Increased osteoclast activity is associated with aggressiveness of osteosarcoma

Sofia Avnet, Alessandra Longhi, Manuela Salerno, Jussi M. Halleen, Francesca Perut, Donatella Granchi, Stefano Ferrari, Franco Bertoni, Armando Giunti, Nicola Baldini

Research output: Contribution to journalArticlepeer-review

Abstract

Osteosarcoma (OS) is a highly malignant primary skeletal tumor with a striking tendency to rapidly destroy the surrounding bone and metastasize, since metastases are frequently present at clinical onset. The basis for the aggressiveness of this tumor is largely unknown. However, recent studies in in vivo models indicate that the anti-osteolytic drugs, bisphosphonates, can inhibit the tumor local expansion and the formation of metastases. We further investigated the association between the presence of active osteoclasts and the aggressiveness of OS. We evaluated the presence of osteoclasts and the mRNA of different osteoclast-related genes in tumor biopsies from 16 OS patients and in three OS cell lines and the serum levels of bone resorption markers in the same series and in 28 other patients. Tumor-associated osteoclasts were found in 63 and 75% of cases by histological and mRNA analysis. Among different serum markers, only MMP-9 was significantly higher in OS cases (p=0.0001), whereas TRACP 5b was significantly higher in metastatic patients compared to nonmetastatic patients (p=0.0509). Serum TRACP 5b was significantly correlated to serum NTX (p

Original languageEnglish
Pages (from-to)1231-1238
Number of pages8
JournalInternational Journal of Oncology
Volume33
Issue number6
DOIs
Publication statusPublished - 2008

Keywords

  • Bone turnover markers
  • Metastases
  • Osteoclast
  • Osteosarcoma
  • Tumor aggressiveness

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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