Abstract
Recent studies documented an increased risk of neoplasm in patients with myotonic dystrophies (DM). Yet, none of these studies evaluated the contribution of common cancer risk factors in such observation. In this study, we included a cohort of patients (n = 255) with an established molecular diagnosis of DM type 1 (DM1), and who receives their treatment in one of the four centers with recognized expertise in neuromuscular disorders in Rome. We estimated the prevalence of benign and malignant tumors, and assessed if lifestyle factors and/or specific disease features would be associated to their occurrence. Overall, 59 benign tumors in 54 patients and 19 malignant tumors in 17 patients were diagnosed. The most common malignant neoplasms were cancers of the skin (31.6 %), thyroid (21.0 %), ovary (10.5 %), and breast (10.5 %). Uterine fibroid was the most common benign tumor (37.6 %) in women, while pilomatricoma was the most common in men (28.6 %). Age at enrollment (OR = 1.02, 95 % CI 1.00–1.05), and female gender (OR = 5.71, 95 % CI 2.90–11.22) were associated with tumor development in DM1 patients, while thyroid disorders was associated with malignant tumors only in women (OR = 5.12, 95 % CI 1.35–19.37). There was no association between tumor development and evaluated lifestyle factors. In conclusion, the lack of association between common cancer risk factors and tumor development in DM1 support a pathogenic link between tumors and DM1 itself, emphasizing the need for a systematic surveillance. Our observation of an association between thyroid diseases in women and cancer development needs confirmation.
| Original language | English |
|---|---|
| Pages (from-to) | 492-498 |
| Number of pages | 7 |
| Journal | Journal of Neurology |
| Volume | 263 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 1 2016 |
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Keywords
- Cancer
- Myotonic dystrophy type 1
- Risk factors
- Thyroid disease
- Tumor
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
Increased risk of tumor in DM1 is not related to exposure to common lifestyle risk factors. / Bianchi, Maria Laura Ester; Leoncini, E.; Masciullo, Marcella; Modoni, A.; Gadalla, Shahinaz M.; Massa, Roberto; Rastelli, Emanuele; Terracciano, Chiara; Antonini, Giovanni; Bucci, Elisabetta; Petrucci, Antonio; Costanzi, Sandro; Santoro, Massimo; Boccia, Stefania; Silvestri, Gabriella.
In: Journal of Neurology, Vol. 263, No. 3, 01.03.2016, p. 492-498.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Increased risk of tumor in DM1 is not related to exposure to common lifestyle risk factors
AU - Bianchi, Maria Laura Ester
AU - Leoncini, E.
AU - Masciullo, Marcella
AU - Modoni, A.
AU - Gadalla, Shahinaz M.
AU - Massa, Roberto
AU - Rastelli, Emanuele
AU - Terracciano, Chiara
AU - Antonini, Giovanni
AU - Bucci, Elisabetta
AU - Petrucci, Antonio
AU - Costanzi, Sandro
AU - Santoro, Massimo
AU - Boccia, Stefania
AU - Silvestri, Gabriella
PY - 2016/3/1
Y1 - 2016/3/1
N2 - Recent studies documented an increased risk of neoplasm in patients with myotonic dystrophies (DM). Yet, none of these studies evaluated the contribution of common cancer risk factors in such observation. In this study, we included a cohort of patients (n = 255) with an established molecular diagnosis of DM type 1 (DM1), and who receives their treatment in one of the four centers with recognized expertise in neuromuscular disorders in Rome. We estimated the prevalence of benign and malignant tumors, and assessed if lifestyle factors and/or specific disease features would be associated to their occurrence. Overall, 59 benign tumors in 54 patients and 19 malignant tumors in 17 patients were diagnosed. The most common malignant neoplasms were cancers of the skin (31.6 %), thyroid (21.0 %), ovary (10.5 %), and breast (10.5 %). Uterine fibroid was the most common benign tumor (37.6 %) in women, while pilomatricoma was the most common in men (28.6 %). Age at enrollment (OR = 1.02, 95 % CI 1.00–1.05), and female gender (OR = 5.71, 95 % CI 2.90–11.22) were associated with tumor development in DM1 patients, while thyroid disorders was associated with malignant tumors only in women (OR = 5.12, 95 % CI 1.35–19.37). There was no association between tumor development and evaluated lifestyle factors. In conclusion, the lack of association between common cancer risk factors and tumor development in DM1 support a pathogenic link between tumors and DM1 itself, emphasizing the need for a systematic surveillance. Our observation of an association between thyroid diseases in women and cancer development needs confirmation.
AB - Recent studies documented an increased risk of neoplasm in patients with myotonic dystrophies (DM). Yet, none of these studies evaluated the contribution of common cancer risk factors in such observation. In this study, we included a cohort of patients (n = 255) with an established molecular diagnosis of DM type 1 (DM1), and who receives their treatment in one of the four centers with recognized expertise in neuromuscular disorders in Rome. We estimated the prevalence of benign and malignant tumors, and assessed if lifestyle factors and/or specific disease features would be associated to their occurrence. Overall, 59 benign tumors in 54 patients and 19 malignant tumors in 17 patients were diagnosed. The most common malignant neoplasms were cancers of the skin (31.6 %), thyroid (21.0 %), ovary (10.5 %), and breast (10.5 %). Uterine fibroid was the most common benign tumor (37.6 %) in women, while pilomatricoma was the most common in men (28.6 %). Age at enrollment (OR = 1.02, 95 % CI 1.00–1.05), and female gender (OR = 5.71, 95 % CI 2.90–11.22) were associated with tumor development in DM1 patients, while thyroid disorders was associated with malignant tumors only in women (OR = 5.12, 95 % CI 1.35–19.37). There was no association between tumor development and evaluated lifestyle factors. In conclusion, the lack of association between common cancer risk factors and tumor development in DM1 support a pathogenic link between tumors and DM1 itself, emphasizing the need for a systematic surveillance. Our observation of an association between thyroid diseases in women and cancer development needs confirmation.
KW - Cancer
KW - Myotonic dystrophy type 1
KW - Risk factors
KW - Thyroid disease
KW - Tumor
UR - http://www.scopus.com/inward/record.url?scp=84960419575&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84960419575&partnerID=8YFLogxK
U2 - 10.1007/s00415-015-8006-y
DO - 10.1007/s00415-015-8006-y
M3 - Article
VL - 263
SP - 492
EP - 498
JO - Journal of Neurology
JF - Journal of Neurology
SN - 0340-5354
IS - 3
ER -