Increased number of brain benzodiazepine receptors after in-vivo administration of estazolam to rats

T. Mennini, M. Gobbi, S. Garattini

Research output: Contribution to journalArticle

Abstract

Estazolam significantly increaed the K(d) of [3H]flunitrazepam in-vitro, like other benzodiazepines (BDZs) acting competitively at the receptor site. At variance with other BDZs, estazolam significantly raised the B(max) for [3H]flunitrazepam, at concentrations lower than its K(i) for BDZ receptors. This effect may be responsible for the observed increase in [3H]diazepam binding after in-vivo administration of estazolam to rats.

Original languageEnglish
Pages (from-to)621-622
Number of pages2
JournalJournal of Pharmacy and Pharmacology
Volume36
Issue number9
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Pharmacology

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