TY - JOUR
T1 - Increased plasma levels of interleukin-1, interleukin-6 and α-1-antichymotrypsin in patients with Alzheimer's disease
T2 - Peripheral inflammation or signals from the brain?
AU - Licastro, Federico
AU - Pedrini, Steve
AU - Caputo, Ludovica
AU - Annoni, Giorgio
AU - Davis, Lizabeth Jane
AU - Ferri, Cinzia
AU - Casadei, Valeria
AU - Grimaldi, L. M E
PY - 2000/2/1
Y1 - 2000/2/1
N2 - Plasma concentrations of interleukin-1β (IL-1β), interleukin-6 (IL-6), C reactive protein (CRP) and α-1-antichymotrypsin (ACT) in 145 patients with probable Alzheimer's disease (AD) and 51 non-demented controls were measured. To investigate the cellular activation of peripheral immune system, plasma levels of neopterin were also investigated. Plasma levels of IL-1 were detectable in 17 patients with AD (13%) and only in one control (2%) and average levels of IL-1 were higher in AD patients than in controls (p
AB - Plasma concentrations of interleukin-1β (IL-1β), interleukin-6 (IL-6), C reactive protein (CRP) and α-1-antichymotrypsin (ACT) in 145 patients with probable Alzheimer's disease (AD) and 51 non-demented controls were measured. To investigate the cellular activation of peripheral immune system, plasma levels of neopterin were also investigated. Plasma levels of IL-1 were detectable in 17 patients with AD (13%) and only in one control (2%) and average levels of IL-1 were higher in AD patients than in controls (p
KW - ACT
KW - Alzheimer's disease
KW - Cognitive impairment
KW - IL-6
KW - Plasma IL-1
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U2 - 10.1016/S0165-5728(99)00226-X
DO - 10.1016/S0165-5728(99)00226-X
M3 - Article
C2 - 10674995
AN - SCOPUS:0033966340
VL - 103
SP - 97
EP - 102
JO - Journal of Neuroimmunology
JF - Journal of Neuroimmunology
SN - 0165-5728
IS - 1
ER -