Increased prevalence of colonic polyps and altered lymphocyte subset pattern in the colonic lamina propria in acromegaly

Annamaria Colao, Antonio Balzano, Diego Ferone, Nicola Panza, Giovanni Grande, Paolo Marzullo, Antonio Bove, Giovanni Iodice, Bartolomeo Merola, Gaetano Lombardi

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Objective. The balance of evidence suggests that acromegaly is a risk factor for colonic neoplasia. We have evaluated the prevalence of colonic polyps in acromegalics from Southern Italy and characterized the lymphocyte subsets in the colonic lamina propria in order to analyze differences in the colonic immunological environment. Design. All the patients and controls were submitted to pancolonoscopy. Ten per-endoscopic biopsies of the intestinal mucosa surrounding polyps were carried out to evaluate lymphocyte subsets. Patients. Fifty acromegalics and 318 sex- and age-matched controls entered this study. Colonic lamina propria lymphocyte subsets were studied in 34 patients and 34 controls. Results. Colonic polyps were resected in 23 acromegalics (46%) and 42 controls (13.2%; P <0.0001); hyperplastic polyps were found in 24% and 6.3%, adenomatous polyps in 22 and 6.9%, (P <0.01), adenocarcinoma in 2 and 1.2% while synchronous polyps occurred in 18% and 2.5% (P <0.01), respectively. The number of polyps was significantly correlated with age both in acromegalics (r = 0.422, P <0.005) and in controls (r = 0.865, P <0.001). However, polyp prevalence was greater in patients aged below 40 yrs (r.r. = 1.9) and in patients with two or more skin tags (r.r. = 1.2). A significant decrease of CD20, CD19, CD16, γ/δ, CD4+/leu8- and increase of CD3 and CD4+/leu8+ was found in the lamina propria lymphocyte subsets. Conclusions. The results of this study confirm that acromegalics are at increased risk of colonic polyps compared to the healthy population. The increased prevalence of premalignant polyps, namely the adenomatous type, suggests that acromegalics should undergo a careful screening and follow-up by pancolonoscopy. An impairment of mucosal immune surveillance seems to exist in acromegaly although a causal effect in the polyp formation cannot be ruled out.

Original languageEnglish
Pages (from-to)23-28
Number of pages6
JournalClinical Endocrinology
Volume47
Issue number1
Publication statusPublished - 1997

Fingerprint

Colonic Polyps
Acromegaly
Lymphocyte Subsets
Polyps
Mucous Membrane
Adenomatous Polyps
Intestinal Mucosa
Italy
Adenocarcinoma
Biopsy
Skin
Population
Neoplasms

ASJC Scopus subject areas

  • Endocrinology

Cite this

Increased prevalence of colonic polyps and altered lymphocyte subset pattern in the colonic lamina propria in acromegaly. / Colao, Annamaria; Balzano, Antonio; Ferone, Diego; Panza, Nicola; Grande, Giovanni; Marzullo, Paolo; Bove, Antonio; Iodice, Giovanni; Merola, Bartolomeo; Lombardi, Gaetano.

In: Clinical Endocrinology, Vol. 47, No. 1, 1997, p. 23-28.

Research output: Contribution to journalArticle

Colao, A, Balzano, A, Ferone, D, Panza, N, Grande, G, Marzullo, P, Bove, A, Iodice, G, Merola, B & Lombardi, G 1997, 'Increased prevalence of colonic polyps and altered lymphocyte subset pattern in the colonic lamina propria in acromegaly', Clinical Endocrinology, vol. 47, no. 1, pp. 23-28.
Colao, Annamaria ; Balzano, Antonio ; Ferone, Diego ; Panza, Nicola ; Grande, Giovanni ; Marzullo, Paolo ; Bove, Antonio ; Iodice, Giovanni ; Merola, Bartolomeo ; Lombardi, Gaetano. / Increased prevalence of colonic polyps and altered lymphocyte subset pattern in the colonic lamina propria in acromegaly. In: Clinical Endocrinology. 1997 ; Vol. 47, No. 1. pp. 23-28.
@article{ff4b074aad7446af914fced950eb79d7,
title = "Increased prevalence of colonic polyps and altered lymphocyte subset pattern in the colonic lamina propria in acromegaly",
abstract = "Objective. The balance of evidence suggests that acromegaly is a risk factor for colonic neoplasia. We have evaluated the prevalence of colonic polyps in acromegalics from Southern Italy and characterized the lymphocyte subsets in the colonic lamina propria in order to analyze differences in the colonic immunological environment. Design. All the patients and controls were submitted to pancolonoscopy. Ten per-endoscopic biopsies of the intestinal mucosa surrounding polyps were carried out to evaluate lymphocyte subsets. Patients. Fifty acromegalics and 318 sex- and age-matched controls entered this study. Colonic lamina propria lymphocyte subsets were studied in 34 patients and 34 controls. Results. Colonic polyps were resected in 23 acromegalics (46{\%}) and 42 controls (13.2{\%}; P <0.0001); hyperplastic polyps were found in 24{\%} and 6.3{\%}, adenomatous polyps in 22 and 6.9{\%}, (P <0.01), adenocarcinoma in 2 and 1.2{\%} while synchronous polyps occurred in 18{\%} and 2.5{\%} (P <0.01), respectively. The number of polyps was significantly correlated with age both in acromegalics (r = 0.422, P <0.005) and in controls (r = 0.865, P <0.001). However, polyp prevalence was greater in patients aged below 40 yrs (r.r. = 1.9) and in patients with two or more skin tags (r.r. = 1.2). A significant decrease of CD20, CD19, CD16, γ/δ, CD4+/leu8- and increase of CD3 and CD4+/leu8+ was found in the lamina propria lymphocyte subsets. Conclusions. The results of this study confirm that acromegalics are at increased risk of colonic polyps compared to the healthy population. The increased prevalence of premalignant polyps, namely the adenomatous type, suggests that acromegalics should undergo a careful screening and follow-up by pancolonoscopy. An impairment of mucosal immune surveillance seems to exist in acromegaly although a causal effect in the polyp formation cannot be ruled out.",
author = "Annamaria Colao and Antonio Balzano and Diego Ferone and Nicola Panza and Giovanni Grande and Paolo Marzullo and Antonio Bove and Giovanni Iodice and Bartolomeo Merola and Gaetano Lombardi",
year = "1997",
language = "English",
volume = "47",
pages = "23--28",
journal = "Clinical Endocrinology",
issn = "0300-0664",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - Increased prevalence of colonic polyps and altered lymphocyte subset pattern in the colonic lamina propria in acromegaly

AU - Colao, Annamaria

AU - Balzano, Antonio

AU - Ferone, Diego

AU - Panza, Nicola

AU - Grande, Giovanni

AU - Marzullo, Paolo

AU - Bove, Antonio

AU - Iodice, Giovanni

AU - Merola, Bartolomeo

AU - Lombardi, Gaetano

PY - 1997

Y1 - 1997

N2 - Objective. The balance of evidence suggests that acromegaly is a risk factor for colonic neoplasia. We have evaluated the prevalence of colonic polyps in acromegalics from Southern Italy and characterized the lymphocyte subsets in the colonic lamina propria in order to analyze differences in the colonic immunological environment. Design. All the patients and controls were submitted to pancolonoscopy. Ten per-endoscopic biopsies of the intestinal mucosa surrounding polyps were carried out to evaluate lymphocyte subsets. Patients. Fifty acromegalics and 318 sex- and age-matched controls entered this study. Colonic lamina propria lymphocyte subsets were studied in 34 patients and 34 controls. Results. Colonic polyps were resected in 23 acromegalics (46%) and 42 controls (13.2%; P <0.0001); hyperplastic polyps were found in 24% and 6.3%, adenomatous polyps in 22 and 6.9%, (P <0.01), adenocarcinoma in 2 and 1.2% while synchronous polyps occurred in 18% and 2.5% (P <0.01), respectively. The number of polyps was significantly correlated with age both in acromegalics (r = 0.422, P <0.005) and in controls (r = 0.865, P <0.001). However, polyp prevalence was greater in patients aged below 40 yrs (r.r. = 1.9) and in patients with two or more skin tags (r.r. = 1.2). A significant decrease of CD20, CD19, CD16, γ/δ, CD4+/leu8- and increase of CD3 and CD4+/leu8+ was found in the lamina propria lymphocyte subsets. Conclusions. The results of this study confirm that acromegalics are at increased risk of colonic polyps compared to the healthy population. The increased prevalence of premalignant polyps, namely the adenomatous type, suggests that acromegalics should undergo a careful screening and follow-up by pancolonoscopy. An impairment of mucosal immune surveillance seems to exist in acromegaly although a causal effect in the polyp formation cannot be ruled out.

AB - Objective. The balance of evidence suggests that acromegaly is a risk factor for colonic neoplasia. We have evaluated the prevalence of colonic polyps in acromegalics from Southern Italy and characterized the lymphocyte subsets in the colonic lamina propria in order to analyze differences in the colonic immunological environment. Design. All the patients and controls were submitted to pancolonoscopy. Ten per-endoscopic biopsies of the intestinal mucosa surrounding polyps were carried out to evaluate lymphocyte subsets. Patients. Fifty acromegalics and 318 sex- and age-matched controls entered this study. Colonic lamina propria lymphocyte subsets were studied in 34 patients and 34 controls. Results. Colonic polyps were resected in 23 acromegalics (46%) and 42 controls (13.2%; P <0.0001); hyperplastic polyps were found in 24% and 6.3%, adenomatous polyps in 22 and 6.9%, (P <0.01), adenocarcinoma in 2 and 1.2% while synchronous polyps occurred in 18% and 2.5% (P <0.01), respectively. The number of polyps was significantly correlated with age both in acromegalics (r = 0.422, P <0.005) and in controls (r = 0.865, P <0.001). However, polyp prevalence was greater in patients aged below 40 yrs (r.r. = 1.9) and in patients with two or more skin tags (r.r. = 1.2). A significant decrease of CD20, CD19, CD16, γ/δ, CD4+/leu8- and increase of CD3 and CD4+/leu8+ was found in the lamina propria lymphocyte subsets. Conclusions. The results of this study confirm that acromegalics are at increased risk of colonic polyps compared to the healthy population. The increased prevalence of premalignant polyps, namely the adenomatous type, suggests that acromegalics should undergo a careful screening and follow-up by pancolonoscopy. An impairment of mucosal immune surveillance seems to exist in acromegaly although a causal effect in the polyp formation cannot be ruled out.

UR - http://www.scopus.com/inward/record.url?scp=8544277281&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=8544277281&partnerID=8YFLogxK

M3 - Article

VL - 47

SP - 23

EP - 28

JO - Clinical Endocrinology

JF - Clinical Endocrinology

SN - 0300-0664

IS - 1

ER -