Increased prevalence of autoimmune phenomena in myelofibrosis: Relationship with clinical and morphological characteristics, and with immunoregulatory cytokine patterns

Wilma Barcellini, Alessandra Iurlo, Tommaso Radice, Francesca Guia Imperiali, Anna Zaninoni, Bruno Fattizzo, Francesca Guidotti, Paola Bianchi, Elisa Fermo, Dario Consonni, Agostino Cortelezzi

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18 Citations (Scopus)

Abstract

Autoimmune phenomena and cytokines were investigated in 100 patients with myelofibrosis (MF) and related to marrow fibrosis and clinical risk. Anti-erythrocyte antibodies by mitogen-stimulated direct antiglobulin test (MS-DAT) were positive in 45%, anti-platelets in 15% and organ/non organ-specific in 57% of cases, without clinically overt disease, and mostly in low-risk/intermediate-risk-1 and MF-0/MF-1. TGF-β and IL-8 were increased in MS-DAT positive cases, and IFN-γ in patients with serological autoantibodies. TGF-β and IL-17 were elevated in early clinical and morphological stages, while IL-8 increased in advanced stages. These data suggest that autoimmune phenomena and cytokine disregulation are particularly relevant in early MF.

Original languageEnglish
Pages (from-to)1509-1515
Number of pages7
JournalLeukemia Research
Volume37
Issue number11
DOIs
Publication statusPublished - Nov 2013

Fingerprint

Primary Myelofibrosis
Cytokines
Coombs Test
Interleukin-8
Mitogens
Interleukin-17
Autoantibodies
Anti-Idiotypic Antibodies
Fibrosis
Blood Platelets
Erythrocytes
Bone Marrow

Keywords

  • Autoimmunity
  • Cytokines
  • Myelofibrosis

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

Cite this

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abstract = "Autoimmune phenomena and cytokines were investigated in 100 patients with myelofibrosis (MF) and related to marrow fibrosis and clinical risk. Anti-erythrocyte antibodies by mitogen-stimulated direct antiglobulin test (MS-DAT) were positive in 45{\%}, anti-platelets in 15{\%} and organ/non organ-specific in 57{\%} of cases, without clinically overt disease, and mostly in low-risk/intermediate-risk-1 and MF-0/MF-1. TGF-β and IL-8 were increased in MS-DAT positive cases, and IFN-γ in patients with serological autoantibodies. TGF-β and IL-17 were elevated in early clinical and morphological stages, while IL-8 increased in advanced stages. These data suggest that autoimmune phenomena and cytokine disregulation are particularly relevant in early MF.",
keywords = "Autoimmunity, Cytokines, Myelofibrosis",
author = "Wilma Barcellini and Alessandra Iurlo and Tommaso Radice and Imperiali, {Francesca Guia} and Anna Zaninoni and Bruno Fattizzo and Francesca Guidotti and Paola Bianchi and Elisa Fermo and Dario Consonni and Agostino Cortelezzi",
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T1 - Increased prevalence of autoimmune phenomena in myelofibrosis

T2 - Relationship with clinical and morphological characteristics, and with immunoregulatory cytokine patterns

AU - Barcellini, Wilma

AU - Iurlo, Alessandra

AU - Radice, Tommaso

AU - Imperiali, Francesca Guia

AU - Zaninoni, Anna

AU - Fattizzo, Bruno

AU - Guidotti, Francesca

AU - Bianchi, Paola

AU - Fermo, Elisa

AU - Consonni, Dario

AU - Cortelezzi, Agostino

PY - 2013/11

Y1 - 2013/11

N2 - Autoimmune phenomena and cytokines were investigated in 100 patients with myelofibrosis (MF) and related to marrow fibrosis and clinical risk. Anti-erythrocyte antibodies by mitogen-stimulated direct antiglobulin test (MS-DAT) were positive in 45%, anti-platelets in 15% and organ/non organ-specific in 57% of cases, without clinically overt disease, and mostly in low-risk/intermediate-risk-1 and MF-0/MF-1. TGF-β and IL-8 were increased in MS-DAT positive cases, and IFN-γ in patients with serological autoantibodies. TGF-β and IL-17 were elevated in early clinical and morphological stages, while IL-8 increased in advanced stages. These data suggest that autoimmune phenomena and cytokine disregulation are particularly relevant in early MF.

AB - Autoimmune phenomena and cytokines were investigated in 100 patients with myelofibrosis (MF) and related to marrow fibrosis and clinical risk. Anti-erythrocyte antibodies by mitogen-stimulated direct antiglobulin test (MS-DAT) were positive in 45%, anti-platelets in 15% and organ/non organ-specific in 57% of cases, without clinically overt disease, and mostly in low-risk/intermediate-risk-1 and MF-0/MF-1. TGF-β and IL-8 were increased in MS-DAT positive cases, and IFN-γ in patients with serological autoantibodies. TGF-β and IL-17 were elevated in early clinical and morphological stages, while IL-8 increased in advanced stages. These data suggest that autoimmune phenomena and cytokine disregulation are particularly relevant in early MF.

KW - Autoimmunity

KW - Cytokines

KW - Myelofibrosis

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