Increased plasma levels of platelet-derived growth factor activity in patients with progressive systemic sclerosis

A. Pandolfi, M. Florita, G. Altomare, P. Pigatto, M. B. Donati, A. Poggi

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We measured mitogenic activity of whole blood serum and platelet-poor plasma-derived serum of a group of 10 patients with progressive systemic sclerosis and of 8 controls. Mitogenic activity of plasma-derived serum was greater in patients than in controls, in the absence of other signs of platelet activation. This increased activity was inhibited by specific antibodies, anti-platelet derived growth factor, suggesting that circulating levels of platelet-derived growth factor may be present in progressive systemic sclerosis patients. Platelet-derived growth factor, released either by platelets or by monocytes, might play a role in the pathogenesis of scleroderma.

Original languageEnglish
Pages (from-to)1-4
Number of pages4
JournalProceedings of the Society for Experimental Biology and Medicine
Issue number1
Publication statusPublished - 1989


ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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