TY - JOUR
T1 - Increased risk for venous thrombosis in carriers of the prothrombin G→A20210 gene variant
AU - Margaglione, Maurizio
AU - Brancaccio, Vincenzo
AU - Giuliani, Nicola
AU - D'Andrea, Giovanna
AU - Cappucci, Giuseppe
AU - Iannaccone, Luigi
AU - Vecchione, Gennaro
AU - Grandone, Elvira
AU - Di Minno, Giovanni
PY - 1998/7/15
Y1 - 1998/7/15
N2 - Background: A mutation in the prothrombin gene (G→A20210) has been associated with higher plasma prothrombin levels and an increased tendency for venous thrombosis. Objective: To determine whether the prothrombin A20210 allele is independently associated with the occurrence of venous thrombosis. Design: Case-control study. Setting: Two thrombosis centers in southern Italy. Patients. 281 consecutive patients with venous thrombosis confirmed by objective tests and 850 controls. Measurements: Medical history was collected on standardized questionnaires. The presence of prothrombin G→A20210 and factor V Leiden mutations was determined by Polymerase chain reaction. The presence of anticoagulant factors and prothrombin activity was determined by tests of function. Results: In 150 controls, increased prothrombin activity (P <0.001) was associated with the prothrombin A20210 allele. This allele was more frequent in patients than in controls (8.01% compared with 2.29%; P <0.001) and was associated with an increased risk for thrombosis (odds ratio, 3.88 [95% Cl, 2.23 to 6.74]). The increase prevalence of this allele was independent of the presence of the factor V Leiden mutation. After adjustment for sex, age, arterial thrombosis, and factor V Leiden mutation, the risk was still significantly elevated (odds ratio, 3.13 [Cl, 1.89 to 5.21]). Moreover, the overall prevalence of inherited coagulation abnormalities was significantly higher in patients with thrombosis of the lower extremities than in patients with thrombosis of the upper extremities (odds ratio, 3.77 [Cl, 1.10 to 12.93]). Fourteen patients carried both the prothrombin G→A20210 and factor V Leiden mutations. Conclusions: The prothrombin A20210 allele is independently associated with the occurrence of venous thrombosis, particularly in patients with a history of thrombosis of the lower extremities.
AB - Background: A mutation in the prothrombin gene (G→A20210) has been associated with higher plasma prothrombin levels and an increased tendency for venous thrombosis. Objective: To determine whether the prothrombin A20210 allele is independently associated with the occurrence of venous thrombosis. Design: Case-control study. Setting: Two thrombosis centers in southern Italy. Patients. 281 consecutive patients with venous thrombosis confirmed by objective tests and 850 controls. Measurements: Medical history was collected on standardized questionnaires. The presence of prothrombin G→A20210 and factor V Leiden mutations was determined by Polymerase chain reaction. The presence of anticoagulant factors and prothrombin activity was determined by tests of function. Results: In 150 controls, increased prothrombin activity (P <0.001) was associated with the prothrombin A20210 allele. This allele was more frequent in patients than in controls (8.01% compared with 2.29%; P <0.001) and was associated with an increased risk for thrombosis (odds ratio, 3.88 [95% Cl, 2.23 to 6.74]). The increase prevalence of this allele was independent of the presence of the factor V Leiden mutation. After adjustment for sex, age, arterial thrombosis, and factor V Leiden mutation, the risk was still significantly elevated (odds ratio, 3.13 [Cl, 1.89 to 5.21]). Moreover, the overall prevalence of inherited coagulation abnormalities was significantly higher in patients with thrombosis of the lower extremities than in patients with thrombosis of the upper extremities (odds ratio, 3.77 [Cl, 1.10 to 12.93]). Fourteen patients carried both the prothrombin G→A20210 and factor V Leiden mutations. Conclusions: The prothrombin A20210 allele is independently associated with the occurrence of venous thrombosis, particularly in patients with a history of thrombosis of the lower extremities.
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M3 - Article
C2 - 9669991
AN - SCOPUS:0031847816
VL - 129
SP - 89
EP - 93
JO - Annals of Internal Medicine
JF - Annals of Internal Medicine
SN - 0003-4819
IS - 2
ER -