Abstract
The yeast Candida albicans causes life-threatening candidemia. A general-purpose genotype (GPG; corresponds to clade 1) causes more infections than other C. albicans genotypes. To investigate if GPG strains also cause higher mortality, we developed a duplex PCR assay which was 98% accurate in identifying GPG strains in an international collection of strains typed with probe Ca3. We applied the assay to 635 European C. albicans candidemia isolates. Of these, 18% conformed to the GPG genotype, 4% were of a borderline genotype, and 78% were of a non-GPG genotype, broadly consistent with genotype distributions in earlier studies. The prevalence of GPG strains was increased in females and in younger patients, exceeding 40% in infants aged
Original language | English |
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Pages (from-to) | 3250-3256 |
Number of pages | 7 |
Journal | Journal of Clinical Microbiology |
Volume | 49 |
Issue number | 9 |
DOIs | |
Publication status | Published - Sep 2011 |
ASJC Scopus subject areas
- Microbiology (medical)