Increased platelet sensitivity and thromboxane B2 formation in type-II hyperlipoproteinaemic patients

E. Tremoli, P. Maderna, S. Colli, G. Morazzoni, M. Sirtori, C. R. Sirtori

Research output: Contribution to journalArticle

Abstract

Platelet aggregation induced by collagen, ADP and epinephrine, was monitored in 150 type-II patients (115 type IIA and 35 type IIB) and compared with a reference group of normolipidaemic controls; in addition, malondialdehyde formation and thromboxane B2 were examined in a subsample of the type-IIA patients. Threshold aggregatory concentrations were significantly lower in the whole group of type-II patients for all three aggregating agents; no difference in terms of aggregatory response was detected between platelets from type-IA and -IIB patients. Only 56% of type-II patients, however, exceeded the 95th percentile of the threshold aggregatory concentrations in controls. The formation of malondialdehyde in platelet-rich plasma stimulated with thrombin and collagen, was significantly higher in platelets from type-IIA patients. The production of thromboxane B2 by platelets, from endogenous arachidonic acid in type-IIA patients, was significantly higher and exceeded the highest level found in controls.

Original languageEnglish
Pages (from-to)329-333
Number of pages5
JournalEuropean Journal of Clinical Investigation
Volume14
Issue number5
Publication statusPublished - 1984

ASJC Scopus subject areas

  • Medicine(all)

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