Increased prevalence of autoimmune phenomena in myelofibrosis: Relationship with clinical and morphological characteristics, and with immunoregulatory cytokine patterns

Wilma Barcellini; Alessandra Iurlo; Tommaso Radice; Francesca Guia Imperiali; Anna Zaninoni; Bruno Fattizzo; Francesca Guidotti; Paola Bianchi; Elisa Fermo; Dario Consonni; Agostino Cortelezzi

doi:10.1016/j.leukres.2013.09.001

Increased prevalence of autoimmune phenomena in myelofibrosis: Relationship with clinical and morphological characteristics, and with immunoregulatory cytokine patterns

Wilma Barcellini, Alessandra Iurlo, Tommaso Radice, Francesca Guia Imperiali, Anna Zaninoni, Bruno Fattizzo, Francesca Guidotti, Paola Bianchi, Elisa Fermo, Dario Consonni, Agostino Cortelezzi

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Autoimmune phenomena and cytokines were investigated in 100 patients with myelofibrosis (MF) and related to marrow fibrosis and clinical risk. Anti-erythrocyte antibodies by mitogen-stimulated direct antiglobulin test (MS-DAT) were positive in 45%, anti-platelets in 15% and organ/non organ-specific in 57% of cases, without clinically overt disease, and mostly in low-risk/intermediate-risk-1 and MF-0/MF-1. TGF-β and IL-8 were increased in MS-DAT positive cases, and IFN-γ in patients with serological autoantibodies. TGF-β and IL-17 were elevated in early clinical and morphological stages, while IL-8 increased in advanced stages. These data suggest that autoimmune phenomena and cytokine disregulation are particularly relevant in early MF.

Original language	English
Pages (from-to)	1509-1515
Number of pages	7
Journal	Leukemia Research
Volume	37
Issue number	11
DOIs	https://doi.org/10.1016/j.leukres.2013.09.001
Publication status	Published - Nov 2013

Keywords

Autoimmunity
Cytokines
Myelofibrosis

ASJC Scopus subject areas

Cancer Research
Hematology
Oncology

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10.1016/j.leukres.2013.09.001

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Barcellini, W., Iurlo, A., Radice, T., Imperiali, F. G., Zaninoni, A., Fattizzo, B., Guidotti, F., Bianchi, P., Fermo, E., Consonni, D., & Cortelezzi, A. (2013). Increased prevalence of autoimmune phenomena in myelofibrosis: Relationship with clinical and morphological characteristics, and with immunoregulatory cytokine patterns. Leukemia Research, 37(11), 1509-1515. https://doi.org/10.1016/j.leukres.2013.09.001

Increased prevalence of autoimmune phenomena in myelofibrosis : Relationship with clinical and morphological characteristics, and with immunoregulatory cytokine patterns. / Barcellini, Wilma ; Iurlo, Alessandra; Radice, Tommaso; Imperiali, Francesca Guia; Zaninoni, Anna; Fattizzo, Bruno; Guidotti, Francesca; Bianchi, Paola; Fermo, Elisa ; Consonni, Dario; Cortelezzi, Agostino.

In: Leukemia Research, Vol. 37, No. 11, 11.2013, p. 1509-1515.

Research output: Contribution to journal › Article › peer-review

Barcellini, W , Iurlo, A, Radice, T, Imperiali, FG, Zaninoni, A, Fattizzo, B, Guidotti, F, Bianchi, P, Fermo, E , Consonni, D & Cortelezzi, A 2013, 'Increased prevalence of autoimmune phenomena in myelofibrosis: Relationship with clinical and morphological characteristics, and with immunoregulatory cytokine patterns', Leukemia Research, vol. 37, no. 11, pp. 1509-1515. https://doi.org/10.1016/j.leukres.2013.09.001

Barcellini, Wilma ; Iurlo, Alessandra ; Radice, Tommaso ; Imperiali, Francesca Guia ; Zaninoni, Anna ; Fattizzo, Bruno ; Guidotti, Francesca ; Bianchi, Paola ; Fermo, Elisa ; Consonni, Dario ; Cortelezzi, Agostino. / Increased prevalence of autoimmune phenomena in myelofibrosis : Relationship with clinical and morphological characteristics, and with immunoregulatory cytokine patterns. In: Leukemia Research. 2013 ; Vol. 37, No. 11. pp. 1509-1515.

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abstract = "Autoimmune phenomena and cytokines were investigated in 100 patients with myelofibrosis (MF) and related to marrow fibrosis and clinical risk. Anti-erythrocyte antibodies by mitogen-stimulated direct antiglobulin test (MS-DAT) were positive in 45%, anti-platelets in 15% and organ/non organ-specific in 57% of cases, without clinically overt disease, and mostly in low-risk/intermediate-risk-1 and MF-0/MF-1. TGF-β and IL-8 were increased in MS-DAT positive cases, and IFN-γ in patients with serological autoantibodies. TGF-β and IL-17 were elevated in early clinical and morphological stages, while IL-8 increased in advanced stages. These data suggest that autoimmune phenomena and cytokine disregulation are particularly relevant in early MF.",

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AU - Imperiali, Francesca Guia

AU - Zaninoni, Anna

AU - Fattizzo, Bruno

AU - Guidotti, Francesca

AU - Bianchi, Paola

AU - Fermo, Elisa

AU - Consonni, Dario

AU - Cortelezzi, Agostino

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AB - Autoimmune phenomena and cytokines were investigated in 100 patients with myelofibrosis (MF) and related to marrow fibrosis and clinical risk. Anti-erythrocyte antibodies by mitogen-stimulated direct antiglobulin test (MS-DAT) were positive in 45%, anti-platelets in 15% and organ/non organ-specific in 57% of cases, without clinically overt disease, and mostly in low-risk/intermediate-risk-1 and MF-0/MF-1. TGF-β and IL-8 were increased in MS-DAT positive cases, and IFN-γ in patients with serological autoantibodies. TGF-β and IL-17 were elevated in early clinical and morphological stages, while IL-8 increased in advanced stages. These data suggest that autoimmune phenomena and cytokine disregulation are particularly relevant in early MF.

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Increased prevalence of autoimmune phenomena in myelofibrosis: Relationship with clinical and morphological characteristics, and with immunoregulatory cytokine patterns

Abstract

Keywords

ASJC Scopus subject areas

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