Abstract
Autoimmune phenomena and cytokines were investigated in 100 patients with myelofibrosis (MF) and related to marrow fibrosis and clinical risk. Anti-erythrocyte antibodies by mitogen-stimulated direct antiglobulin test (MS-DAT) were positive in 45%, anti-platelets in 15% and organ/non organ-specific in 57% of cases, without clinically overt disease, and mostly in low-risk/intermediate-risk-1 and MF-0/MF-1. TGF-β and IL-8 were increased in MS-DAT positive cases, and IFN-γ in patients with serological autoantibodies. TGF-β and IL-17 were elevated in early clinical and morphological stages, while IL-8 increased in advanced stages. These data suggest that autoimmune phenomena and cytokine disregulation are particularly relevant in early MF.
| Original language | English |
|---|---|
| Pages (from-to) | 1509-1515 |
| Number of pages | 7 |
| Journal | Leukemia Research |
| Volume | 37 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 2013 |
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Keywords
- Autoimmunity
- Cytokines
- Myelofibrosis
ASJC Scopus subject areas
- Cancer Research
- Hematology
- Oncology
Cite this
Increased prevalence of autoimmune phenomena in myelofibrosis : Relationship with clinical and morphological characteristics, and with immunoregulatory cytokine patterns. / Barcellini, Wilma; Iurlo, Alessandra; Radice, Tommaso; Imperiali, Francesca Guia; Zaninoni, Anna; Fattizzo, Bruno; Guidotti, Francesca; Bianchi, Paola; Fermo, Elisa; Consonni, Dario; Cortelezzi, Agostino.
In: Leukemia Research, Vol. 37, No. 11, 11.2013, p. 1509-1515.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased prevalence of autoimmune phenomena in myelofibrosis
T2 - Relationship with clinical and morphological characteristics, and with immunoregulatory cytokine patterns
AU - Barcellini, Wilma
AU - Iurlo, Alessandra
AU - Radice, Tommaso
AU - Imperiali, Francesca Guia
AU - Zaninoni, Anna
AU - Fattizzo, Bruno
AU - Guidotti, Francesca
AU - Bianchi, Paola
AU - Fermo, Elisa
AU - Consonni, Dario
AU - Cortelezzi, Agostino
PY - 2013/11
Y1 - 2013/11
N2 - Autoimmune phenomena and cytokines were investigated in 100 patients with myelofibrosis (MF) and related to marrow fibrosis and clinical risk. Anti-erythrocyte antibodies by mitogen-stimulated direct antiglobulin test (MS-DAT) were positive in 45%, anti-platelets in 15% and organ/non organ-specific in 57% of cases, without clinically overt disease, and mostly in low-risk/intermediate-risk-1 and MF-0/MF-1. TGF-β and IL-8 were increased in MS-DAT positive cases, and IFN-γ in patients with serological autoantibodies. TGF-β and IL-17 were elevated in early clinical and morphological stages, while IL-8 increased in advanced stages. These data suggest that autoimmune phenomena and cytokine disregulation are particularly relevant in early MF.
AB - Autoimmune phenomena and cytokines were investigated in 100 patients with myelofibrosis (MF) and related to marrow fibrosis and clinical risk. Anti-erythrocyte antibodies by mitogen-stimulated direct antiglobulin test (MS-DAT) were positive in 45%, anti-platelets in 15% and organ/non organ-specific in 57% of cases, without clinically overt disease, and mostly in low-risk/intermediate-risk-1 and MF-0/MF-1. TGF-β and IL-8 were increased in MS-DAT positive cases, and IFN-γ in patients with serological autoantibodies. TGF-β and IL-17 were elevated in early clinical and morphological stages, while IL-8 increased in advanced stages. These data suggest that autoimmune phenomena and cytokine disregulation are particularly relevant in early MF.
KW - Autoimmunity
KW - Cytokines
KW - Myelofibrosis
UR - http://www.scopus.com/inward/record.url?scp=84886787730&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886787730&partnerID=8YFLogxK
U2 - 10.1016/j.leukres.2013.09.001
DO - 10.1016/j.leukres.2013.09.001
M3 - Article
C2 - 24080022
AN - SCOPUS:84886787730
VL - 37
SP - 1509
EP - 1515
JO - Leukemia Research
JF - Leukemia Research
SN - 0145-2126
IS - 11
ER -