Increased mortality in young candidemia patients associated with presence of a Candida albicans general-purpose genotype

J. Schmid, A. M. Tortorano, G. Jones, C. Lazzarini, N. Zhang, M. J. Bendall, M. Cogliati, S. Wattimena, L. Klingspor, Claire Bouges-Michel, Isabelle Poilane, Marie Elisabeth Bougnoux, Jean Dunand, Guy Galeazzi, Stéphane Bretagne, Nathalie Fauchet, Elisabeth Forget, Françoise Botterel, Christine Bonnal, Odile EloyChristine Lawrence, Marie Françoise David, Liliana Mihaila, Elisabeth Chachaty, Olivier Adam, Christian Chochillon, André Paugam, Marie Thérèse Baixench, Muriel Cornet, Marie Christine Escande, Svetlana Challier, Eric Dannaoui, Annick Datry, Houria Laklache, Bader Lminmouni, Sophie Brun, Jean Louis Poirot, Claire Lacroix, Didier Moissenet, Michel Develoux, Stéphane Bonacorsi, Anna Maria Tortorano, Giovanna Dho, Anna Prigitano, Anna Grancini, Cristina Ossi, Giuseppe Giuliani, Milvana Tejada, Chiara Vismara, Giovanna Viola, Caterina Cavanna, Marco Passera, Claudio Farina, Antonio Grossi, Gabriele Pinsi, Antonio Ceraminiello, Pietro Casella, Carlo Agrappi, Carla Sturla, Gianluigi Lombardi, Giuliana LoCascio, Maria Luisa Deiana, Maria Graziella Garau, Lean Klingspor, Andrea Weigel, Barbara Graf, Markus Ruhnke, Javier Peman, Juha H. Salonen, Olli Meurman, Hannu Sarkkinen, Raquel Sabino, Zélia Videira, Harald Kirschner, Cornelia Lass-Flörl, Matthias Maass, Regina Watschinger, Birgit Willinger, Eva Maria Zeitlberger, Aristea Velegraki, Stavroula Antonopoulou, George Dimopoulos, Evangelia Kouskouni, Efthimia Petinaki, Eleftheria Trikka-Graphakos, A. Timoleon Vyzantiadis, Loukia Zerva

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

The yeast Candida albicans causes life-threatening candidemia. A general-purpose genotype (GPG; corresponds to clade 1) causes more infections than other C. albicans genotypes. To investigate if GPG strains also cause higher mortality, we developed a duplex PCR assay which was 98% accurate in identifying GPG strains in an international collection of strains typed with probe Ca3. We applied the assay to 635 European C. albicans candidemia isolates. Of these, 18% conformed to the GPG genotype, 4% were of a borderline genotype, and 78% were of a non-GPG genotype, broadly consistent with genotype distributions in earlier studies. The prevalence of GPG strains was increased in females and in younger patients, exceeding 40% in infants aged

Original languageEnglish
Pages (from-to)3250-3256
Number of pages7
JournalJournal of Clinical Microbiology
Volume49
Issue number9
DOIs
Publication statusPublished - Sep 2011

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Candidemia
Candida albicans
Genotype
Mortality
Yeasts
Polymerase Chain Reaction
Infection

ASJC Scopus subject areas

  • Microbiology (medical)

Cite this

Schmid, J., Tortorano, A. M., Jones, G., Lazzarini, C., Zhang, N., Bendall, M. J., ... Zerva, L. (2011). Increased mortality in young candidemia patients associated with presence of a Candida albicans general-purpose genotype. Journal of Clinical Microbiology, 49(9), 3250-3256. https://doi.org/10.1128/JCM.00941-11

Increased mortality in young candidemia patients associated with presence of a Candida albicans general-purpose genotype. / Schmid, J.; Tortorano, A. M.; Jones, G.; Lazzarini, C.; Zhang, N.; Bendall, M. J.; Cogliati, M.; Wattimena, S.; Klingspor, L.; Bouges-Michel, Claire; Poilane, Isabelle; Bougnoux, Marie Elisabeth; Dunand, Jean; Galeazzi, Guy; Bretagne, Stéphane; Fauchet, Nathalie; Forget, Elisabeth; Botterel, Françoise; Bonnal, Christine; Eloy, Odile; Lawrence, Christine; David, Marie Françoise; Mihaila, Liliana; Chachaty, Elisabeth; Adam, Olivier; Chochillon, Christian; Paugam, André; Baixench, Marie Thérèse; Cornet, Muriel; Escande, Marie Christine; Challier, Svetlana; Dannaoui, Eric; Datry, Annick; Laklache, Houria; Lminmouni, Bader; Brun, Sophie; Poirot, Jean Louis; Lacroix, Claire; Moissenet, Didier; Develoux, Michel; Bonacorsi, Stéphane; Tortorano, Anna Maria; Dho, Giovanna; Prigitano, Anna; Grancini, Anna; Ossi, Cristina; Giuliani, Giuseppe; Tejada, Milvana; Vismara, Chiara; Viola, Giovanna; Cavanna, Caterina; Passera, Marco; Farina, Claudio; Grossi, Antonio; Pinsi, Gabriele; Ceraminiello, Antonio; Casella, Pietro; Agrappi, Carlo; Sturla, Carla; Lombardi, Gianluigi; LoCascio, Giuliana; Deiana, Maria Luisa; Garau, Maria Graziella; Klingspor, Lean; Weigel, Andrea; Graf, Barbara; Ruhnke, Markus; Peman, Javier; Salonen, Juha H.; Meurman, Olli; Sarkkinen, Hannu; Sabino, Raquel; Videira, Zélia; Kirschner, Harald; Lass-Flörl, Cornelia; Maass, Matthias; Watschinger, Regina; Willinger, Birgit; Zeitlberger, Eva Maria; Velegraki, Aristea; Antonopoulou, Stavroula; Dimopoulos, George; Kouskouni, Evangelia; Petinaki, Efthimia; Trikka-Graphakos, Eleftheria; Vyzantiadis, A. Timoleon; Zerva, Loukia.

In: Journal of Clinical Microbiology, Vol. 49, No. 9, 09.2011, p. 3250-3256.

Research output: Contribution to journalArticle

Schmid, J, Tortorano, AM, Jones, G, Lazzarini, C, Zhang, N, Bendall, MJ, Cogliati, M, Wattimena, S, Klingspor, L, Bouges-Michel, C, Poilane, I, Bougnoux, ME, Dunand, J, Galeazzi, G, Bretagne, S, Fauchet, N, Forget, E, Botterel, F, Bonnal, C, Eloy, O, Lawrence, C, David, MF, Mihaila, L, Chachaty, E, Adam, O, Chochillon, C, Paugam, A, Baixench, MT, Cornet, M, Escande, MC, Challier, S, Dannaoui, E, Datry, A, Laklache, H, Lminmouni, B, Brun, S, Poirot, JL, Lacroix, C, Moissenet, D, Develoux, M, Bonacorsi, S, Tortorano, AM, Dho, G, Prigitano, A, Grancini, A, Ossi, C, Giuliani, G, Tejada, M, Vismara, C, Viola, G, Cavanna, C, Passera, M, Farina, C, Grossi, A, Pinsi, G, Ceraminiello, A, Casella, P, Agrappi, C, Sturla, C, Lombardi, G, LoCascio, G, Deiana, ML, Garau, MG, Klingspor, L, Weigel, A, Graf, B, Ruhnke, M, Peman, J, Salonen, JH, Meurman, O, Sarkkinen, H, Sabino, R, Videira, Z, Kirschner, H, Lass-Flörl, C, Maass, M, Watschinger, R, Willinger, B, Zeitlberger, EM, Velegraki, A, Antonopoulou, S, Dimopoulos, G, Kouskouni, E, Petinaki, E, Trikka-Graphakos, E, Vyzantiadis, AT & Zerva, L 2011, 'Increased mortality in young candidemia patients associated with presence of a Candida albicans general-purpose genotype', Journal of Clinical Microbiology, vol. 49, no. 9, pp. 3250-3256. https://doi.org/10.1128/JCM.00941-11
Schmid, J. ; Tortorano, A. M. ; Jones, G. ; Lazzarini, C. ; Zhang, N. ; Bendall, M. J. ; Cogliati, M. ; Wattimena, S. ; Klingspor, L. ; Bouges-Michel, Claire ; Poilane, Isabelle ; Bougnoux, Marie Elisabeth ; Dunand, Jean ; Galeazzi, Guy ; Bretagne, Stéphane ; Fauchet, Nathalie ; Forget, Elisabeth ; Botterel, Françoise ; Bonnal, Christine ; Eloy, Odile ; Lawrence, Christine ; David, Marie Françoise ; Mihaila, Liliana ; Chachaty, Elisabeth ; Adam, Olivier ; Chochillon, Christian ; Paugam, André ; Baixench, Marie Thérèse ; Cornet, Muriel ; Escande, Marie Christine ; Challier, Svetlana ; Dannaoui, Eric ; Datry, Annick ; Laklache, Houria ; Lminmouni, Bader ; Brun, Sophie ; Poirot, Jean Louis ; Lacroix, Claire ; Moissenet, Didier ; Develoux, Michel ; Bonacorsi, Stéphane ; Tortorano, Anna Maria ; Dho, Giovanna ; Prigitano, Anna ; Grancini, Anna ; Ossi, Cristina ; Giuliani, Giuseppe ; Tejada, Milvana ; Vismara, Chiara ; Viola, Giovanna ; Cavanna, Caterina ; Passera, Marco ; Farina, Claudio ; Grossi, Antonio ; Pinsi, Gabriele ; Ceraminiello, Antonio ; Casella, Pietro ; Agrappi, Carlo ; Sturla, Carla ; Lombardi, Gianluigi ; LoCascio, Giuliana ; Deiana, Maria Luisa ; Garau, Maria Graziella ; Klingspor, Lean ; Weigel, Andrea ; Graf, Barbara ; Ruhnke, Markus ; Peman, Javier ; Salonen, Juha H. ; Meurman, Olli ; Sarkkinen, Hannu ; Sabino, Raquel ; Videira, Zélia ; Kirschner, Harald ; Lass-Flörl, Cornelia ; Maass, Matthias ; Watschinger, Regina ; Willinger, Birgit ; Zeitlberger, Eva Maria ; Velegraki, Aristea ; Antonopoulou, Stavroula ; Dimopoulos, George ; Kouskouni, Evangelia ; Petinaki, Efthimia ; Trikka-Graphakos, Eleftheria ; Vyzantiadis, A. Timoleon ; Zerva, Loukia. / Increased mortality in young candidemia patients associated with presence of a Candida albicans general-purpose genotype. In: Journal of Clinical Microbiology. 2011 ; Vol. 49, No. 9. pp. 3250-3256.
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abstract = "The yeast Candida albicans causes life-threatening candidemia. A general-purpose genotype (GPG; corresponds to clade 1) causes more infections than other C. albicans genotypes. To investigate if GPG strains also cause higher mortality, we developed a duplex PCR assay which was 98{\%} accurate in identifying GPG strains in an international collection of strains typed with probe Ca3. We applied the assay to 635 European C. albicans candidemia isolates. Of these, 18{\%} conformed to the GPG genotype, 4{\%} were of a borderline genotype, and 78{\%} were of a non-GPG genotype, broadly consistent with genotype distributions in earlier studies. The prevalence of GPG strains was increased in females and in younger patients, exceeding 40{\%} in infants aged",
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AU - Schmid, J.

AU - Tortorano, A. M.

AU - Jones, G.

AU - Lazzarini, C.

AU - Zhang, N.

AU - Bendall, M. J.

AU - Cogliati, M.

AU - Wattimena, S.

AU - Klingspor, L.

AU - Bouges-Michel, Claire

AU - Poilane, Isabelle

AU - Bougnoux, Marie Elisabeth

AU - Dunand, Jean

AU - Galeazzi, Guy

AU - Bretagne, Stéphane

AU - Fauchet, Nathalie

AU - Forget, Elisabeth

AU - Botterel, Françoise

AU - Bonnal, Christine

AU - Eloy, Odile

AU - Lawrence, Christine

AU - David, Marie Françoise

AU - Mihaila, Liliana

AU - Chachaty, Elisabeth

AU - Adam, Olivier

AU - Chochillon, Christian

AU - Paugam, André

AU - Baixench, Marie Thérèse

AU - Cornet, Muriel

AU - Escande, Marie Christine

AU - Challier, Svetlana

AU - Dannaoui, Eric

AU - Datry, Annick

AU - Laklache, Houria

AU - Lminmouni, Bader

AU - Brun, Sophie

AU - Poirot, Jean Louis

AU - Lacroix, Claire

AU - Moissenet, Didier

AU - Develoux, Michel

AU - Bonacorsi, Stéphane

AU - Tortorano, Anna Maria

AU - Dho, Giovanna

AU - Prigitano, Anna

AU - Grancini, Anna

AU - Ossi, Cristina

AU - Giuliani, Giuseppe

AU - Tejada, Milvana

AU - Vismara, Chiara

AU - Viola, Giovanna

AU - Cavanna, Caterina

AU - Passera, Marco

AU - Farina, Claudio

AU - Grossi, Antonio

AU - Pinsi, Gabriele

AU - Ceraminiello, Antonio

AU - Casella, Pietro

AU - Agrappi, Carlo

AU - Sturla, Carla

AU - Lombardi, Gianluigi

AU - LoCascio, Giuliana

AU - Deiana, Maria Luisa

AU - Garau, Maria Graziella

AU - Klingspor, Lean

AU - Weigel, Andrea

AU - Graf, Barbara

AU - Ruhnke, Markus

AU - Peman, Javier

AU - Salonen, Juha H.

AU - Meurman, Olli

AU - Sarkkinen, Hannu

AU - Sabino, Raquel

AU - Videira, Zélia

AU - Kirschner, Harald

AU - Lass-Flörl, Cornelia

AU - Maass, Matthias

AU - Watschinger, Regina

AU - Willinger, Birgit

AU - Zeitlberger, Eva Maria

AU - Velegraki, Aristea

AU - Antonopoulou, Stavroula

AU - Dimopoulos, George

AU - Kouskouni, Evangelia

AU - Petinaki, Efthimia

AU - Trikka-Graphakos, Eleftheria

AU - Vyzantiadis, A. Timoleon

AU - Zerva, Loukia

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