Increased motor response to cocaine administration following recovery from chronic corticosterone treatment in the rat

Francesca R. Patacchioli, Francesco E. Pontieri, Francesco Orzi, Renato Di Grezia, Luciano Angelucci

Research output: Contribution to journalArticle

Abstract

Several lines of evidence suggest interaction between glucocorticoids and the rat brain dopaminergic system. Here we demonstrate that a two week recovery from chronic high-dose corticosterone treatment potentiates the behavioral response to acute cocaine challenge in the rat. This effect is associated with significant increases of plasma corticosterone levels in response to cocaine. Then, derangement of the hypothalamus-pituitary-adrenal axis, induced by long-term treatment with corticosterone, facilitates the behavioral response to cocaine.

Original languageEnglish
Pages (from-to)43-46
Number of pages4
JournalEuropean Neuropsychopharmacology
Volume8
Issue number1
DOIs
Publication statusPublished - Feb 1 1998

Keywords

  • Cocaine
  • Corticosterone
  • Locomotor activity
  • Rat

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Biological Psychiatry
  • Neurology
  • Pharmacology
  • Psychology(all)

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