Increased nocturnal heart rate andwave reflection are earlymarkers of cardiovascular disease in Williams-Beuren syndrome children

Alessandro Maloberti, Francesca Cesana, Bernhard Hametner, Dario Dozio, Paolo Villa, Martin Hulpke-Wette, Achim Schwarz, Angelo Selicorni, Siegfried Wassertheurer, Giuseppe Mancia, Cristina Giannattasio

Research output: Contribution to journalArticle

Abstract

Objective: Williams-Beuren syndrome (WBS) is a genetic disorder that involves elastin gene causing cardiovascular abnormalities and increased risk. However, data on arterial function in these patients are only few and conflicting. Aim of this study was to evaluate dynamic behaviour of central and peripheral blood pressure (BP) and arterial stiffness parameters early in the course of WBS. Methods: We enrolled 19 WBS paediatric patients (age 13-4 years) and 23 age, height and BP-matched controls (10±4 years). We evaluated 24-h ambulatory BP values via an ambulatory blood pressure monitoring (ABPM) system (Mobil-O-Graph) also capable to calculate 24-h central BP and 24-h arterial stiffness parameters. Carotid-femoral PWV (cf-PWV) was assessed in all WBS individuals (Complior). Results: BP values were similar in WBS and control, during the daytime and the night-time. The same behaviour applies to 24-h central BP. However, during the night, WBS showed heart rate values (HR; 78-10 vs. 71-9 bpm; P

Original languageEnglish
Pages (from-to)804-809
Number of pages6
JournalJournal of Hypertension
Volume33
Issue number4
DOIs
Publication statusPublished - Apr 1 2015

Keywords

  • Ambulatory blood pressure monitoring
  • Elastin
  • Pulse wave velocity
  • Vascular stiffness
  • Williams-Beuren syndrome

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Fingerprint Dive into the research topics of 'Increased nocturnal heart rate andwave reflection are earlymarkers of cardiovascular disease in Williams-Beuren syndrome children'. Together they form a unique fingerprint.

  • Cite this

    Maloberti, A., Cesana, F., Hametner, B., Dozio, D., Villa, P., Hulpke-Wette, M., Schwarz, A., Selicorni, A., Wassertheurer, S., Mancia, G., & Giannattasio, C. (2015). Increased nocturnal heart rate andwave reflection are earlymarkers of cardiovascular disease in Williams-Beuren syndrome children. Journal of Hypertension, 33(4), 804-809. https://doi.org/10.1097/HJH.0000000000000454