Increased plasma levels of platelet-derived growth factor (PDGF-BB + PDGF-AB) in patients with never-treated mild essential hypertension

Ermanno Rossi, Bruno Casali, Giuseppe Regolisti, Simona Davoli, Franco Perazzoli, Aurelio Negro, Carlo Sani, Bruno Tumiati, Davide Nicoli

Research output: Contribution to journalArticle

Abstract

Platelet-derived growth factor (PDGF) could play a role in both vascular hypertrophy and atherosclerotic disease associated with hypertension. To assess whether plasma PDGF level is increased in mild essential hypertension, we measured plasma PDGF concentration in 25 never-treated patients with uncomplicated mild essential hypertension and in 22 normotensive healthy subjects. To evaluate the contribution of platelets to plasma PDGF in the two groups, we also measured plasma β-thromboglobulin (BTG). Measurement of PDGF was carried out through an enzyme-linked immunoadsorbent assay, which detects two PDGF dimers, namely PDGF-BB and PDGF-AB. Both plasma PDGF and BTG were higher in the hypertensive than in the normotensive subjects. The ratio of PDGF to BTG was similar in the two groups. Plasma PDGF was weakly correlated with plasma BTG in the normotensive subjects, whereas this relationship was lost in the hypertensive patients. Our results suggest that the increase in plasma PDGF (PDGF-AB + PDGF-BB) in never-treated essential hypertension is mainly due to platelet activation. The increased circulating level of PDGF could play a role in the vascular structural changes associated with hypertension.

Original languageEnglish
Pages (from-to)1239-1243
Number of pages5
JournalAmerican Journal of Hypertension
Volume11
Issue number10 I
DOIs
Publication statusPublished - Oct 1998

Keywords

  • β- thromboglobulin
  • Essential hypertension
  • Platelet-derived growth factor
  • Platelets

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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