Increased prevalence of autoimmune phenomena in myelofibrosis: Relationship with clinical and morphological characteristics, and with immunoregulatory cytokine patterns

Wilma Barcellini, Alessandra Iurlo, Tommaso Radice, Francesca Guia Imperiali, Anna Zaninoni, Bruno Fattizzo, Francesca Guidotti, Paola Bianchi, Elisa Fermo, Dario Consonni, Agostino Cortelezzi

Research output: Contribution to journalArticlepeer-review

Abstract

Autoimmune phenomena and cytokines were investigated in 100 patients with myelofibrosis (MF) and related to marrow fibrosis and clinical risk. Anti-erythrocyte antibodies by mitogen-stimulated direct antiglobulin test (MS-DAT) were positive in 45%, anti-platelets in 15% and organ/non organ-specific in 57% of cases, without clinically overt disease, and mostly in low-risk/intermediate-risk-1 and MF-0/MF-1. TGF-β and IL-8 were increased in MS-DAT positive cases, and IFN-γ in patients with serological autoantibodies. TGF-β and IL-17 were elevated in early clinical and morphological stages, while IL-8 increased in advanced stages. These data suggest that autoimmune phenomena and cytokine disregulation are particularly relevant in early MF.

Original languageEnglish
Pages (from-to)1509-1515
Number of pages7
JournalLeukemia Research
Volume37
Issue number11
DOIs
Publication statusPublished - Nov 2013

Keywords

  • Autoimmunity
  • Cytokines
  • Myelofibrosis

ASJC Scopus subject areas

  • Cancer Research
  • Hematology
  • Oncology

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