Abstract
The yeast Candida albicans causes life-threatening candidemia. A general-purpose genotype (GPG; corresponds to clade 1) causes more infections than other C. albicans genotypes. To investigate if GPG strains also cause higher mortality, we developed a duplex PCR assay which was 98% accurate in identifying GPG strains in an international collection of strains typed with probe Ca3. We applied the assay to 635 European C. albicans candidemia isolates. Of these, 18% conformed to the GPG genotype, 4% were of a borderline genotype, and 78% were of a non-GPG genotype, broadly consistent with genotype distributions in earlier studies. The prevalence of GPG strains was increased in females and in younger patients, exceeding 40% in infants aged
| Original language | English |
|---|---|
| Pages (from-to) | 3250-3256 |
| Number of pages | 7 |
| Journal | Journal of Clinical Microbiology |
| Volume | 49 |
| Issue number | 9 |
| DOIs | |
| Publication status | Published - Sep 2011 |
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ASJC Scopus subject areas
- Microbiology (medical)
Cite this
Increased mortality in young candidemia patients associated with presence of a Candida albicans general-purpose genotype. / Schmid, J.; Tortorano, A. M.; Jones, G.; Lazzarini, C.; Zhang, N.; Bendall, M. J.; Cogliati, M.; Wattimena, S.; Klingspor, L.; Bouges-Michel, Claire; Poilane, Isabelle; Bougnoux, Marie Elisabeth; Dunand, Jean; Galeazzi, Guy; Bretagne, Stéphane; Fauchet, Nathalie; Forget, Elisabeth; Botterel, Françoise; Bonnal, Christine; Eloy, Odile; Lawrence, Christine; David, Marie Françoise; Mihaila, Liliana; Chachaty, Elisabeth; Adam, Olivier; Chochillon, Christian; Paugam, André; Baixench, Marie Thérèse; Cornet, Muriel; Escande, Marie Christine; Challier, Svetlana; Dannaoui, Eric; Datry, Annick; Laklache, Houria; Lminmouni, Bader; Brun, Sophie; Poirot, Jean Louis; Lacroix, Claire; Moissenet, Didier; Develoux, Michel; Bonacorsi, Stéphane; Tortorano, Anna Maria; Dho, Giovanna; Prigitano, Anna; Grancini, Anna; Ossi, Cristina; Giuliani, Giuseppe; Tejada, Milvana; Vismara, Chiara; Viola, Giovanna; Cavanna, Caterina; Passera, Marco; Farina, Claudio; Grossi, Antonio; Pinsi, Gabriele; Ceraminiello, Antonio; Casella, Pietro; Agrappi, Carlo; Sturla, Carla; Lombardi, Gianluigi; LoCascio, Giuliana; Deiana, Maria Luisa; Garau, Maria Graziella; Klingspor, Lean; Weigel, Andrea; Graf, Barbara; Ruhnke, Markus; Peman, Javier; Salonen, Juha H.; Meurman, Olli; Sarkkinen, Hannu; Sabino, Raquel; Videira, Zélia; Kirschner, Harald; Lass-Flörl, Cornelia; Maass, Matthias; Watschinger, Regina; Willinger, Birgit; Zeitlberger, Eva Maria; Velegraki, Aristea; Antonopoulou, Stavroula; Dimopoulos, George; Kouskouni, Evangelia; Petinaki, Efthimia; Trikka-Graphakos, Eleftheria; Vyzantiadis, A. Timoleon; Zerva, Loukia.
In: Journal of Clinical Microbiology, Vol. 49, No. 9, 09.2011, p. 3250-3256.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased mortality in young candidemia patients associated with presence of a Candida albicans general-purpose genotype
AU - Schmid, J.
AU - Tortorano, A. M.
AU - Jones, G.
AU - Lazzarini, C.
AU - Zhang, N.
AU - Bendall, M. J.
AU - Cogliati, M.
AU - Wattimena, S.
AU - Klingspor, L.
AU - Bouges-Michel, Claire
AU - Poilane, Isabelle
AU - Bougnoux, Marie Elisabeth
AU - Dunand, Jean
AU - Galeazzi, Guy
AU - Bretagne, Stéphane
AU - Fauchet, Nathalie
AU - Forget, Elisabeth
AU - Botterel, Françoise
AU - Bonnal, Christine
AU - Eloy, Odile
AU - Lawrence, Christine
AU - David, Marie Françoise
AU - Mihaila, Liliana
AU - Chachaty, Elisabeth
AU - Adam, Olivier
AU - Chochillon, Christian
AU - Paugam, André
AU - Baixench, Marie Thérèse
AU - Cornet, Muriel
AU - Escande, Marie Christine
AU - Challier, Svetlana
AU - Dannaoui, Eric
AU - Datry, Annick
AU - Laklache, Houria
AU - Lminmouni, Bader
AU - Brun, Sophie
AU - Poirot, Jean Louis
AU - Lacroix, Claire
AU - Moissenet, Didier
AU - Develoux, Michel
AU - Bonacorsi, Stéphane
AU - Tortorano, Anna Maria
AU - Dho, Giovanna
AU - Prigitano, Anna
AU - Grancini, Anna
AU - Ossi, Cristina
AU - Giuliani, Giuseppe
AU - Tejada, Milvana
AU - Vismara, Chiara
AU - Viola, Giovanna
AU - Cavanna, Caterina
AU - Passera, Marco
AU - Farina, Claudio
AU - Grossi, Antonio
AU - Pinsi, Gabriele
AU - Ceraminiello, Antonio
AU - Casella, Pietro
AU - Agrappi, Carlo
AU - Sturla, Carla
AU - Lombardi, Gianluigi
AU - LoCascio, Giuliana
AU - Deiana, Maria Luisa
AU - Garau, Maria Graziella
AU - Klingspor, Lean
AU - Weigel, Andrea
AU - Graf, Barbara
AU - Ruhnke, Markus
AU - Peman, Javier
AU - Salonen, Juha H.
AU - Meurman, Olli
AU - Sarkkinen, Hannu
AU - Sabino, Raquel
AU - Videira, Zélia
AU - Kirschner, Harald
AU - Lass-Flörl, Cornelia
AU - Maass, Matthias
AU - Watschinger, Regina
AU - Willinger, Birgit
AU - Zeitlberger, Eva Maria
AU - Velegraki, Aristea
AU - Antonopoulou, Stavroula
AU - Dimopoulos, George
AU - Kouskouni, Evangelia
AU - Petinaki, Efthimia
AU - Trikka-Graphakos, Eleftheria
AU - Vyzantiadis, A. Timoleon
AU - Zerva, Loukia
PY - 2011/9
Y1 - 2011/9
N2 - The yeast Candida albicans causes life-threatening candidemia. A general-purpose genotype (GPG; corresponds to clade 1) causes more infections than other C. albicans genotypes. To investigate if GPG strains also cause higher mortality, we developed a duplex PCR assay which was 98% accurate in identifying GPG strains in an international collection of strains typed with probe Ca3. We applied the assay to 635 European C. albicans candidemia isolates. Of these, 18% conformed to the GPG genotype, 4% were of a borderline genotype, and 78% were of a non-GPG genotype, broadly consistent with genotype distributions in earlier studies. The prevalence of GPG strains was increased in females and in younger patients, exceeding 40% in infants aged
AB - The yeast Candida albicans causes life-threatening candidemia. A general-purpose genotype (GPG; corresponds to clade 1) causes more infections than other C. albicans genotypes. To investigate if GPG strains also cause higher mortality, we developed a duplex PCR assay which was 98% accurate in identifying GPG strains in an international collection of strains typed with probe Ca3. We applied the assay to 635 European C. albicans candidemia isolates. Of these, 18% conformed to the GPG genotype, 4% were of a borderline genotype, and 78% were of a non-GPG genotype, broadly consistent with genotype distributions in earlier studies. The prevalence of GPG strains was increased in females and in younger patients, exceeding 40% in infants aged
UR - http://www.scopus.com/inward/record.url?scp=80052218564&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=80052218564&partnerID=8YFLogxK
U2 - 10.1128/JCM.00941-11
DO - 10.1128/JCM.00941-11
M3 - Article
C2 - 21775553
AN - SCOPUS:80052218564
VL - 49
SP - 3250
EP - 3256
JO - Journal of Clinical Microbiology
JF - Journal of Clinical Microbiology
SN - 0095-1137
IS - 9
ER -