Increased number of brain benzodiazepine receptors after in-vivo administration of estazolam to rats

T. Mennini, M. Gobbi, S. Garattini

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Estazolam significantly increaed the K(d) of [3H]flunitrazepam in-vitro, like other benzodiazepines (BDZs) acting competitively at the receptor site. At variance with other BDZs, estazolam significantly raised the B(max) for [3H]flunitrazepam, at concentrations lower than its K(i) for BDZ receptors. This effect may be responsible for the observed increase in [3H]diazepam binding after in-vivo administration of estazolam to rats.

Original languageEnglish
Pages (from-to)621-622
Number of pages2
JournalJournal of Pharmacy and Pharmacology
Volume36
Issue number9
Publication statusPublished - 1984

Fingerprint

Estazolam
GABA-A Receptors
Flunitrazepam
Benzodiazepines
Brain
Diazepam

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

Cite this

@article{2fd2a04a30764c37a662dc71a95e93d4,
title = "Increased number of brain benzodiazepine receptors after in-vivo administration of estazolam to rats",
abstract = "Estazolam significantly increaed the K(d) of [3H]flunitrazepam in-vitro, like other benzodiazepines (BDZs) acting competitively at the receptor site. At variance with other BDZs, estazolam significantly raised the B(max) for [3H]flunitrazepam, at concentrations lower than its K(i) for BDZ receptors. This effect may be responsible for the observed increase in [3H]diazepam binding after in-vivo administration of estazolam to rats.",
author = "T. Mennini and M. Gobbi and S. Garattini",
year = "1984",
language = "English",
volume = "36",
pages = "621--622",
journal = "Journal of Pharmacy and Pharmacology",
issn = "0022-3573",
publisher = "Pharmaceutical Press",
number = "9",

}

TY - JOUR

T1 - Increased number of brain benzodiazepine receptors after in-vivo administration of estazolam to rats

AU - Mennini, T.

AU - Gobbi, M.

AU - Garattini, S.

PY - 1984

Y1 - 1984

N2 - Estazolam significantly increaed the K(d) of [3H]flunitrazepam in-vitro, like other benzodiazepines (BDZs) acting competitively at the receptor site. At variance with other BDZs, estazolam significantly raised the B(max) for [3H]flunitrazepam, at concentrations lower than its K(i) for BDZ receptors. This effect may be responsible for the observed increase in [3H]diazepam binding after in-vivo administration of estazolam to rats.

AB - Estazolam significantly increaed the K(d) of [3H]flunitrazepam in-vitro, like other benzodiazepines (BDZs) acting competitively at the receptor site. At variance with other BDZs, estazolam significantly raised the B(max) for [3H]flunitrazepam, at concentrations lower than its K(i) for BDZ receptors. This effect may be responsible for the observed increase in [3H]diazepam binding after in-vivo administration of estazolam to rats.

UR - http://www.scopus.com/inward/record.url?scp=0021139566&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021139566&partnerID=8YFLogxK

M3 - Article

VL - 36

SP - 621

EP - 622

JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

SN - 0022-3573

IS - 9

ER -