Increased perioperative N-terminal pro-B-type natriuretic peptide levels predict atrial fibrillation after thoracic surgery for lung cancer

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Abstract

BACKGROUND - Postoperative atrial fibrillation (AF) is a complication of thoracic surgery for lung cancer, with a reported incidence that can run as high as 42%. Recently, it has been observed retrospectively that B-type natriuretic peptide predicts AF after cardiac surgery. We performed a prospective study to evaluate the role of N-terminal pro-B-type natriuretic peptide (NT-proBNP) as a marker for risk stratification of postoperative AF in patients undergoing thoracic surgery for lung cancer. METHODS AND RESULTS - We measured NT-proBNP levels in 400 patients (mean age, 62±10 years; 271 men) 24 hours before and 1 hour after surgery. The primary end point of the study was the incidence of postoperative AF. Overall, postoperative AF occurred in 72 patients (18%). Eighty-eight patients (22%) showed an elevated perioperative NT-proBNP value. When patients with either preoperatively or postoperatively elevated NT-proBNP were pooled, a greater incidence of AF was observed compared with patients with normal values (64% versus 5%; P

Original languageEnglish
Pages (from-to)1339-1344
Number of pages6
JournalCirculation
Volume115
Issue number11
DOIs
Publication statusPublished - Mar 2007

Keywords

  • Atrial fibrillation
  • Natriuretic peptides
  • Thoracic surgery

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

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