Increased prevalence of prolonged QT interval in males with primary or secondary hypogonadism: A pilot study

F. Pecori Giraldi, P. M. Toja, B. Filippini, J. Michailidis, M. Scacchi, M. Stramba Badiale, F. Cavagnini

Research output: Contribution to journalArticlepeer-review


Symptoms and signs of male hypogonadism span all organ systems, including the cardiovascular apparatus. The electrocardiographic QT interval reflects cardiac ventricular repolarization and, if prolonged, increases the risk of malignant arrhythmias. QT interval duration is similar in boys and girls during childhood, but shortens in males after puberty and experimental studies suggest that testosterone is a major contributor to shortening of QT interval in men. The aim of the present pilot study was to assess the duration of ventricular repolarization in adult males with primary or secondary hypogonadism. Standard ECG recordings were performed in 26 men (mean age 39.2 ± 2.17 years) with pituitary or testicular hypogonadism and repeated in 15 patients during testosterone replacement. Twenty-six age-matched control men were also analysed. Measured QT intervals were corrected for heart rate according to Bazzett's formula (QTc = QT/√RR interval). The prevalence of prolonged QTc was considerably higher in hypogonadal patients (four of 26 men) than in control men (none, p <0.05) and in the general, healthy population (

Original languageEnglish
JournalInternational Journal of Andrology
Issue number1
Publication statusPublished - Feb 2010


  • Hypogonadism
  • Klinefelter's syndrome
  • QT interval
  • Testosterone
  • Ventricular repolarization

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Reproductive Medicine
  • Urology


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