Increased number of caveolae and caveolin-3 overexpression in Duchenne muscular dystrophy

Silvia Repetto, Massimo Bado, Paolo Broda, Giuseppe Lucania, Emiliana Masetti, Federica Sotgia, Ilaria Carbone, Antonio Pavan, Eduardo Bonilla, Giuseppe Cordone, Michael P. Lisanti, Carlo Minetti

Research output: Contribution to journalArticlepeer-review

Abstract

Caveolae are small pockets or invaginations localized at the plasma membrane. Caveolins are the principal protein components of caveolae and play an important structural role in the formation of caveolae membranes. Here, we studied by freeze fracture and immunological techniques the spatial organization of caveolae at the muscle cell plasma membrane and the expression of caveolin-3 in Duchenne muscular dystrophy (DMD) muscle fibers. In DMD muscle, we found an increased number of caveolae at the sarcolemma that corresponds to an overexpression of caveolin-3 by immunohistochemistry and by Western blot analysis. These findings suggest a possible role for caveolae and caveolin-3 in the pathogenesis of DMD.

Original languageEnglish
Pages (from-to)547-550
Number of pages4
JournalBiochemical and Biophysical Research Communications
Volume261
Issue number3
DOIs
Publication statusPublished - Aug 11 1999

Keywords

  • Caveolae membranes
  • Caveolin-3
  • Duchenne muscular dystrophy

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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