Increased plasma corticosterone and decreased plasma thyroid stimulating hormone levels in rats treated with vincristine

L. Annunziato, G. F. Di Renzo, G. Schettini, U. Scapagnini, P. Preziosi

Research output: Contribution to journalArticle

Abstract

A single i.p. injection of vincristine (1000 μg/kg) into rats increased the plasma concentration of corticosterone after a latent period of 4 hr; the effect lasted for 48 hr. The response was dose related with the threshold dose being 100 μg/kg and the maximal effect occurring after 250 μg/kg. Vincristine also increased plasma corticosterone levels in hypophysectomized rats, suggesting that the drug may have a direct action on the adrenal gland. The injection of 500 or 1000 μg/kg also reduced the plasma concentration of thyroid-stimulating hormone. Twelve and 18 hr after the injection of vincristine (1000 μg/kg), the plasma concentration of thyroid-stimulating hormone was reduced, whereas the hypothalamic content of norepinephrine, a neurotransmitter involved in the regulation of thyrotropin-releasing hormone-thyroid-stimulating hormone secretion, remained unchanged. The adrenocortical stimulation produced by vincristine may play some role in the antineoplastic effects of this drug.

Original languageEnglish
JournalCancer Research
Volume37
Issue number8
Publication statusPublished - 1977

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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