Increased plasma levels of the C-C chemokine RANTES in patients with primary HIV-1 infection

M. S. Malnati, G. Tambussi, E. Clerici, S. Polo, M. Algeri, V. Nardese, L. Furci, A. Lazzarin, P. Lusso

Research output: Contribution to journalArticle

Abstract

To investigate the role played by chemokines in the natural history immunodeficiency virus (HIV) infection, we measured the plasma levels of RANTES, MIP-1α and MIP-1β in a cohort of patients with primary HIV-1 infection (PHI) followed longitudinally. The cohort included 17 patients with well-documented history of acute HIV syndrome within two months of the first observation. The mean plasma concentration of RANTES, but not that of MIP-1α or MIP-1β, was significantly higher in patients with PHI (192.3 ng/ml) than in five HIV-seronegative controls (8.0 ng/ml) studied during the same time period. Treatment of blood with a cocktail of drugs preventing platelet activation, followed by high-speed centrifugation, reduced the levels of RANTES by approximately 2 logs both in patients and in controls, indicating that the bulk of RANTES was released by platelets, which are known to store this chemokine in their α-granules, in the immediate aftermath of blood drawing. No correlation was seen between the levels of RANTES and the number of HIV genome equivalents in plasma. These data suggest that large amounts of pre-formed RANTES are stored in platelets and, possibly, in other blood cells during the early phases of HIV infection. The possible role of this HIV-suppressive chemokine in the control of viral replication during PHI remains to be established.

Original languageEnglish
Pages (from-to)40-42
Number of pages3
JournalJournal of Biological Regulators and Homeostatic Agents
Volume11
Issue number1-2
Publication statusPublished - Jan 1997

Keywords

  • C-C chemokines
  • HIV-1
  • Plasma
  • Platelets
  • Primary infection
  • RANTES

ASJC Scopus subject areas

  • Immunology
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Physiology (medical)
  • Medicine (miscellaneous)
  • Physiology
  • Agricultural and Biological Sciences(all)

Fingerprint Dive into the research topics of 'Increased plasma levels of the C-C chemokine RANTES in patients with primary HIV-1 infection'. Together they form a unique fingerprint.

Cite this