabeth Bougnoux, Jean Dunand, Guy Galeazzi, Stéphane Bretagne, Nathalie Fauchet, Elisabeth Forget, Françoise Botterel, Christine Bonnal, Odile EloyChristine Lawrence, Marie Françoise David, Liliana Mihaila, Elisabeth Chachaty, Olivier Adam, Christian Chochillon, André Paugam, Marie Thérèse Baixench, Muriel Cornet, Marie Christine Escande, Svetlana Challier, Eric Dannaoui, Annick Datry, Houria Laklache, Bader Lminmouni, Sophie Brun, Jean Louis Poirot, Claire Lacroix, Didier Moissenet, Michel Develoux, Stéphane Bonacorsi, Anna Maria Tortorano, Giovanna Dho, Anna Prigitano, Anna Grancini, Cristina Ossi, Giuseppe Giuliani, Milvana Tejada, Chiara Vismara, Giovanna Viola, Caterina Cavanna, Marco Passera, Claudio Farina, Antonio Grossi, Gabriele Pinsi, Antonio Ceraminiello, Pietro Casella, Carlo Agrappi, Carla Sturla, Gianluigi Lombardi, Giuliana LoCascio, Maria Luisa Deiana, Maria Graziella Garau, Lean Klingspor, Andrea Weigel, Barbara Graf, Markus Ruhnke, Javier Peman, Juha H. Salonen, Olli Meurman, Hannu Sarkkinen, Raquel Sabino, Zélia Videira, Harald Kirschner, Cornelia Lass-Flörl, Matthias Maass, Regina Watschinger, Birgit Willinger, Eva Maria Zeitlberger, Aristea Velegraki, Stavroula Antonopoulou, George Dimopoulos, Evangelia Kouskouni, Efthimia Petinaki, Eleftheria Trikka-Graphakos, A. Timoleon Vyzantiadis, Loukia Zerva

Research output: Contribution to journal › Article › peer-review

Abstract

The yeast Candida albicans causes life-threatening candidemia. A general-purpose genotype (GPG; corresponds to clade 1) causes more infections than other C. albicans genotypes. To investigate if GPG strains also cause higher mortality, we developed a duplex PCR assay which was 98% accurate in identifying GPG strains in an international collection of strains typed with probe Ca3. We applied the assay to 635 European C. albicans candidemia isolates. Of these, 18% conformed to the GPG genotype, 4% were of a borderline genotype, and 78% were of a non-GPG genotype, broadly consistent with genotype distributions in earlier studies. The prevalence of GPG strains was increased in females and in younger patients, exceeding 40% in infants aged

Original language	English
Pages (from-to)	3250-3256
Number of pages	7
Journal	Journal of Clinical Microbiology
Volume	49
Issue number	9
DOIs	https://doi.org/10.1128/JCM.00941-11
Publication status	Published - Sep 2011

ASJC Scopus subject areas

Microbiology (medical)

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10.1128/JCM.00941-11

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Schmid, J., Tortorano, A. M., Jones, G., Lazzarini, C., Zhang, N., Bendall, M. J., Cogliati, M., Wattimena, S., Klingspor, L., Bouges-Michel, C., Poilane, I., Bougnoux, M. E., Dunand, J., Galeazzi, G., Bretagne, S., Fauchet, N., Forget, E., Botterel, F., Bonnal, C., ... Zerva, L. (2011). Increased mortality in young candidemia patients associated with presence of a Candida albicans general-purpose genotype. Journal of Clinical Microbiology, 49(9), 3250-3256. https://doi.org/10.1128/JCM.00941-11

Increased mortality in young candidemia patients associated with presence of a Candida albicans general-purpose genotype. / Schmid, J.; Tortorano, A. M.; Jones, G.; Lazzarini, C.; Zhang, N.; Bendall, M. J.; Cogliati, M.; Wattimena, S.; Klingspor, L.; Bouges-Michel, Claire; Poilane, Isabelle; Bougnoux, Marie Elisabeth; Dunand, Jean; Galeazzi, Guy; Bretagne, Stéphane; Fauchet, Nathalie; Forget, Elisabeth; Botterel, Françoise; Bonnal, Christine; Eloy, Odile; Lawrence, Christine; David, Marie Françoise; Mihaila, Liliana; Chachaty, Elisabeth; Adam, Olivier; Chochillon, Christian; Paugam, André; Baixench, Marie Thérèse; Cornet, Muriel; Escande, Marie Christine; Challier, Svetlana; Dannaoui, Eric; Datry, Annick; Laklache, Houria; Lminmouni, Bader; Brun, Sophie; Poirot, Jean Louis; Lacroix, Claire; Moissenet, Didier; Develoux, Michel; Bonacorsi, Stéphane; Tortorano, Anna Maria; Dho, Giovanna; Prigitano, Anna; Grancini, Anna; Ossi, Cristina; Giuliani, Giuseppe; Tejada, Milvana; Vismara, Chiara; Viola, Giovanna; Cavanna, Caterina; Passera, Marco; Farina, Claudio; Grossi, Antonio; Pinsi, Gabriele; Ceraminiello, Antonio; Casella, Pietro; Agrappi, Carlo; Sturla, Carla; Lombardi, Gianluigi; LoCascio, Giuliana; Deiana, Maria Luisa; Garau, Maria Graziella; Klingspor, Lean; Weigel, Andrea; Graf, Barbara; Ruhnke, Markus; Peman, Javier; Salonen, Juha H.; Meurman, Olli; Sarkkinen, Hannu; Sabino, Raquel; Videira, Zélia; Kirschner, Harald; Lass-Flörl, Cornelia; Maass, Matthias; Watschinger, Regina; Willinger, Birgit; Zeitlberger, Eva Maria; Velegraki, Aristea; Antonopoulou, Stavroula; Dimopoulos, George; Kouskouni, Evangelia; Petinaki, Efthimia; Trikka-Graphakos, Eleftheria; Vyzantiadis, A. Timoleon; Zerva, Loukia.

In: Journal of Clinical Microbiology, Vol. 49, No. 9, 09.2011, p. 3250-3256.

Research output: Contribution to journal › Article › peer-review

Schmid, J, Tortorano, AM, Jones, G, Lazzarini, C, Zhang, N, Bendall, MJ, Cogliati, M, Wattimena, S, Klingspor, L, Bouges-Michel, C, Poilane, I, Bougnoux, ME, Dunand, J, Galeazzi, G, Bretagne, S, Fauchet, N, Forget, E, Botterel, F, Bonnal, C, Eloy, O, Lawrence, C, David, MF, Mihaila, L, Chachaty, E, Adam, O, Chochillon, C, Paugam, A, Baixench, MT, Cornet, M, Escande, MC, Challier, S, Dannaoui, E, Datry, A, Laklache, H, Lminmouni, B, Brun, S, Poirot, JL, Lacroix, C, Moissenet, D, Develoux, M, Bonacorsi, S, Tortorano, AM, Dho, G, Prigitano, A, Grancini, A, Ossi, C, Giuliani, G, Tejada, M, Vismara, C, Viola, G, Cavanna, C, Passera, M, Farina, C, Grossi, A, Pinsi, G, Ceraminiello, A, Casella, P, Agrappi, C, Sturla, C, Lombardi, G, LoCascio, G, Deiana, ML, Garau, MG, Klingspor, L, Weigel, A, Graf, B, Ruhnke, M, Peman, J, Salonen, JH, Meurman, O, Sarkkinen, H, Sabino, R, Videira, Z, Kirschner, H, Lass-Flörl, C, Maass, M, Watschinger, R, Willinger, B, Zeitlberger, EM, Velegraki, A, Antonopoulou, S, Dimopoulos, G, Kouskouni, E, Petinaki, E, Trikka-Graphakos, E, Vyzantiadis, AT & Zerva, L 2011, 'Increased mortality in young candidemia patients associated with presence of a Candida albicans general-purpose genotype', Journal of Clinical Microbiology, vol. 49, no. 9, pp. 3250-3256. https://doi.org/10.1128/JCM.00941-11

Schmid, J. ; Tortorano, A. M. ; Jones, G. ; Lazzarini, C. ; Zhang, N. ; Bendall, M. J. ; Cogliati, M. ; Wattimena, S. ; Klingspor, L. ; Bouges-Michel, Claire ; Poilane, Isabelle ; Bougnoux, Marie Elisabeth ; Dunand, Jean ; Galeazzi, Guy ; Bretagne, Stéphane ; Fauchet, Nathalie ; Forget, Elisabeth ; Botterel, Françoise ; Bonnal, Christine ; Eloy, Odile ; Lawrence, Christine ; David, Marie Françoise ; Mihaila, Liliana ; Chachaty, Elisabeth ; Adam, Olivier ; Chochillon, Christian ; Paugam, André ; Baixench, Marie Thérèse ; Cornet, Muriel ; Escande, Marie Christine ; Challier, Svetlana ; Dannaoui, Eric ; Datry, Annick ; Laklache, Houria ; Lminmouni, Bader ; Brun, Sophie ; Poirot, Jean Louis ; Lacroix, Claire ; Moissenet, Didier ; Develoux, Michel ; Bonacorsi, Stéphane ; Tortorano, Anna Maria ; Dho, Giovanna ; Prigitano, Anna ; Grancini, Anna ; Ossi, Cristina ; Giuliani, Giuseppe ; Tejada, Milvana ; Vismara, Chiara ; Viola, Giovanna ; Cavanna, Caterina ; Passera, Marco ; Farina, Claudio ; Grossi, Antonio ; Pinsi, Gabriele ; Ceraminiello, Antonio ; Casella, Pietro ; Agrappi, Carlo ; Sturla, Carla ; Lombardi, Gianluigi ; LoCascio, Giuliana ; Deiana, Maria Luisa ; Garau, Maria Graziella ; Klingspor, Lean ; Weigel, Andrea ; Graf, Barbara ; Ruhnke, Markus ; Peman, Javier ; Salonen, Juha H. ; Meurman, Olli ; Sarkkinen, Hannu ; Sabino, Raquel ; Videira, Zélia ; Kirschner, Harald ; Lass-Flörl, Cornelia ; Maass, Matthias ; Watschinger, Regina ; Willinger, Birgit ; Zeitlberger, Eva Maria ; Velegraki, Aristea ; Antonopoulou, Stavroula ; Dimopoulos, George ; Kouskouni, Evangelia ; Petinaki, Efthimia ; Trikka-Graphakos, Eleftheria ; Vyzantiadis, A. Timoleon ; Zerva, Loukia. / Increased mortality in young candidemia patients associated with presence of a Candida albicans general-purpose genotype. In: Journal of Clinical Microbiology. 2011 ; Vol. 49, No. 9. pp. 3250-3256.

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title = "Increased mortality in young candidemia patients associated with presence of a Candida albicans general-purpose genotype",

abstract = "The yeast Candida albicans causes life-threatening candidemia. A general-purpose genotype (GPG; corresponds to clade 1) causes more infections than other C. albicans genotypes. To investigate if GPG strains also cause higher mortality, we developed a duplex PCR assay which was 98% accurate in identifying GPG strains in an international collection of strains typed with probe Ca3. We applied the assay to 635 European C. albicans candidemia isolates. Of these, 18% conformed to the GPG genotype, 4% were of a borderline genotype, and 78% were of a non-GPG genotype, broadly consistent with genotype distributions in earlier studies. The prevalence of GPG strains was increased in females and in younger patients, exceeding 40% in infants aged ",

author = "J. Schmid and Tortorano, {A. M.} and G. Jones and C. Lazzarini and N. Zhang and Bendall, {M. J.} and M. Cogliati and S. Wattimena and L. Klingspor and Claire Bouges-Michel and Isabelle Poilane and Bougnoux, {Marie Elisabeth} and Jean Dunand and Guy Galeazzi and St{\'e}phane Bretagne and Nathalie Fauchet and Elisabeth Forget and Fran{\c c}oise Botterel and Christine Bonnal and Odile Eloy and Christine Lawrence and David, {Marie Fran{\c c}oise} and Liliana Mihaila and Elisabeth Chachaty and Olivier Adam and Christian Chochillon and Andr{\'e} Paugam and Baixench, {Marie Th{\'e}r{\`e}se} and Muriel Cornet and Escande, {Marie Christine} and Svetlana Challier and Eric Dannaoui and Annick Datry and Houria Laklache and Bader Lminmouni and Sophie Brun and Poirot, {Jean Louis} and Claire Lacroix and Didier Moissenet and Michel Develoux and St{\'e}phane Bonacorsi and Tortorano, {Anna Maria} and Giovanna Dho and Anna Prigitano and Anna Grancini and Cristina Ossi and Giuseppe Giuliani and Milvana Tejada and Chiara Vismara and Giovanna Viola and Caterina Cavanna and Marco Passera and Claudio Farina and Antonio Grossi and Gabriele Pinsi and Antonio Ceraminiello and Pietro Casella and Carlo Agrappi and Carla Sturla and Gianluigi Lombardi and Giuliana LoCascio and Deiana, {Maria Luisa} and Garau, {Maria Graziella} and Lean Klingspor and Andrea Weigel and Barbara Graf and Markus Ruhnke and Javier Peman and Salonen, {Juha H.} and Olli Meurman and Hannu Sarkkinen and Raquel Sabino and Z{\'e}lia Videira and Harald Kirschner and Cornelia Lass-Fl{\"o}rl and Matthias Maass and Regina Watschinger and Birgit Willinger and Zeitlberger, {Eva Maria} and Aristea Velegraki and Stavroula Antonopoulou and George Dimopoulos and Evangelia Kouskouni and Efthimia Petinaki and Eleftheria Trikka-Graphakos and Vyzantiadis, {A. Timoleon} and Loukia Zerva",

year = "2011",

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doi = "10.1128/JCM.00941-11",

language = "English",

volume = "49",

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journal = "Journal of Clinical Microbiology",

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T1 - Increased mortality in young candidemia patients associated with presence of a Candida albicans general-purpose genotype

AU - Schmid, J.

AU - Tortorano, A. M.

AU - Jones, G.

AU - Lazzarini, C.

AU - Zhang, N.

AU - Bendall, M. J.

AU - Cogliati, M.

AU - Wattimena, S.

AU - Klingspor, L.

AU - Bouges-Michel, Claire

AU - Poilane, Isabelle

AU - Bougnoux, Marie Elisabeth

AU - Dunand, Jean

AU - Galeazzi, Guy

AU - Bretagne, Stéphane

AU - Fauchet, Nathalie

AU - Forget, Elisabeth

AU - Botterel, Françoise

AU - Bonnal, Christine

AU - Eloy, Odile

AU - Lawrence, Christine

AU - David, Marie Françoise

AU - Mihaila, Liliana

AU - Chachaty, Elisabeth

AU - Adam, Olivier

AU - Chochillon, Christian

AU - Paugam, André

AU - Baixench, Marie Thérèse

AU - Cornet, Muriel

AU - Escande, Marie Christine

AU - Challier, Svetlana

AU - Dannaoui, Eric

AU - Datry, Annick

AU - Laklache, Houria

AU - Lminmouni, Bader

AU - Brun, Sophie

AU - Poirot, Jean Louis

AU - Lacroix, Claire

AU - Moissenet, Didier

AU - Develoux, Michel

AU - Bonacorsi, Stéphane

AU - Tortorano, Anna Maria

AU - Dho, Giovanna

AU - Prigitano, Anna

AU - Grancini, Anna

AU - Ossi, Cristina

AU - Giuliani, Giuseppe

AU - Tejada, Milvana

AU - Vismara, Chiara

AU - Viola, Giovanna

AU - Cavanna, Caterina

AU - Passera, Marco

AU - Farina, Claudio

AU - Grossi, Antonio

AU - Pinsi, Gabriele

AU - Ceraminiello, Antonio

AU - Casella, Pietro

AU - Agrappi, Carlo

AU - Sturla, Carla

AU - Lombardi, Gianluigi

AU - LoCascio, Giuliana

AU - Deiana, Maria Luisa

AU - Garau, Maria Graziella

AU - Klingspor, Lean

AU - Weigel, Andrea

AU - Graf, Barbara

AU - Ruhnke, Markus

AU - Peman, Javier

AU - Salonen, Juha H.

AU - Meurman, Olli

AU - Sarkkinen, Hannu

AU - Sabino, Raquel

AU - Videira, Zélia

AU - Kirschner, Harald

AU - Lass-Flörl, Cornelia

AU - Maass, Matthias

AU - Watschinger, Regina

AU - Willinger, Birgit

AU - Zeitlberger, Eva Maria

AU - Velegraki, Aristea

AU - Antonopoulou, Stavroula

AU - Dimopoulos, George

AU - Kouskouni, Evangelia

AU - Petinaki, Efthimia

AU - Trikka-Graphakos, Eleftheria

AU - Vyzantiadis, A. Timoleon

AU - Zerva, Loukia

PY - 2011/9

Y1 - 2011/9

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AB - The yeast Candida albicans causes life-threatening candidemia. A general-purpose genotype (GPG; corresponds to clade 1) causes more infections than other C. albicans genotypes. To investigate if GPG strains also cause higher mortality, we developed a duplex PCR assay which was 98% accurate in identifying GPG strains in an international collection of strains typed with probe Ca3. We applied the assay to 635 European C. albicans candidemia isolates. Of these, 18% conformed to the GPG genotype, 4% were of a borderline genotype, and 78% were of a non-GPG genotype, broadly consistent with genotype distributions in earlier studies. The prevalence of GPG strains was increased in females and in younger patients, exceeding 40% in infants aged

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AN - SCOPUS:80052218564

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JO - Journal of Clinical Microbiology

JF - Journal of Clinical Microbiology

SN - 0095-1137

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ER -

Increased mortality in young candidemia patients associated with presence of a Candida albicans general-purpose genotype

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