Increased proportion of suppressor/cytotoxic (OKT8+) cells in patients with Hodgkin's disease in long-lasting remission

F. Lauria, R. Foa, M. Gobbi, C. Camaschella, P. Lusso, D. Raspadori, S. Tura

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Abstract

The distribution of T-lymphocyte subsets in patients with Hodgkin's disease (HD) at diagnosis and in those disease-free off-therapy for over 5 years, was assessed with OKT monoclonal antibodies. In patients at diagnosis, T-cell subsets appeared substantially balanced with only a moderate reduction in the proportion and absolute number of OKT4 (helper/inducer) positive cells, suggesting that the lymphopenia, constantly associated with HD at diagnosis, is mainly due to a reduction in the helper/inducer T-cell subpopulation. In patients off-therapy, a reduced proportion, but normal absolute number, of OKT4+ cells was constantly accompanied by a significant increase in the proportion and absolute number of OKT8+ cells, compared with patients at diagnosis and normal controls (40% ± 11 versus 24% ± 7 and versus 23 ± 6, respectively). Consequently the OKT4/OKT8 ratio, normal or near normal in patients at diagnosis (1.70 versus 2.00), was significantly reduced in patients off-therapy (0.78 versus 2.00, P <0.001). These data suggest that in patients with HD at diagnosis, T-cell subpopulations are substantially normal, while a significant abnormality was observed in patients with HD off-therapy and potentially 'cured'. Further investigations will better elucidate these findings probably related to the cytotoxic radiotherapy and chemotherapy.

Original languageEnglish
Pages (from-to)1385-1388
Number of pages4
JournalCancer
Volume52
Issue number8
Publication statusPublished - 1983

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Hodgkin Disease
T-Lymphocyte Subsets
Helper-Inducer T-Lymphocytes
Cell Count
Lymphopenia
Therapeutics
Radiotherapy
Monoclonal Antibodies
T-Lymphocytes
Drug Therapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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Increased proportion of suppressor/cytotoxic (OKT8+) cells in patients with Hodgkin's disease in long-lasting remission. / Lauria, F.; Foa, R.; Gobbi, M.; Camaschella, C.; Lusso, P.; Raspadori, D.; Tura, S.

In: Cancer, Vol. 52, No. 8, 1983, p. 1385-1388.

Research output: Contribution to journalArticle

Lauria, F. ; Foa, R. ; Gobbi, M. ; Camaschella, C. ; Lusso, P. ; Raspadori, D. ; Tura, S. / Increased proportion of suppressor/cytotoxic (OKT8+) cells in patients with Hodgkin's disease in long-lasting remission. In: Cancer. 1983 ; Vol. 52, No. 8. pp. 1385-1388.
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