Increased prevalence of thyroid autoimmunity in patients successfully treated for Cushing's disease

Annamaria Colao, Rosario Pivonello, Antongiulio Faggiano, Mariagiovanna Filippella, Diego Ferone, Carolina Di Somma, Gaetana Cerbone, Paolo Marzullo, Gianfranco Fenzi, Gaetano Lombardi

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND. Cushing's disease is characterized by abnormalities of immune function. OBJECTIVE. To evaluate the prevalence of autoimmune thyroid diseases in patients with Cushing's disease (CD), after successful treatment and the possible association between previous nodular goitre or positive thyroid autoantibodies during the active phase of CD and the subsequent development of autoimmune thyroid diseases after cure. SUBJECTS AND METHODS. Twenty patients with CD and 40 sex- and age-matched healthy controls were considered for the study. In CD patients, thyroid ultrasonography and measurement of circulating free thyroxine (fT4), free triiodothyronine (fT3), thyroid stimulating hormone (TSH), antithyroglobulin (anti-Tg) and antithyroperoxidase (anti-TPO) antibodies were performed at diagnosis and 6 months after disease cure while in controls they were performed only at study entry. RESULTS. Serum fT3, and fT4 levels were similar in patients, either during the active phase or after cure of the disease, and controls. Conversely, in the patients, serum TSH levels were significantly lower during active disease (0.4±0.05 mU/l, P=0.001) and significantly higher after disease cure (4.7±0.1 mU/l, P

Original languageEnglish
Pages (from-to)13-19
Number of pages7
JournalClinical Endocrinology
Volume53
Issue number1
DOIs
Publication statusPublished - 2000

ASJC Scopus subject areas

  • Endocrinology

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