Increased plasma levels of soluble CD40 ligand correlate with platelet activation markers and underline the need for standardized pre-analytical conditions

Silvia Riondino, Francesca Martini, Francesca La Farina, Antonella Spila, Fiorella Guadagni, Patrizia Ferroni

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: To investigate whether sCD40L dosage might represent a useful tool to explore in vivo platelet function. Design and methods: sCD40L and sP-selectin levels and light transmission aggregometry (LTA) were analyzed in 69 healthy donors. Immunoassays were performed on platelet-depleted citrate plasma samples. The effects of in vitro aspirin treatment on the release of sCD40L were investigated in 15 subjects following platelet stimulation. The effects of a 1-month therapeutic course of low-dose aspirin on sP-selectin and sCD40L levels were also investigated. Results: A significant correlation was observed between sCD40L and sP-selectin (p

Original languageEnglish
Pages (from-to)666-670
Number of pages5
JournalClinical Biochemistry
Volume43
Issue number7-8
DOIs
Publication statusPublished - May 2010

Keywords

  • Aspirin
  • Light transmission aggregometry
  • Platelets
  • SCD40L
  • SP-selectin

ASJC Scopus subject areas

  • Clinical Biochemistry

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