TY - JOUR
T1 - Increased perioperative N-terminal pro-B-type natriuretic peptide levels predict atrial fibrillation after thoracic surgery for lung cancer
AU - Cardinale, Daniela
AU - Colombo, Alessandro
AU - Sandri, Maria T.
AU - Lamantia, Giuseppina
AU - Colombo, Nicola
AU - Civelli, Maurizio
AU - Salvatici, Michela
AU - Veronesi, Giulia
AU - Veglia, Fabrizio
AU - Fiorentini, Cesare
AU - Spaggiari, Lorenzo
AU - Cipolla, Carlo M.
PY - 2007/3
Y1 - 2007/3
N2 - BACKGROUND - Postoperative atrial fibrillation (AF) is a complication of thoracic surgery for lung cancer, with a reported incidence that can run as high as 42%. Recently, it has been observed retrospectively that B-type natriuretic peptide predicts AF after cardiac surgery. We performed a prospective study to evaluate the role of N-terminal pro-B-type natriuretic peptide (NT-proBNP) as a marker for risk stratification of postoperative AF in patients undergoing thoracic surgery for lung cancer. METHODS AND RESULTS - We measured NT-proBNP levels in 400 patients (mean age, 62±10 years; 271 men) 24 hours before and 1 hour after surgery. The primary end point of the study was the incidence of postoperative AF. Overall, postoperative AF occurred in 72 patients (18%). Eighty-eight patients (22%) showed an elevated perioperative NT-proBNP value. When patients with either preoperatively or postoperatively elevated NT-proBNP were pooled, a greater incidence of AF was observed compared with patients with normal values (64% versus 5%; P
AB - BACKGROUND - Postoperative atrial fibrillation (AF) is a complication of thoracic surgery for lung cancer, with a reported incidence that can run as high as 42%. Recently, it has been observed retrospectively that B-type natriuretic peptide predicts AF after cardiac surgery. We performed a prospective study to evaluate the role of N-terminal pro-B-type natriuretic peptide (NT-proBNP) as a marker for risk stratification of postoperative AF in patients undergoing thoracic surgery for lung cancer. METHODS AND RESULTS - We measured NT-proBNP levels in 400 patients (mean age, 62±10 years; 271 men) 24 hours before and 1 hour after surgery. The primary end point of the study was the incidence of postoperative AF. Overall, postoperative AF occurred in 72 patients (18%). Eighty-eight patients (22%) showed an elevated perioperative NT-proBNP value. When patients with either preoperatively or postoperatively elevated NT-proBNP were pooled, a greater incidence of AF was observed compared with patients with normal values (64% versus 5%; P
KW - Atrial fibrillation
KW - Natriuretic peptides
KW - Thoracic surgery
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U2 - 10.1161/CIRCULATIONAHA.106.647008
DO - 10.1161/CIRCULATIONAHA.106.647008
M3 - Article
C2 - 17339553
AN - SCOPUS:34147188584
VL - 115
SP - 1339
EP - 1344
JO - Circulation
JF - Circulation
SN - 0009-7322
IS - 11
ER -