Increased replication of sendai virus in morphine-treated epithelial cells: Evidence for the involvement of the intracellular levels of glutathione

Iole Macchia, Anna T. Palamara, Cristina Bué, Patrizia Savini, Maria Ciriolo, Roberta Gaziano, Paolo Di Francesco

Research output: Contribution to journalArticle

Abstract

This paper shows that morphine increases Sendai virus replication in cultured epithelial cells. The effect was maximal when it was added before viral infection. Morphine also reduced the intracellular level of glutathione, namely, the oxidative and most abundant cell thiol. Altered intracellular redox status has recently been proposed as a factor influencing viral infection. Support for this view was provided by our data showing that inhibition of de novo glutathione synthesis, using L-buthionine sulfoximine, increased virus replication. These findings provide the first evidence that morphine increases the susceptibility to virus infection by altering the intracellular levels of glutathione. Copyright (C) 1998 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)185-193
Number of pages9
JournalInternational Journal of Immunopharmacology
Volume21
Issue number3
DOIs
Publication statusPublished - Apr 6 1999

Keywords

  • Epithelial cells
  • Glutathione
  • Morphine
  • Opioids
  • Oxidative stress
  • Paramixovirus
  • Viral infection

ASJC Scopus subject areas

  • Immunology
  • Pharmacology

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