Abstract
Platelet-derived growth factor (PDGF) could play a role in both vascular hypertrophy and atherosclerotic disease associated with hypertension. To assess whether plasma PDGF level is increased in mild essential hypertension, we measured plasma PDGF concentration in 25 never-treated patients with uncomplicated mild essential hypertension and in 22 normotensive healthy subjects. To evaluate the contribution of platelets to plasma PDGF in the two groups, we also measured plasma β-thromboglobulin (BTG). Measurement of PDGF was carried out through an enzyme-linked immunoadsorbent assay, which detects two PDGF dimers, namely PDGF-BB and PDGF-AB. Both plasma PDGF and BTG were higher in the hypertensive than in the normotensive subjects. The ratio of PDGF to BTG was similar in the two groups. Plasma PDGF was weakly correlated with plasma BTG in the normotensive subjects, whereas this relationship was lost in the hypertensive patients. Our results suggest that the increase in plasma PDGF (PDGF-AB + PDGF-BB) in never-treated essential hypertension is mainly due to platelet activation. The increased circulating level of PDGF could play a role in the vascular structural changes associated with hypertension.
| Original language | English |
|---|---|
| Pages (from-to) | 1239-1243 |
| Number of pages | 5 |
| Journal | American Journal of Hypertension |
| Volume | 11 |
| Issue number | 10 I |
| DOIs | |
| Publication status | Published - Oct 1998 |
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Keywords
- β- thromboglobulin
- Essential hypertension
- Platelet-derived growth factor
- Platelets
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Increased plasma levels of platelet-derived growth factor (PDGF-BB + PDGF-AB) in patients with never-treated mild essential hypertension. / Rossi, Ermanno; Casali, Bruno; Regolisti, Giuseppe; Davoli, Simona; Perazzoli, Franco; Negro, Aurelio; Sani, Carlo; Tumiati, Bruno; Nicoli, Davide.
In: American Journal of Hypertension, Vol. 11, No. 10 I, 10.1998, p. 1239-1243.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased plasma levels of platelet-derived growth factor (PDGF-BB + PDGF-AB) in patients with never-treated mild essential hypertension
AU - Rossi, Ermanno
AU - Casali, Bruno
AU - Regolisti, Giuseppe
AU - Davoli, Simona
AU - Perazzoli, Franco
AU - Negro, Aurelio
AU - Sani, Carlo
AU - Tumiati, Bruno
AU - Nicoli, Davide
PY - 1998/10
Y1 - 1998/10
N2 - Platelet-derived growth factor (PDGF) could play a role in both vascular hypertrophy and atherosclerotic disease associated with hypertension. To assess whether plasma PDGF level is increased in mild essential hypertension, we measured plasma PDGF concentration in 25 never-treated patients with uncomplicated mild essential hypertension and in 22 normotensive healthy subjects. To evaluate the contribution of platelets to plasma PDGF in the two groups, we also measured plasma β-thromboglobulin (BTG). Measurement of PDGF was carried out through an enzyme-linked immunoadsorbent assay, which detects two PDGF dimers, namely PDGF-BB and PDGF-AB. Both plasma PDGF and BTG were higher in the hypertensive than in the normotensive subjects. The ratio of PDGF to BTG was similar in the two groups. Plasma PDGF was weakly correlated with plasma BTG in the normotensive subjects, whereas this relationship was lost in the hypertensive patients. Our results suggest that the increase in plasma PDGF (PDGF-AB + PDGF-BB) in never-treated essential hypertension is mainly due to platelet activation. The increased circulating level of PDGF could play a role in the vascular structural changes associated with hypertension.
AB - Platelet-derived growth factor (PDGF) could play a role in both vascular hypertrophy and atherosclerotic disease associated with hypertension. To assess whether plasma PDGF level is increased in mild essential hypertension, we measured plasma PDGF concentration in 25 never-treated patients with uncomplicated mild essential hypertension and in 22 normotensive healthy subjects. To evaluate the contribution of platelets to plasma PDGF in the two groups, we also measured plasma β-thromboglobulin (BTG). Measurement of PDGF was carried out through an enzyme-linked immunoadsorbent assay, which detects two PDGF dimers, namely PDGF-BB and PDGF-AB. Both plasma PDGF and BTG were higher in the hypertensive than in the normotensive subjects. The ratio of PDGF to BTG was similar in the two groups. Plasma PDGF was weakly correlated with plasma BTG in the normotensive subjects, whereas this relationship was lost in the hypertensive patients. Our results suggest that the increase in plasma PDGF (PDGF-AB + PDGF-BB) in never-treated essential hypertension is mainly due to platelet activation. The increased circulating level of PDGF could play a role in the vascular structural changes associated with hypertension.
KW - β- thromboglobulin
KW - Essential hypertension
KW - Platelet-derived growth factor
KW - Platelets
UR - http://www.scopus.com/inward/record.url?scp=0031788843&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0031788843&partnerID=8YFLogxK
U2 - 10.1016/S0895-7061(98)00124-1
DO - 10.1016/S0895-7061(98)00124-1
M3 - Article
C2 - 9799041
AN - SCOPUS:0031788843
VL - 11
SP - 1239
EP - 1243
JO - American Journal of Hypertension
JF - American Journal of Hypertension
SN - 0895-7061
IS - 10 I
ER -