Increased plasma concentrations of lipoprotein(a) for every phenotype of apolipoprotein(a) in patients with chronic renal failure treated by hemodialysis

C. Gazzaruso, G. Bonetti, A. Garzaniti, G. Pini, A. Ragazzoni, C. Bianchi, A. Jucci, P. Buscaglia, D. Geroldi

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background and Aims: Uremic patients on hemodialysis show high levels of lipoprotein(a) [Lp(a)]. Whereas in Japanese and Spanish hemodialysis patients high Lp(a) levels have been found for every apo(a) phenotype, in Austrian hemodialysis patients two studies showed an apo(a) phenotype- associated elevation of Lp(a) concentration. In this investigation we studied the influence of apo(a) genetic polymorphism on Lp(a) concentrations in a large group of Italian patients with chronic renal failure on hemodialysis. Methods and Results: Lp (a) levels were about three times higher in patients (n= 138) than in controls (n= 148): 27.7 mg/dl (2.5-131) vs 10.0 mg/dl (0-64.5); p

Original languageEnglish
Pages (from-to)203-210
Number of pages8
JournalNutrition, Metabolism and Cardiovascular Diseases
Volume6
Issue number4
Publication statusPublished - Dec 1996

Fingerprint

Apoprotein(a)
Lipoprotein(a)
apolipoproteins
hemodialysis
renal failure
lipoproteins
Chronic Kidney Failure
Renal Dialysis
Phenotype
phenotype
Genetic Polymorphisms
genetic polymorphism

Keywords

  • Apolipoprotein(a)
  • Chronic renal failure
  • Hemodialysis
  • Lipoprotein(a)

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Cardiology and Cardiovascular Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Increased plasma concentrations of lipoprotein(a) for every phenotype of apolipoprotein(a) in patients with chronic renal failure treated by hemodialysis. / Gazzaruso, C.; Bonetti, G.; Garzaniti, A.; Pini, G.; Ragazzoni, A.; Bianchi, C.; Jucci, A.; Buscaglia, P.; Geroldi, D.

In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 6, No. 4, 12.1996, p. 203-210.

Research output: Contribution to journalArticle

Gazzaruso, C. ; Bonetti, G. ; Garzaniti, A. ; Pini, G. ; Ragazzoni, A. ; Bianchi, C. ; Jucci, A. ; Buscaglia, P. ; Geroldi, D. / Increased plasma concentrations of lipoprotein(a) for every phenotype of apolipoprotein(a) in patients with chronic renal failure treated by hemodialysis. In: Nutrition, Metabolism and Cardiovascular Diseases. 1996 ; Vol. 6, No. 4. pp. 203-210.
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AU - Gazzaruso, C.

AU - Bonetti, G.

AU - Garzaniti, A.

AU - Pini, G.

AU - Ragazzoni, A.

AU - Bianchi, C.

AU - Jucci, A.

AU - Buscaglia, P.

AU - Geroldi, D.

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AB - Background and Aims: Uremic patients on hemodialysis show high levels of lipoprotein(a) [Lp(a)]. Whereas in Japanese and Spanish hemodialysis patients high Lp(a) levels have been found for every apo(a) phenotype, in Austrian hemodialysis patients two studies showed an apo(a) phenotype- associated elevation of Lp(a) concentration. In this investigation we studied the influence of apo(a) genetic polymorphism on Lp(a) concentrations in a large group of Italian patients with chronic renal failure on hemodialysis. Methods and Results: Lp (a) levels were about three times higher in patients (n= 138) than in controls (n= 148): 27.7 mg/dl (2.5-131) vs 10.0 mg/dl (0-64.5); p

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