Increased risk of tumor in DM1 is not related to exposure to common lifestyle risk factors

Maria Laura Ester Bianchi, Emanuele Leoncini, Marcella Masciullo, Anna Modoni, Shahinaz M. Gadalla, Roberto Massa, Emanuele Rastelli, Chiara Terracciano, Giovanni Antonini, Elisabetta Bucci, Antonio Petrucci, Sandro Costanzi, Massimo Santoro, Stefania Boccia, Gabriella Silvestri

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Recent studies documented an increased risk of neoplasm in patients with myotonic dystrophies (DM). Yet, none of these studies evaluated the contribution of common cancer risk factors in such observation. In this study, we included a cohort of patients (n = 255) with an established molecular diagnosis of DM type 1 (DM1), and who receives their treatment in one of the four centers with recognized expertise in neuromuscular disorders in Rome. We estimated the prevalence of benign and malignant tumors, and assessed if lifestyle factors and/or specific disease features would be associated to their occurrence. Overall, 59 benign tumors in 54 patients and 19 malignant tumors in 17 patients were diagnosed. The most common malignant neoplasms were cancers of the skin (31.6 %), thyroid (21.0 %), ovary (10.5 %), and breast (10.5 %). Uterine fibroid was the most common benign tumor (37.6 %) in women, while pilomatricoma was the most common in men (28.6 %). Age at enrollment (OR = 1.02, 95 % CI 1.00–1.05), and female gender (OR = 5.71, 95 % CI 2.90–11.22) were associated with tumor development in DM1 patients, while thyroid disorders was associated with malignant tumors only in women (OR = 5.12, 95 % CI 1.35–19.37). There was no association between tumor development and evaluated lifestyle factors. In conclusion, the lack of association between common cancer risk factors and tumor development in DM1 support a pathogenic link between tumors and DM1 itself, emphasizing the need for a systematic surveillance. Our observation of an association between thyroid diseases in women and cancer development needs confirmation.

Original languageEnglish
Pages (from-to)492-498
Number of pages7
JournalJournal of Neurology
Volume263
Issue number3
DOIs
Publication statusPublished - Mar 1 2016

Fingerprint

Life Style
Neoplasms
Thyroid Gland
Pilomatrixoma
Observation
Myotonic Dystrophy
Thyroid Diseases
Leiomyoma
Skin Neoplasms
Ovary
Breast

Keywords

  • Cancer
  • Myotonic dystrophy type 1
  • Risk factors
  • Thyroid disease
  • Tumor

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

Cite this

Bianchi, M. L. E., Leoncini, E., Masciullo, M., Modoni, A., Gadalla, S. M., Massa, R., ... Silvestri, G. (2016). Increased risk of tumor in DM1 is not related to exposure to common lifestyle risk factors. Journal of Neurology, 263(3), 492-498. https://doi.org/10.1007/s00415-015-8006-y

Increased risk of tumor in DM1 is not related to exposure to common lifestyle risk factors. / Bianchi, Maria Laura Ester; Leoncini, Emanuele; Masciullo, Marcella; Modoni, Anna; Gadalla, Shahinaz M.; Massa, Roberto; Rastelli, Emanuele; Terracciano, Chiara; Antonini, Giovanni; Bucci, Elisabetta; Petrucci, Antonio; Costanzi, Sandro; Santoro, Massimo; Boccia, Stefania; Silvestri, Gabriella.

In: Journal of Neurology, Vol. 263, No. 3, 01.03.2016, p. 492-498.

Research output: Contribution to journalArticle

Bianchi, MLE, Leoncini, E, Masciullo, M, Modoni, A, Gadalla, SM, Massa, R, Rastelli, E, Terracciano, C, Antonini, G, Bucci, E, Petrucci, A, Costanzi, S, Santoro, M, Boccia, S & Silvestri, G 2016, 'Increased risk of tumor in DM1 is not related to exposure to common lifestyle risk factors', Journal of Neurology, vol. 263, no. 3, pp. 492-498. https://doi.org/10.1007/s00415-015-8006-y
Bianchi, Maria Laura Ester ; Leoncini, Emanuele ; Masciullo, Marcella ; Modoni, Anna ; Gadalla, Shahinaz M. ; Massa, Roberto ; Rastelli, Emanuele ; Terracciano, Chiara ; Antonini, Giovanni ; Bucci, Elisabetta ; Petrucci, Antonio ; Costanzi, Sandro ; Santoro, Massimo ; Boccia, Stefania ; Silvestri, Gabriella. / Increased risk of tumor in DM1 is not related to exposure to common lifestyle risk factors. In: Journal of Neurology. 2016 ; Vol. 263, No. 3. pp. 492-498.
@article{9fc4490e213e4011995b159501f9c46a,
title = "Increased risk of tumor in DM1 is not related to exposure to common lifestyle risk factors",
abstract = "Recent studies documented an increased risk of neoplasm in patients with myotonic dystrophies (DM). Yet, none of these studies evaluated the contribution of common cancer risk factors in such observation. In this study, we included a cohort of patients (n = 255) with an established molecular diagnosis of DM type 1 (DM1), and who receives their treatment in one of the four centers with recognized expertise in neuromuscular disorders in Rome. We estimated the prevalence of benign and malignant tumors, and assessed if lifestyle factors and/or specific disease features would be associated to their occurrence. Overall, 59 benign tumors in 54 patients and 19 malignant tumors in 17 patients were diagnosed. The most common malignant neoplasms were cancers of the skin (31.6 {\%}), thyroid (21.0 {\%}), ovary (10.5 {\%}), and breast (10.5 {\%}). Uterine fibroid was the most common benign tumor (37.6 {\%}) in women, while pilomatricoma was the most common in men (28.6 {\%}). Age at enrollment (OR = 1.02, 95 {\%} CI 1.00–1.05), and female gender (OR = 5.71, 95 {\%} CI 2.90–11.22) were associated with tumor development in DM1 patients, while thyroid disorders was associated with malignant tumors only in women (OR = 5.12, 95 {\%} CI 1.35–19.37). There was no association between tumor development and evaluated lifestyle factors. In conclusion, the lack of association between common cancer risk factors and tumor development in DM1 support a pathogenic link between tumors and DM1 itself, emphasizing the need for a systematic surveillance. Our observation of an association between thyroid diseases in women and cancer development needs confirmation.",
keywords = "Cancer, Myotonic dystrophy type 1, Risk factors, Thyroid disease, Tumor",
author = "Bianchi, {Maria Laura Ester} and Emanuele Leoncini and Marcella Masciullo and Anna Modoni and Gadalla, {Shahinaz M.} and Roberto Massa and Emanuele Rastelli and Chiara Terracciano and Giovanni Antonini and Elisabetta Bucci and Antonio Petrucci and Sandro Costanzi and Massimo Santoro and Stefania Boccia and Gabriella Silvestri",
year = "2016",
month = "3",
day = "1",
doi = "10.1007/s00415-015-8006-y",
language = "English",
volume = "263",
pages = "492--498",
journal = "Journal of Neurology",
issn = "0340-5354",
publisher = "Dr. Dietrich Steinkopff Verlag GmbH and Co. KG",
number = "3",

}

TY - JOUR

T1 - Increased risk of tumor in DM1 is not related to exposure to common lifestyle risk factors

AU - Bianchi, Maria Laura Ester

AU - Leoncini, Emanuele

AU - Masciullo, Marcella

AU - Modoni, Anna

AU - Gadalla, Shahinaz M.

AU - Massa, Roberto

AU - Rastelli, Emanuele

AU - Terracciano, Chiara

AU - Antonini, Giovanni

AU - Bucci, Elisabetta

AU - Petrucci, Antonio

AU - Costanzi, Sandro

AU - Santoro, Massimo

AU - Boccia, Stefania

AU - Silvestri, Gabriella

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Recent studies documented an increased risk of neoplasm in patients with myotonic dystrophies (DM). Yet, none of these studies evaluated the contribution of common cancer risk factors in such observation. In this study, we included a cohort of patients (n = 255) with an established molecular diagnosis of DM type 1 (DM1), and who receives their treatment in one of the four centers with recognized expertise in neuromuscular disorders in Rome. We estimated the prevalence of benign and malignant tumors, and assessed if lifestyle factors and/or specific disease features would be associated to their occurrence. Overall, 59 benign tumors in 54 patients and 19 malignant tumors in 17 patients were diagnosed. The most common malignant neoplasms were cancers of the skin (31.6 %), thyroid (21.0 %), ovary (10.5 %), and breast (10.5 %). Uterine fibroid was the most common benign tumor (37.6 %) in women, while pilomatricoma was the most common in men (28.6 %). Age at enrollment (OR = 1.02, 95 % CI 1.00–1.05), and female gender (OR = 5.71, 95 % CI 2.90–11.22) were associated with tumor development in DM1 patients, while thyroid disorders was associated with malignant tumors only in women (OR = 5.12, 95 % CI 1.35–19.37). There was no association between tumor development and evaluated lifestyle factors. In conclusion, the lack of association between common cancer risk factors and tumor development in DM1 support a pathogenic link between tumors and DM1 itself, emphasizing the need for a systematic surveillance. Our observation of an association between thyroid diseases in women and cancer development needs confirmation.

AB - Recent studies documented an increased risk of neoplasm in patients with myotonic dystrophies (DM). Yet, none of these studies evaluated the contribution of common cancer risk factors in such observation. In this study, we included a cohort of patients (n = 255) with an established molecular diagnosis of DM type 1 (DM1), and who receives their treatment in one of the four centers with recognized expertise in neuromuscular disorders in Rome. We estimated the prevalence of benign and malignant tumors, and assessed if lifestyle factors and/or specific disease features would be associated to their occurrence. Overall, 59 benign tumors in 54 patients and 19 malignant tumors in 17 patients were diagnosed. The most common malignant neoplasms were cancers of the skin (31.6 %), thyroid (21.0 %), ovary (10.5 %), and breast (10.5 %). Uterine fibroid was the most common benign tumor (37.6 %) in women, while pilomatricoma was the most common in men (28.6 %). Age at enrollment (OR = 1.02, 95 % CI 1.00–1.05), and female gender (OR = 5.71, 95 % CI 2.90–11.22) were associated with tumor development in DM1 patients, while thyroid disorders was associated with malignant tumors only in women (OR = 5.12, 95 % CI 1.35–19.37). There was no association between tumor development and evaluated lifestyle factors. In conclusion, the lack of association between common cancer risk factors and tumor development in DM1 support a pathogenic link between tumors and DM1 itself, emphasizing the need for a systematic surveillance. Our observation of an association between thyroid diseases in women and cancer development needs confirmation.

KW - Cancer

KW - Myotonic dystrophy type 1

KW - Risk factors

KW - Thyroid disease

KW - Tumor

UR - http://www.scopus.com/inward/record.url?scp=84960419575&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84960419575&partnerID=8YFLogxK

U2 - 10.1007/s00415-015-8006-y

DO - 10.1007/s00415-015-8006-y

M3 - Article

VL - 263

SP - 492

EP - 498

JO - Journal of Neurology

JF - Journal of Neurology

SN - 0340-5354

IS - 3

ER -