Increased plasma levels of interleukin-1, interleukin-6 and α-1-antichymotrypsin in patients with Alzheimer's disease: Peripheral inflammation or signals from the brain?

Federico Licastro, Steve Pedrini, Ludovica Caputo, Giorgio Annoni, Lizabeth Jane Davis, Cinzia Ferri, Valeria Casadei, L. M E Grimaldi

Research output: Contribution to journalArticlepeer-review

Abstract

Plasma concentrations of interleukin-1β (IL-1β), interleukin-6 (IL-6), C reactive protein (CRP) and α-1-antichymotrypsin (ACT) in 145 patients with probable Alzheimer's disease (AD) and 51 non-demented controls were measured. To investigate the cellular activation of peripheral immune system, plasma levels of neopterin were also investigated. Plasma levels of IL-1 were detectable in 17 patients with AD (13%) and only in one control (2%) and average levels of IL-1 were higher in AD patients than in controls (p

Original languageEnglish
Pages (from-to)97-102
Number of pages6
JournalJournal of Neuroimmunology
Volume103
Issue number1
DOIs
Publication statusPublished - Feb 1 2000

Keywords

  • ACT
  • Alzheimer's disease
  • Cognitive impairment
  • IL-6
  • Plasma IL-1

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy
  • Clinical Neurology
  • Neurology

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