Increased preproneuropeptide Y mRNA in the rat hippocampus during the development of hippocampal kindling: Comparison with the expression of preprosomatostatin mRNA

C. Bendotti, A. Vezzani, R. Serafini, A. Servadio, R. Rivolta, R. Samanin

Research output: Contribution to journalArticlepeer-review

Abstract

The levels of preproneuropeptide Y (ppNPY) mRNA and preprosomatostatin (ppSOM) mRNA were analyzed in different brain regions during the development of hippocampal kindling in rats. ppNPY mRNA levels were markedly elevated in the dorsal hippocampus bilaterally, two days after stage 2 (preconvulsive stage) and stage 5 (full seizure expression). The contents of ppSOM mRNA were slightly, although not significantly. increased in the dorsal hippocampus at stage 2 whereas a significant increase was observed in the ipsilateral hippocampus of fully kindled rats. ppNPY and ppSOM mRNA levels were unchanged in the cortex and striatum at both stages of kindling. These results show that an increased synthesis of somatostatin and neuropeptide Y, with a greater effect for the latter, occurs during hippocampal kindling in rats. The relative role of the two peptides in the development and expression of kindling phenomenon remains to be elucidated.

Original languageEnglish
Pages (from-to)175-178
Number of pages4
JournalNeuroscience Letters
Volume132
Issue number2
DOIs
Publication statusPublished - Nov 11 1991

Keywords

  • Hippocampus
  • Kindling
  • Preproneuropeptide Y mRNA
  • Preprosomatostatin mRNA
  • Rat
  • Seizure

ASJC Scopus subject areas

  • Neuroscience(all)

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