Increased nitric oxide in exhaled air of patients with systemic lupus erythematosus

Giovanni Rolla, Luisa Brussino, Maria Tiziana Bertero, Paola Colagrande, Marcella Converso, Caterina Bucca, Salvatore Polizzi, Federico Caligaris-Cappio

Research output: Contribution to journalArticle

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Abstract

Objective. In experimental animals, elevated nitric oxide (NO) production has been implicated in the pathogenesis of a lupus-like syndrome. Abnormalities of lung function tests are reported in a high proportion of patients with systemic lupus erythematosus (SLE). We investigated whether NO output in exhaled air might be increased in patients with SLE and whether it is related to disease activity and to respiratory function abnormalities. Methods. Lung volume, maximal expiratory flow at 50 and 25% of vital capacity (MEF 50 and MEF 25), diffusion coefficient for carbon monoxide (K(CO)), and NO in the exhaled air were measured in 27 outpatients with SLE (23 women, age 39.2 ± 16.3). NO in exhaled air was also measured in 30 healthy control subjects. Disease activity was assessed by the European Consensus Lupus Activity Measurement (ECLAM) scoring system. Results. Mean values of peak concentrations of NO exhaled air were 64.8 ± 27.9 parts per billion (ppb) in patients and 31.6 ± 7.7 ppb in controls, p <0.001. Peak NO concentration was directly related to ECLAM activity score (p <0.05) and inversely related to MEF 25 (p <0.05). Conclusion. NO in exhaled air is significantly increased and correlated with disease activity in patients with SLE. Whether increased NO output depends on respiratory tract inflammation, as the relationship with MEF 25 may suggest, or on circulating cytokines produced elsewhere remains to be investigated.

Original languageEnglish
Pages (from-to)1066-1071
Number of pages6
JournalJournal of Rheumatology
Volume24
Issue number6
Publication statusPublished - Jun 1997

Fingerprint

Systemic Lupus Erythematosus
Nitric Oxide
Air
Carbon Monoxide
Respiratory Function Tests
Vital Capacity
Respiratory System
Healthy Volunteers
Outpatients
Cytokines
Inflammation
Lung

Keywords

  • Nitric oxide
  • Pulmonary function tests
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

Rolla, G., Brussino, L., Bertero, M. T., Colagrande, P., Converso, M., Bucca, C., ... Caligaris-Cappio, F. (1997). Increased nitric oxide in exhaled air of patients with systemic lupus erythematosus. Journal of Rheumatology, 24(6), 1066-1071.

Increased nitric oxide in exhaled air of patients with systemic lupus erythematosus. / Rolla, Giovanni; Brussino, Luisa; Bertero, Maria Tiziana; Colagrande, Paola; Converso, Marcella; Bucca, Caterina; Polizzi, Salvatore; Caligaris-Cappio, Federico.

In: Journal of Rheumatology, Vol. 24, No. 6, 06.1997, p. 1066-1071.

Research output: Contribution to journalArticle

Rolla, G, Brussino, L, Bertero, MT, Colagrande, P, Converso, M, Bucca, C, Polizzi, S & Caligaris-Cappio, F 1997, 'Increased nitric oxide in exhaled air of patients with systemic lupus erythematosus', Journal of Rheumatology, vol. 24, no. 6, pp. 1066-1071.
Rolla G, Brussino L, Bertero MT, Colagrande P, Converso M, Bucca C et al. Increased nitric oxide in exhaled air of patients with systemic lupus erythematosus. Journal of Rheumatology. 1997 Jun;24(6):1066-1071.
Rolla, Giovanni ; Brussino, Luisa ; Bertero, Maria Tiziana ; Colagrande, Paola ; Converso, Marcella ; Bucca, Caterina ; Polizzi, Salvatore ; Caligaris-Cappio, Federico. / Increased nitric oxide in exhaled air of patients with systemic lupus erythematosus. In: Journal of Rheumatology. 1997 ; Vol. 24, No. 6. pp. 1066-1071.
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abstract = "Objective. In experimental animals, elevated nitric oxide (NO) production has been implicated in the pathogenesis of a lupus-like syndrome. Abnormalities of lung function tests are reported in a high proportion of patients with systemic lupus erythematosus (SLE). We investigated whether NO output in exhaled air might be increased in patients with SLE and whether it is related to disease activity and to respiratory function abnormalities. Methods. Lung volume, maximal expiratory flow at 50 and 25{\%} of vital capacity (MEF 50 and MEF 25), diffusion coefficient for carbon monoxide (K(CO)), and NO in the exhaled air were measured in 27 outpatients with SLE (23 women, age 39.2 ± 16.3). NO in exhaled air was also measured in 30 healthy control subjects. Disease activity was assessed by the European Consensus Lupus Activity Measurement (ECLAM) scoring system. Results. Mean values of peak concentrations of NO exhaled air were 64.8 ± 27.9 parts per billion (ppb) in patients and 31.6 ± 7.7 ppb in controls, p <0.001. Peak NO concentration was directly related to ECLAM activity score (p <0.05) and inversely related to MEF 25 (p <0.05). Conclusion. NO in exhaled air is significantly increased and correlated with disease activity in patients with SLE. Whether increased NO output depends on respiratory tract inflammation, as the relationship with MEF 25 may suggest, or on circulating cytokines produced elsewhere remains to be investigated.",
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AU - Converso, Marcella

AU - Bucca, Caterina

AU - Polizzi, Salvatore

AU - Caligaris-Cappio, Federico

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AB - Objective. In experimental animals, elevated nitric oxide (NO) production has been implicated in the pathogenesis of a lupus-like syndrome. Abnormalities of lung function tests are reported in a high proportion of patients with systemic lupus erythematosus (SLE). We investigated whether NO output in exhaled air might be increased in patients with SLE and whether it is related to disease activity and to respiratory function abnormalities. Methods. Lung volume, maximal expiratory flow at 50 and 25% of vital capacity (MEF 50 and MEF 25), diffusion coefficient for carbon monoxide (K(CO)), and NO in the exhaled air were measured in 27 outpatients with SLE (23 women, age 39.2 ± 16.3). NO in exhaled air was also measured in 30 healthy control subjects. Disease activity was assessed by the European Consensus Lupus Activity Measurement (ECLAM) scoring system. Results. Mean values of peak concentrations of NO exhaled air were 64.8 ± 27.9 parts per billion (ppb) in patients and 31.6 ± 7.7 ppb in controls, p <0.001. Peak NO concentration was directly related to ECLAM activity score (p <0.05) and inversely related to MEF 25 (p <0.05). Conclusion. NO in exhaled air is significantly increased and correlated with disease activity in patients with SLE. Whether increased NO output depends on respiratory tract inflammation, as the relationship with MEF 25 may suggest, or on circulating cytokines produced elsewhere remains to be investigated.

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